A5100619984- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Mast cells and histamine
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Corneal Surgery and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Adenosine and Purinergic Signaling
- interferon and immune responses
- CAR-T cell therapy research
- Drug Transport and Resistance Mechanisms
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Ministry of Education of the People's Republic of China
2023
First Affiliated Hospital Zhejiang University
2023
Shenzhen Institutes of Advanced Technology
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Bioprocessing Technology Institute
2020-2021
Agency for Science, Technology and Research
2020-2021
National University of Singapore
2020-2021
Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which mainly produced activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In tumor microenvironment, itaconate concentrated induces an immunosuppressive response. However, whether can be taken up cells its mechanism of action remain largely unclear. Here, we identified solute carrier family 13 member 3 (SLC13A3) as key protein transporting cells, where it elevates...
Natural killer (NK) cells are innate lymphocytes that directly kill tumor and pathogen-infected upon activation by cytokines NK cell receptors (NKRs) without previous sensitization. It is known metabolism affects the differentiation effector functions of immune cells. For instance, interleukin-2 interleukin-15 treatment increases glycolysis oxidative phosphorylation (OXPHOS) in to support their functions. However, little about metabolic reprogramming human NKRs. In this study, we...
Abstract Natural killer (NK) cell‐based immunotherapy holds prominent potential for cancer treatment. However, its application in solid tumors is limited by a rapid decline viability and function, as well inadequate homing infiltration. Herein, generalized strategy offered to construct bio‐orthogonal targeted live‐cell nanocarrier (N 3 ‐NK‐NPs) coupling with responsive released interleukin‐21 (IL‐21) nanoparticles (ILNPs) on glyco‐engineered NK cell surfaces. Complementary groups (azide...
Cell metabolism plays a pivotal role in regulating the effector functions of immune cells. Stimulatory cytokines, such as interleukin (IL)-2 or IL-12 and IL-15, activate glycolysis oxidative phosphorylation natural killer (NK) cells to support their enhanced functions. IL-10, pleiotropic cytokine, is known suppress macrophage activation but stimulate NK However, it remains unclear if IL-10 has an effect on human so, what metabolic mechanisms are affected, how these changes regulated...
Cyclic GMP-AMP synthase (cGAS) binds pathogenic and other cytoplasmic double-stranded DNA (dsDNA) to catalyze the synthesis of cyclic (cGAMP), which serves as secondary messenger activate STING pathway innate immune responses. Emerging evidence suggests that activation cGAS is crucial for anti-tumor immunity; however, no effective intervention method targeting currently available. Here we report palmitoylated by ZDHHC9 at cysteines 404/405, promotes dimerization cGAS. We further identified...
Abstract Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the signaling various immune receptors, little how maintains homeostasis gut system. Here, we show that BTK-deficiency promotes IBD progression a mouse model colitis. Interestingly, increased colitis susceptibility BTK-deficient mice not...