Yang Chen

ORCID: 0000-0002-4722-279X
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About
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Research Areas
  • Coronary Interventions and Diagnostics
  • Cardiac Imaging and Diagnostics
  • Cancer-related molecular mechanisms research
  • Peripheral Artery Disease Management
  • Orthopaedic implants and arthroplasty
  • Acute Myocardial Infarction Research
  • Lipoproteins and Cardiovascular Health
  • Total Knee Arthroplasty Outcomes
  • Antioxidant Activity and Oxidative Stress
  • Cerebrovascular and Carotid Artery Diseases
  • Gallbladder and Bile Duct Disorders
  • Pediatric Hepatobiliary Diseases and Treatments
  • Orthopedic Infections and Treatments
  • Urinary Bladder and Prostate Research
  • Pelvic floor disorders treatments
  • Cardiac Arrhythmias and Treatments
  • Helicobacter pylori-related gastroenterology studies
  • Ferroptosis and cancer prognosis
  • Gout, Hyperuricemia, Uric Acid
  • Pancreatitis Pathology and Treatment
  • Cancer, Lipids, and Metabolism
  • Hip disorders and treatments
  • Spine and Intervertebral Disc Pathology
  • Gastroesophageal reflux and treatments
  • Hair Growth and Disorders

Tianjin Hospital
2012-2025

Ningxia Medical University General Hospital
2025

Ningxia Medical University
2025

Air Force Medical University
2025

Xijing Hospital
2021-2025

Jilin Agricultural University
2025

Czech Academy of Sciences, Institute of Physics
2024

Huadong Hospital
2022-2024

Fudan University
2022-2024

Nanchang University
2020-2024

<h3>Importance</h3> Epidemiological studies support a link between low 25-hydroxyvitamin D levels and higher risk of viral upper respiratory tract infections. However, whether winter supplementation vitamin reduces the among children is unknown. <h3>Objective</h3> To determine high-dose vs standard-dose incidence wintertime infections in young children. <h3>Design, Setting, Participants</h3> A randomized clinical trial was conducted during months September 13, 2011, June 30, 2015, aged 1...

10.1001/jama.2017.8708 article EN JAMA 2017-07-18

Abstract Triglyceride glucose index (TyG) and waist circumstance have been well documented to be highly correlated with hypertension. However, the joint effect of TyG on risk hypertension is unknown in middle-aged elderly Chinese adults. The purpose this study was investigate association between new-onset individuals different circumstances. multicentred prospective cohort conducted 28 provinces China including a total 5865 eligible participants aged ≥ 45 years old. Cox regression performed...

10.1038/s41598-024-52342-7 article EN cc-by Scientific Reports 2024-01-26

Left bundle branch area pacing (LBBAP) has developed in an effort to improve cardiac resynchronization therapy (CRT). We aimed compare the long-term clinical outcomes between LBBAP and biventricular (BIVP) patients with heart failure (HF) complete left block (CLBBB). Consecutive HF CLBBB requiring CRT received either or BIVP were recruited at Second Affiliated Hospital of Nanchang University from February 2018 May 2019. assessed their implant parameters, electrocardiogram (ECG), during...

10.1007/s00380-021-02016-5 article EN cc-by Heart and Vessels 2022-01-28

The hair follicle (HF) cycle is a complicated and dynamic process in mammals, associated with various signaling pathways gene expression patterns. Non-coding RNAs (ncRNAs) are RNA molecules that not translated into proteins but involved the regulation of cellular biological processes. This study explored relationship between ncRNAs HF by developing synchronization model Angora rabbits. Transcriptome analysis was performed to investigate mRNAs stages cycle. One hundred eleven long non-coding...

10.3389/fgene.2019.00407 article EN cc-by Frontiers in Genetics 2019-05-03

Previous studies have shown a clear link between insulin resistance (IR) and an elevated risk of atrial fibrillation (AF). However, the relationship estimated glucose disposal rate (eGDR), which serves as marker for IR, AF recurrence after radiofrequency catheter ablation (RFCA) remains uncertain. Therefore, this study aimed to examine potential association eGDR following RFCA.

10.1186/s40001-024-01911-7 article EN cc-by European journal of medical research 2024-06-12

Abstract Background This study aimed to estimate the influence of continuous and cluster nursing on carpal tunnel syndrome (CTS) release surgery. Methods Ninety-six patients with CTS were treated in our hospital from November 2019 December 2021. These randomly divided into two groups 48 patients. Both underwent open The control group received routine care, while a combination interventions. Boston question, Visual Analogue Scale (VAS), Numerical Rating (NRS), Pittsburgh Sleep Quality Index...

10.1186/s13018-024-05246-1 article EN cc-by Journal of Orthopaedic Surgery and Research 2025-01-07

To establish a rapid and sensitive detection method for the porcine reproductive respiratory syndrome virus (PRRSV), gene-specific primers TaqMan probe were designed based on M gene of PRRSV, new stable fully pre-mixed reverse transcription real-time fluorescence quantitative PCR (RT-qPCR) reaction mixture was developed. A simple RT-qPCR PRRSV developed by optimizing nucleic acid amplification conditions. The results showed that able to specifically detect without cross-reactivity with other...

10.3390/vetsci12010026 article EN cc-by Veterinary Sciences 2025-01-07

Sivelestat may reduce postoperative pulmonary injury after total arch replacement (TAR). This study aimed to evaluate whether the preoperative PaO2/FiO2 (P/F) ratio affects efficacy of sivelestat in reducing patients with acute aortic dissection (AAD) who underwent TAR using deep hypothermic circulatory arrest (DHCA). Data AAD DHCA a tertiary hospital between February 1, 2022, and December 30, were retrospectively reviewed. The divided into control groups. Three subgroup analyses performed...

10.1186/s12872-025-04527-9 article EN cc-by-nc-nd BMC Cardiovascular Disorders 2025-02-20

Background: Multiple myeloma (MM) is the second most common hematologic malignancy worldwide and does not have sufficient prognostic indicators.FCER1G (Fc fragment Of IgE receptor Ig) located on chromosome 1q23.3and involved in innate immunity.Early studies shown that FCER1G participates many immune-related pathways encompassing multiple cell types.Meanwhile, it associated with malignancies.However, relationship between MM has been studied.Methods: In this study, we integrated nine...

10.7150/jca.37313 article EN cc-by-nc Journal of Cancer 2019-12-13

This study aimed to explore the clinical characteristics and outcomes of placental abruption. A total 62 abruption cases were collected from Second Hospital Jilin University between January 2007 December 2012. retrospective was conducted risk factors for abruption, characteristics, maternal fetal outcomes. Risk mainly include preeclampsia (39%) premature rupture membrane (10%). Abdominal pain (68%) bleeding (35%) comprise classical symptoms but picture varies asymptomatic, in which diagnosis...

10.1016/j.tjog.2019.01.010 article EN cc-by-nc-nd Taiwanese Journal of Obstetrics and Gynecology 2019-03-01

Immune checkpoint inhibitor (ICI) therapy has achieved remarkable clinical benefit in melanoma and non-small cell lung cancer (NSCLC). Tumor mutational signatures are the fingerprints of endogenous exogenous factors that have acted throughout tumorigenesis heterogeneity; however, their association with immune response ICI-treated samples remains unclear. Here, we leveraged whole-exome sequencing (WES)-based profiles combined clinicopathologic characteristics from NSCLC datasets to examine...

10.1016/j.omtn.2020.10.033 article EN cc-by-nc-nd Molecular Therapy — Nucleic Acids 2020-10-27

Immune and stromal component evaluation is necessary to establish accurate prognostic markers for the prediction of clinical outcomes in lung adenocarcinoma (LUAD). We aimed develop a gene signature based on Estimation STromal cells MAlignant Tumor tissues using Expression data (ESTIMATE)-stromal-immune score LUAD.The transcriptomic profiles patients with LUAD were obtained from The Cancer Genome Atlas (TCGA), immune scores derived ESTIMATE algorithm. genes selected differentially expressed...

10.21037/tlcr-21-223 article EN Translational Lung Cancer Research 2021-03-01

Background: Yiqi Huoxue Decoction (YQHXD) is a traditional Chinese medicine that promotes blood circulation, removes stasis, facilitates diuresis, and alleviates edema. It composed of 10 herbal medicines has extensive application in treating nephrotic syndrome (NS). However, the active components potential mechanism YQHXD for NS remain unclear. Methods: We set up sensitive rapid method based on Ultra-High Performance Liquid Chromatograph-Mass (UPLC-MS) to identify compounds constituents...

10.3389/fphar.2021.775745 article EN cc-by Frontiers in Pharmacology 2022-02-24

Abstract During the COVID-19 pandemic it was widely described that certain individuals infected by SARS-CoV-2 experience persistent disease signs and symptoms, Long COVID, which in some cases is very severe with life changing consequences. To maximize our chances of identifying underpinnings this illness, we have focused on 121 most from &gt;1000 patients screened specialized clinics Sweden Belgium. We restricted study to subjects objective measures organ damage or dysfunction, &gt;3 months...

10.1101/2024.02.11.24302636 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2024-02-13

Concurrent chemoradiotherapy (CCRT), especially platinum plus radiotherapy, is considered to be one of the most promising treatment modalities for patients with advanced esophageal cancer. STAT3β regulates specific target genes and inhibits process tumorigenesis development. It also a good prognostic marker potential response adjuvant (ACRT). We aimed investigate relationship between CCRT. examined expression STAT3α in pretreatment tumor biopsies 105 ESCC who received CCRT by...

10.3390/cancers13040901 article EN Cancers 2021-02-21
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