A5103216338- Gallbladder and Bile Duct Disorders
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Trigeminal Neuralgia and Treatments
- Pancreatitis Pathology and Treatment
- Estrogen and related hormone effects
- Antimicrobial Peptides and Activities
- Pain Mechanisms and Treatments
- Facial Nerve Paralysis Treatment and Research
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Elbow and Forearm Trauma Treatment
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Shoulder Injury and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Silk-based biomaterials and applications
- Dermatologic Treatments and Research
- Pediatric Hepatobiliary Diseases and Treatments
- Inflammatory mediators and NSAID effects
- Orthopedic Surgery and Rehabilitation
- Redox biology and oxidative stress
- Developmental Biology and Gene Regulation
Tianjin Hospital
2017-2025
Suzhou Research Institute
2024
Suqian University
2024
Jiangsu University
2020-2023
Affiliated Hospital of Jiangsu University
2020-2023
Tongde Hospital of Zhejiang Province
2021-2023
China Medical University
2016-2021
Chengdu Military General Hospital
2010-2021
Zhejiang Academy of Forestry
2018
Huazhong University of Science and Technology
2014-2017
Abstract Notch signaling, a critical pathway for tissue development, also contributes to tumorigenesis in many cancers, but its pathological function liver cancer is not well defined. In our study, Notch1 expression and clinicopathological parameters were evaluated 82 human hepatocellular carcinoma (HCC) patients. Plasmid‐based siNotch1 shRNA was transiently or stably transfected into metastatic HCC cells subsequently the effects on orthotopic tumor metastasis mouse model as downstream...
Abstract: Fatal fungal infections in central nervous system (CNS) can occur through hematogenous spread or direct extension. At present, hydrophobic amphotericin B (AMB) is the most effective antifungal drug clinical trials. However, AMB and therefore penetrates poorly into CNS, therapeutic levels of are hard to achieve. The transferrin receptor (TfR/CD71) located at blood–brain barrier mediates transcytosis. In order enhance receptor-mediated delivery CNS with level, an anti-TfR antibody...
Abstract Background This study aimed to estimate the influence of continuous and cluster nursing on carpal tunnel syndrome (CTS) release surgery. Methods Ninety-six patients with CTS were treated in our hospital from November 2019 December 2021. These randomly divided into two groups 48 patients. Both underwent open The control group received routine care, while a combination interventions. Boston question, Visual Analogue Scale (VAS), Numerical Rating (NRS), Pittsburgh Sleep Quality Index...
Radiofrequency thermocoagulation (RFT) is an effective treatment for trigeminal neuralgia, but consensus regarding optimal temperature lacking. While temperatures ranging from 60°C to 95°C have been reported, RFT at too high a often followed by serious complications, and comparative evaluations of different in single study are rare. This current prospective cohort was compare immediate long-term outcomes varying patients with bilateral idiopathic neuralgia (ITN) maxillary division nerve...
Activating HIV-1 proviruses in latent reservoirs combined with inhibiting viral spread might be an effective anti-HIV therapeutic strategy. Active specific delivery of drugs into cells harboring HIV, without the use vectors, is a critical challenge to this objective. In study, nanoparticles poly(lactic-co-glycolic acid)-polyethylene glycol diblock copolymers conjugated anti-CD45RO antibody and loaded histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and/or protease...
MicroRNAs (miRNAs) are a class of small noncoding RNA that, through mediating posttranscriptional gene regulation, play critical role in nearly all biological processes. Over the last decade it has become apparent that plant miRNAs may serve as novel functional component food with therapeutic effects including anti-influenza and antitumor. Rapeseed bee pollen good properties enhancing immune function well preventing treating disease. In this study, we identified exogenous from rapeseed mice...
Radiofrequency thermocoagulation (RFT) is widely used to treat trigeminal neuralgia (TN); however, the optimal temperature at which RFT most efficacious remains under much debate. Thus, aim of present study was determine lowest morbidity could be minimized and patient outcomes maximized. A multivariate analysis 1354 patients who underwent computed tomography (CT)-guided for V2/V3 idiopathic (ITN) during from June 2006 May 2015. carried out 62, 65, 68°C, while keeping all other RF parameters...
Lumbar disc herniation (LDH) is a common disease in clinical practice. The symptoms recur and are aggravated by time; severe pain long-term movement disorder cause physiological psychological problems that affect the quality of life patients. Therefore, relieving promoting functional recovery primary goals have gained increased attention.To assess efficacy CT-guided transforaminal epidural steroid injection (TFESI) combined with pulsed radio frequency (PRF) on spinal nerve root for treatment...
Patients may develop serious eye complications after continuous radiofrequency thermocoagulation (CRF) for V1 (ophthalmic division) trigeminal neuralgia (TN) at a higher temperature. Therefore, the temperature of clinical CRF TN has long been disputed, but there have few reports found about how to achieve satisfactory pain relief, reduce incidence rates complications, and shorten recovery time TN. To observe whether pulsed (PRF) can lead increased rate in reduced or shortened is used treat...
Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases. Can exogenous miRNAs cross blood-prostate barrier entry prostate then participate disease treatment?Using HiSeq sequencing RT-qPCR technology, we detected enriched prostates rats among normal group, BPH model group rape bee pollen group. To forecast functions these miRNAs, psRobot software TargetFinder were used to predict their...
Background: Postherpetic neuralgia (PHN) is one of the most common and serious complications herpes zoster. PHN first branch trigeminal nerve painful difficult to treat, as no definitive effective treatment available. The aim this retrospective study was observe efficacy safety with high-voltage pulsed radiofrequency (PRF) supraorbital nerve. Methods: Fifty-two patients diagnosed at Department Pain Management, Shengjing Hospital, China Medical University, between April 2017 October 2020 were...
Objective To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI) rats, and to analyze influence HBO on expression neuronal nitric oxide synthase inducible levels inflammatory factors. Methods Rats were assigned into three groups randomly: sham, CCI, groups. The CCI rat model was established, at 2.5 ATA (60 min) given one day after surgery, lasting for five consecutive days. pain behaviors rats observed predetermined time points,...
The efficient delivery of therapeutic drugs into interested cells is a critical challenge to broad application nonviral vector systems. In this research, emtansine (DM1)-loaded star-shaped folate-core polylactide-d-α-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS-DM1) copolymer which demonstrated superior anticancer activity in vitro/vivo comparison with linear FA-PLA-TPGS nanoparticles was applied be DM1 for FR(+) breast cancer therapy. DM1- or coumarin 6-loaded were fabricated,...
ObjectiveTo investigate the impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions μ-opioid receptor in spinal dorsal horn root ganglia rats with cancer-induced bone pain. MethodsThe were randomly grouped then injected 10 μl phosphate buffer saline or Walker256 tumor cells into upper segment left tibia. Thirteen days after injection, intrathecal catheterization was performed, followed by injection saline, factor, nerve naloxone twice a day. The pain...
Objective Cancer-induced bone pain is a common clinical problem in breast cancer patients with metastasis. However, the mechanisms driving cancer-induced are poorly known. Recent studies show that novel protease, asparaginyl endopeptidase (AEP) plays crucial roles metastasis and progression. We aim to determine functions targeted suppress of AEP mouse model pain. Methods Breast cells knocked-down or overexpression were constructed implanted into intramedullary space femur induce pain-like...
Abstract Bone biomineralization is well‐regulated processes mediated by extracellular matrix proteins. The materials that can direct nucleation of hydroxylapatite (HAp) crystals and assembly well‐structured material‐minerals complex are the key to mimicking natural mineralization. This study used sericin from Antheraea pernyi ( A.pernyi ), non‐mulberry silkworm cocoon as template mediate HAp crystals. Here we find out AS (Antheraea sericin) nucleate formation in simulated body fluid verified...
Abstract Cytochromes P450 (CYPs) are important for bone homeostasis, but only limited information is available on their expression in human cells. We analyzed the levels of eight CYPs osteoblasts cultured pieces, differentiated from periosteum mesenchymal stem cells, primary and osteoblast cell line MG63, respectively. Our results confirm previous reports about presence CYP11A1, CYP17A1, CYP24A1 CYP27B1, while demonstrating CYP2E1, CYP26A1, CYP39A1 CYP51A1 first time. However, patterns four...