A5101569778- Intracerebral and Subarachnoid Hemorrhage Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Copper-based nanomaterials and applications
- Advanced Drug Delivery Systems
- Intracranial Aneurysms: Treatment and Complications
- Antimicrobial Peptides and Activities
- Antifungal resistance and susceptibility
- Medicinal Plant Pharmacodynamics Research
- Fungal Biology and Applications
- Sirtuins and Resveratrol in Medicine
- Telomeres, Telomerase, and Senescence
- Gas Sensing Nanomaterials and Sensors
- Natural product bioactivities and synthesis
- Advanced Photocatalysis Techniques
- Plant biochemistry and biosynthesis
- Retinoids in leukemia and cellular processes
- Traditional Chinese Medicine Analysis
Nanchang University
2023-2025
Second Affiliated Hospital of Nanchang University
2023-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Guangdong University of Petrochemical Technology
2024
University of Electronic Science and Technology of China
2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Southwest Medical University
2023
Shanghai Cell Therapy Research Institute
2023
First Affiliated Hospital of Sichuan Medical University
2023
Anhui University of Science and Technology
2015
Abstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are leading causes secondary damage. Removing excess ions ROS in meningeal system can effectively alleviate damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities scavenging ABTS + free radicals solution. intrathecal injection, distribution is...
Abstract: Fatal fungal infections in central nervous system (CNS) can occur through hematogenous spread or direct extension. At present, hydrophobic amphotericin B (AMB) is the most effective antifungal drug clinical trials. However, AMB and therefore penetrates poorly into CNS, therapeutic levels of are hard to achieve. The transferrin receptor (TfR/CD71) located at blood–brain barrier mediates transcytosis. In order enhance receptor-mediated delivery CNS with level, an anti-TfR antibody...
Following intracerebral hemorrhage, mitigating oxidative stress and removing excess iron are critical strategies for reducing secondary brain injury improving neurological outcomes. In vitro, we synthesized quercetin-ethylenediamine carbon quantum dots (QECQDs) with diameters of 2-11 nm found that QECQDs effectively scavenge ABTS+· DPPH· free radicals, defending HT22 cells against hemin-induced stress. vivo, predominantly accumulate in the pia mater, subarachnoid space, dura mater after...
Polygonum perfoliatum L. is an herbal medicine that has been extensively used in traditional Chinese to treat various health conditions ranging from ancient internal surgical and gynecological diseases. Numerous studies suggest P. extract elicits significant anti-tumor, anti-inflammatory, anti-bacterial, anti-viral effects. Nevertheless, the underlying mechanisms of its anti-liver cancer effects remain poorly understood. Our study suggests stem (PPLA) a favorable safety profile exhibits...
Iron overload and oxidative stress are pivotal in the pathogenesis of brain injury secondary to intracerebral hemorrhage (ICH). There is a compelling need for agents that can chelate iron scavenge free radicals, particularly those demonstrate substantial penetration, mitigate ICH-related damage. In this study, we have engineered an amine-functionalized aspirin-derived carbon quantum dot (NACQD) with nominal diameter 6–13 nm. The NACQD possesses robust iron-binding antioxidative capacities....
Abstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are leading causes secondary damage. Removing excess ions ROS in meningeal system can effectively alleviate damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities scavenging ABTS+ free radicals solution. intrathecal injection, distribution is...