A5101547387- Autophagy in Disease and Therapy
- interferon and immune responses
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Surfactants and Colloidal Systems
- Neuroscience and Neuropharmacology Research
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Prostate Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Hepatitis B Virus Studies
- Botulinum Toxin and Related Neurological Disorders
- Mass Spectrometry Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Ministry of Education of the People's Republic of China
2023-2025
Sun Yat-sen University
2023-2025
Sun Yat-sen University Cancer Center
2023-2025
Beijing Technology and Business University
2022
Xi'an Jiaotong University
2017
Second Military Medical University
2013-2016
Eastern Hepatobiliary Surgery Hospital
2016
Changhai Hospital
2016
Current literature provided information that alteration in microRNA expression impacted sensitivity or resistance of certain tumor types to anticancer treatment, including the possible intracellular pathways. The microRNA-23a (miR-23a)-regulated apoptosis response 5-fluorouracil (5-FU)-induced mitochondria-mediated apoptotic pathway was determined this study. miR-23a 5-FU-treated and untreated colon cancer cells tissues assessed using real-time PCR analysis. To determine function regulation...
Abstract The induction of type-I interferons (IFN-Is) is important for the efficacy chemotherapy. By investigating role amino acids in regulation IFN-I production under chemo-drug treatment bladder cancer (BC) cells, we find an inherent AhR-dependent negative feedback to restrain STING signaling and production. Mechanistically, a ligand dependent manner, AhR bridges CUL4B/RBX1 E3 ligase complex, facilitating degradation through ubiquitin-proteasome pathway. Inhibition increases levels...
Cyclic GMP-AMP synthase (cGAS) binds pathogenic and other cytoplasmic double-stranded DNA (dsDNA) to catalyze the synthesis of cyclic (cGAMP), which serves as secondary messenger activate STING pathway innate immune responses. Emerging evidence suggests that activation cGAS is crucial for anti-tumor immunity; however, no effective intervention method targeting currently available. Here we report palmitoylated by ZDHHC9 at cysteines 404/405, promotes dimerization cGAS. We further identified...
Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which mainly produced activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In tumor microenvironment, itaconate concentrated induces an immunosuppressive response. However, whether can be taken up cells its mechanism of action remain largely unclear. Here, we identified solute carrier family 13 member 3 (SLC13A3) as key protein transporting cells, where it elevates...
β-Ionone, the end ring analog of β-carotenoids, has been proven to have an antitumor effect in a variety cancers. In this study, we investigated impact β-ionone on renal cell carcinoma (RCC) lines (786-O and ACHN) using colony formation assays, flow cytometry analysis, western blot analysis. We found that effectively inhibited proliferation RCC cells vitro, which was also confirmed xenograft model. Moreover, could induce autophagy, as indicated by LC3 puncta 786-O ACHN expression...
Ion-specific effects widely exist in biological and chemical systems cannot be explained by classical theories. The complexity of ion-specific protein at the molecular level necessitates use mimetic models involving smaller molecules, such as amino acids, oligopeptides, other organic molecules bearing amide bonds. Therefore, it is theoretical value to determine effect additional salts on aggregation transitions acyl acid surfactants. Herein, specific tetraalkylammonium ions (TAA+) sodium...
Some studies have shown that painful neuropathy is a common and costly complication of both type 1 2 diabetes mellitus, glutamate involved in the process although mechanisms are not clear. The purpose present study was to investigate effect N-methyl-D-aspartate (NMDA) receptor on mechanical hyperalgesia diabetic rats possible mechanism.Diabetic rat model established by intraperitoneal injection streptozotocin (STZ, 1%, 70 mg/kg) once, evaluated change fasting blood glucose. estimated...
Polybromo 1 (PBRM1) inactivating mutations are associated with clinical benefit from immune checkpoint inhibitor treatments in clear cell renal carcinoma (ccRCC). However, whether targeting PBRM1 has the potential to enhance immunotherapy efficacy patients wild-type and upstream pathways that regulate protein stability remain unclear. Here, it is demonstrated knockdown induced M1 macrophage polarization infiltration, which enhanced of anti-PD-1 RCC. Meanwhile, CDC20 catalyzes K27...
Abstract Aberrant regulation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress pathway is associated with cancer development, metastasis, and relapse, the UPR signal transducer ATF6 has been proposed as a diagnostic prognostic marker for many cancers. However, causal molecular link between activation carcinogenesis not established. Here, it found that tumor D52 (TPD52) integrates ER signaling chaperone machinery by promoting S2P‐mediated cleavage ATF6. Although TPD52...
To develop a simple inflammatory factor-based prognostic risk stratification system for patients with metastatic castration-resistant prostate cancer (mCRPC) receiving docetaxel as the initial treatment, we reviewed data of 399 consecutive who received first-line chemotherapy between January 2013 and June 2019 retrospectively. The optimal cut-off values neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) in terms survival were calculated by ROC curves. Patients stratified into...