A5101778125- Neonatal Health and Biochemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Supercapacitor Materials and Fabrication
- Hepatocellular Carcinoma Treatment and Prognosis
- Artificial Intelligence in Healthcare and Education
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Graphene research and applications
- CAR-T cell therapy research
- Metabolism and Genetic Disorders
- Advanced Sensor and Energy Harvesting Materials
- Ubiquitin and proteasome pathways
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Music Therapy and Health
- Retinopathy of Prematurity Studies
- Hand Gesture Recognition Systems
- Advanced battery technologies research
- Graphene and Nanomaterials Applications
- Social and Behavioral Studies
- Gaze Tracking and Assistive Technology
- Biomedical Research and Pathophysiology
Southern Medical University
2024-2025
Zhujiang Hospital
2024-2025
Guangzhou Medical University
2016-2024
Anhui Agricultural University
2024
Shantou University
2015-2024
Henan Provincial People's Hospital
2024
Henan University
2024
Zhengzhou University
2021-2024
Second Affiliated Hospital of Guangzhou Medical University
2019-2024
South China University of Technology
2022-2024
Abstract The severe Zn‐dendrite growth and insufficient carbon‐based cathode performance are two critical issues that hinder the practical applications of flexible Zn‐ion micro‐ssupercapacitors (FZCs). Herein, a self‐adaptive electrode design concept synchronous improvement on both anode is proposed to enhance overall FZCs. Polypyrrole doped with anti‐expansion graphene oxide acrylamide (PPy/GO‐AM) side can exhibit remarkable electrochemical performance, including decent capacitance cycling...
Background: Multiple myeloma (MM) is the second most common hematologic malignancy worldwide and does not have sufficient prognostic indicators.FCER1G (Fc fragment Of IgE receptor Ig) located on chromosome 1q23.3and involved in innate immunity.Early studies shown that FCER1G participates many immune-related pathways encompassing multiple cell types.Meanwhile, it associated with malignancies.However, relationship between MM has been studied.Methods: In this study, we integrated nine...
In this study, 245 representative samples of aquatic products were selected from local markets in Shenzhen by stochastic sampling. The comprised eight species and fell into three product categories: fish, crustaceans, bivalves. A total BPs determined liquid chromatography coupled with mass spectrometry, namely, bisphenol (BPA), AF (BPAF), AP (BPAP), B (BPB), S (BPS), P (BPP), Z (BPZ), F (BPF). All detected products, except for BPAF, indicating pervasive contamination products. BPS...
Abstract Generative artificial intelligence (AI) holds immense potential for medical applications, but the lack of a comprehensive evaluation framework and methodological deficiencies in existing studies hinder its effective implementation. Standardized assessment guidelines are crucial ensuring reliable consistent generative AI healthcare. Our objective is to develop robust, standardized tailored evaluating performance contexts. Through rigorous literature review utilizing Web Sciences,...
Abstract The molecular mechanism underlying bilirubin neurotoxicity remains obscure. Ubiquitin–proteasome system-mediated proteolysis is pivotal to virtually all cellular processes and cell survival. Here we report for the first time that at a clinically relevant elevated level impairs proteasomal function via inhibiting both 19S proteasome-associated deubiquitinases (USP14 UCHL5) chymotrypsin-like (CT-like) peptidase activity of 20S proteasomes, thereby contributing neurotoxicity. This...
Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation the predominant mechanism of acquired to IM. Therefore, it urgent search for additional approaches targeting strategies overcome resistance. We recently reported nickel pyrithione (NiPT) potently inhibits ubiquitin proteasome system via 19S proteasome-associated deubiquitinases (UCHL5...
XPO1 is an attractive and promising therapeutic target frequently overexpressed in multiple hematological malignancies. The clinical use of inhibitors natural killer/T-cell lymphoma (NKTL) not well documented. Here, we demonstrated that overexpression indicator poor prognosis patients with NKTL. compassionate the inhibitor selinexor combination chemotherapy showed favorable outcomes three refractory/relapsed (R/R) NKTL patients. Selinexor induced complete tumor regression prolonged survival...
Motivated by the advancements in portable and wearable electronics, rising necessity for microscale energy storage electronics has prompted extensive research on efficient cost-effective preparation of high-performance electrode materials. Herein, a facile fabrication method N-doped graphene-based electrodes is demonstrated in-plane microsupercapacitors (MSCs) flexible textile. Our approach involves one-step direct hot stamping 10 s reduction graphene oxide (GO) simultaneously N doping into...
Abstract Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. T315I Bcr-Abl most notorious point mutation to elicit acquired resistance imatinib (IM), leading poor prognosis. Therefore, it urgent search for additional approaches and targeting strategies overcome IM resistance. We recently reported that platinum pyrithione (PtPT) potently inhibits ubiquitin–proteasome system (UPS) via 26 S proteasome-associated deubiquitinases (DUBs), without effecting...
Secondary hemophagocytic lymphohistiocytosis (SHLH) is a potentially fatal hyperinflammatory syndrome with heterogeneous etiology and has nonspecific clinical laboratory findings. The diagnosis treatment of adult SHLH challenging because the disease difficult to identify, majority reported cases are pediatric patients. aim this study was describe etiology, characteristics, outcomes SHLH. Fifty‐four patients who fulfilled criteria were enrolled in study. Viral blood biomarkers, manifestations...
Hyperbilirubinemia may increase the risk of Alzheimer's disease (AD) but its mechanistic role in AD pathogenesis remains obscure. Here, we used animal models to investigate short- and long-term effects neonatal systemic exposure bilirubin on brain histology function as well acute effect lateral ventricle injection adult rats. We found that three days newborn rats could induce AD-like pathological changes late life, including tau protein hyperphosphorylation at multiple sites, increased Aβ...
Purpose . Human papillomavirus (HPV) antigens had been found in colorectal cancer (CRC) tissue, but little evidence demonstrates the association of HPV with oncogene mutations CRC. We aim to elucidate mutated genes that link infection and CRC carcinogenesis. Methods Cancerous adjacent noncancerous tissues were obtained from patients. antigen was measured by using immunohistochemical (IHC) technique. The differentially expressed (DEGs) HPV-positive HPV-negative tumor TaqMan Array Plates....
Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly effectively managed, it can lead to severe bilirubin-induced neurotoxicity. Sunflower seeds are nutrient-rich food source, particularly abundant in linoleic acid. Here, we provide compelling evidence that lactating maternal mice fed sunflower seed diet experience enhanced neurological outcomes increased survival rates hyperbilirubinemic offspring. We assessed histomorphological indices, including...
Objective: Sorafenib is a first-line drug for advanced hepatocellular carcinoma (HCC). Unfortunately, most patients with HCC do not respond to sorafenib, mainly because of the frequent development resistance. Bilirubin an end metabolite heme catabolism and indicator liver function, but its direct role in regulating anticancer activity sorafenib cells unclear. In current study, we aimed investigate mechanism action bilirubin sorafenib-mediated tumor suppression HCC. Methods: A retrospective...
Abstract To study the association between Ava II polymorphism at low‐density lipoprotein receptor (LDL‐R) gene exon 13 locus and chronic hepatitis C virus (HCV) infection in Han Chinese, 84 HCV‐infected patients without anti‐viral treatment, 72 healthy blood donors were studied. Polymerase chain reaction combined with restriction fragment length (PCR‐RFLP) was used to detect LDL‐R locus. The comparisons of genotype distribution allele frequency controls showed statistically significant...
To evaluate the efficacy and toxicity of hypofractionated stereotactic body radiotherapy (SBRT) for patients with recurrent or residual hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE).Between June 2008 July 2015, thirty-three HCC were treated by SBRT. There 63 lesions in 33 patients. A total dose 39-45 Gy/3-5 fractions was delivered to 70-80% isodose line.Objective response rate (CR + PR) 84.8% at 6 months. The overall survival 87.9%, 75.8%, 57.6%, 45.5%...
ABSTRACT In this article, a series of blocked waterborne polyurethanes (BWPUs) were synthesized by isophorone diisocyanate, polyols, dimethylol butanoic acid (DMBA), and 3,5‐dimethylpyrazole. BWPUs applied to digital inkjet printing textiles. The successful synthesis deblocking BWPU confirmed Fourier transform infrared spectroscopy differential scanning calorimetry. colorfastness was improved the terminal NCO groups at 140 °C, which could react with fiber. This article presented...
Generative Artificial Intelligence (AI) holds immense potential in medical applications. Numerous studies have explored the efficacy of various generative AI models within healthcare contexts, but there is a lack comprehensive and systematic evaluation framework. Given that some evaluating ability for applications deficiencies their methodological design, standardized guidelines are also currently lacking. In response, our objective to devise assessment tailored performance systems contexts....