A5055786713- Advanced Photocatalysis Techniques
- Crystallization and Solubility Studies
- Covalent Organic Framework Applications
- X-ray Diffraction in Crystallography
- Phosphodiesterase function and regulation
- Synthesis and Biological Evaluation
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Innovative Teaching Methods
- Porphyrin Metabolism and Disorders
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Metal-Catalyzed Oxygenation Mechanisms
- Peptidase Inhibition and Analysis
- Free Radicals and Antioxidants
- Protein Structure and Dynamics
- Microbial metabolism and enzyme function
- Porphyrin and Phthalocyanine Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Thermodynamics and Molecular Structure
- Nicotinic Acetylcholine Receptors Study
- Galectins and Cancer Biology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Thermal and Kinetic Analysis
- Educational Assessment and Pedagogy
Sichuan Normal University
2023-2025
Tongde Hospital of Zhejiang Province
2023-2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Minzu University of China
2022-2024
Jilin University
2022
Jilin Province Science and Technology Department
2022
South Central Minzu University
2011-2021
Shenyang Agricultural University
2020
Southern Medical University
2018
A hydrogen-bonded dimeric supramolecualr capsule was designed, synthesized and thoroughly characterized. Structural analyses using X-ray diffraction DOSY NMR spectroscopy revealed the flexible could exist both in solid...
Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exerts antifibrotic effects on various types of organ fibrosis. However, whether GLP-1R modulates the development and progression pulmonary remains unclear. In this study, we investigated effect using in vitro vivo models A silica-induced mouse model was established to evaluate protective...
Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide, with high incidence and low survival rates. Nicotinic acetylcholine receptors play an important role in progression LUAD. In this study, a screening 17 nicotinic receptor allosteric agents revealed that spinosad effectively suppressed proliferation LUAD cells. The experiments demonstrated induced cell cycle arrest G1 phase stimulated apoptosis, thereby impeding growth enhancing responsiveness to gefitinib vitro vivo....
Alda‑1, an aldehyde dehydrogenase 2 (ALDH2) agonist, has been demonstrated to reduce injury caused by acute myocardial infarction (MI) and ischemia/reperfusion. The present study aimed investigate whether oral administration of Alda‑1 improved long‑term survival rats with chronic heart failure (CHF) post‑MI. MI model treated daily exhibited increase in 20‑week rate compared untreated rats. treatment decreased the weight/body weight ratio, collagen volume, left ventricular (LV) internal...
As important drug targets for a variety of human diseases, cyclic nucleotide phosphodiesterases (PDEs) are superfamily enzymes sharing similar catalytic site. We have performed pseudobond first-principles quantum mechanical/molecular mechanical-free energy perturbation (QM/MM-FE) and QM/MM-Poisson-Boltzmann surface area (PBSA) calculations to uncover the detailed reaction mechanism PDE4-catalyzed hydrolysis adenosine 3',5'-cyclic monophosphate (cAMP). This is first report on QM/MM...
First-principles quantum mechanical/molecular mechanical free energy calculations have been performed to examine the catalytic mechanism for cocaine esterase (CocE)-catalyzed hydrolysis of (+)-cocaine in comparison with CocE-catalyzed (−)-cocaine. It has shown that acylation consists nucleophilic attack hydroxyl group Ser117 on carbonyl carbon benzoyl ester and dissociation ester. The first reaction step deacylation (+)-cocaine, which is identical (−)-cocaine, rate-determining, indicating...
Halide anion‐doped bismuth terephthalate hybrids were synthesized using a facile solvothermal method. Four series of doped with halide anions X − (F , Cl Br and I ) produced by varying the molar ratios ( n relative to Bi(NO 3 = 0.25, 0.5, 0.75 1) in dimethylformamide solution. The results indicated that 0.25 equiv. different hybrids, especially BiBDC‐Cl(0.25) BiBDC‐Br(0.25), exhibited excellent photocatalytic activity under visible light UV irradiation. They also adsorption performance for...
Negatively charged (WO<sub>4</sub>)<sup>2−</sup> anions doped into 2D layered metal organic frameworks bismuth terephthalate provides a valuable strategy for excellent photoreduction of Cr(<sc>vi</sc>).
The combined molecular dynamics (MD) and potential of mean force (PMF) simulations have been performed to determine the free energy profiles for binding process (−)-cocaine interacting with wild-type cocaine esterase (CocE) its mutants (T172R/G173Q L119A/L169K/G173Q). According MD simulations, general protein–(−)-cocaine mode is not affected by mutations; e.g.. benzoyl group always bound in a subsite composed aromatic residues W151, W166, F261, F408 hydrophobic residue L407, while carbonyl...
Abstract Objectives Lung adenocarcinoma (LUAD) exhibits a higher fatality rate among all cancer types worldwide, yet the precise mechanisms underlying its initiation and progression remain unknown. Mounting evidence suggests that long non-coding RNAs (lncRNAs) exert significant regulatory roles in development progression. Nevertheless, involvement of lncRNA CYP4A22-AS1 LUAD remains incompletely comprehended. Methods Bioinformatics analyses evaluated expression level lung paracancer. The cell...
Doping multiple halide anions into bismuth terephthalate can effectively improve photocatalytic activities. The F<sup>–</sup>, Cl<sup>–</sup>, Br<sup>–</sup> codoped hybrids exhibit excellent activities on RhB and salicylic acid.
Effects of dietary supplemental stachyose on caecal skatole concentration, hepatic cytochrome P450 (CYP450, CYP) mRNA expressions and enzymatic activities in broilers were evaluated. Arbor Acre commercial mixed male female chicks assigned randomly into six treatments. The positive control (PC) diet was based maize-soyabean meal, the negative (NC) maize-non-soyabean meal. NC then supplemented with 4, 5, 6 7 g/kg to create experimental diets, named S-4, S-5, S-6 S-7, respectively. Each fed...
Organochlorine pesticides (OCPs) were quantified in a sediment core from Songhua Lake, large artificial lake Northeast China, to investigate their historical deposition behaviors and reconstruct use history.The total OCPs concentrations ranged 17.74 411.86 ng/g.Dichlorodiphenyltrichloroethane (DDTs) hexachlorocyclohexanes (HCHs) recorded as the dominant components.Historically, contaminations input significant during 1950s with also certainly mid-1960s 1990s corresponding historically...