A5018129328- Circadian rhythm and melatonin
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- FOXO transcription factor regulation
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Mechanisms of cancer metastasis
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Phytochemistry and Biological Activities
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
Chinese PLA General Hospital
2021-2025
Air Force Medical University
2015-2024
Beijing Meteorological Bureau
2024
Beijing University of Chinese Medicine
2013-2024
China Meteorological Administration
2023-2024
Weifang People's Hospital
2024
Chinese People's Liberation Army
2022-2023
Chinese General Hospital College of Nursing and Liberal Arts
2023
People's Liberation Army No. 150 Hospital
2022
Peking Union Medical College Hospital
2013-2020
Abstract Auxin is central to many aspects of plant development; accordingly, plants have evolved several mechanisms regulate auxin levels, including de novo biosynthesis, degradation, and conjugation sugars amino acids. Here, we report the characterization an Arabidopsis thaliana mutant, IAA carboxyl methyltransferase1-dominant (iamt1-D), which displayed dramatic hyponastic leaf phenotypes caused by increased expression levels IAMT1 gene. encodes indole-3-acetic acid (IAA) methyltransferase...
Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and mortality rates due to the lack of effective therapy. Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation associated upregulation apoptotic signaling pathway has been implicated in various inflammatory diseases including hemorrhagic insults. Melatonin reported possess substantial anti-inflammatory properties, which beneficial for early brain...
High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but exact mechanisms underlying HACE are not fully understood. Human volunteers ascended to high altitude (3860 m, 2 days), rats were exposed hypoxia in a hypobaric chamber (5000 days). was evaluated by Lake Louise Score (LLS), plasma corticotrophin-releasing hormone (CRH) cytokines TNF-α, IL-1β, IL-6 measured humans. Subsequently,...
Histone deacetylases (HDACs) play crucial roles in cancers, but the role and mechanism of HDAC7 NSCLC have not been fully understood.A total 319 patients with non-small cell lung cancer (NSCLC) who underwent surgery were enrolled this study. Immunohistochemistry Kaplan-Meier survival analysis performed to investigate relationship between HDAC7, fibroblast growth factor 18 (FGF18) expression, clinicopathologic characteristics. Cell functional experiments implemented both vivo vitro effects on...
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells, immune stromal cytokines, and chemokines which together govern progression response to immunotherapies. Methyltransferase-like 3 (METTL3), core catalytic subunit for RNA N6-methyladenosine (m6A) modification, plays crucial role in regulating various physiological pathological processes. Whether how METTL3 regulates the TME anti-tumor immunity non-small-cell lung (NSCLC) remain poorly understood. Here, we...
Hua, the dried rhizome of
Icariin, a major active ingredient in traditional Chinese medicines, is attracting increasing attention because of its unique pharmacological effects against ischaemic heart disease. The histone deacetylase, sirtuin-1, plays protective role ischaemia/reperfusion (I/R) injury, and this study was designed to investigate the icariin models cardiac I/R injury elucidate potential involvement sirtuin-1.