A5020019844- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Virus-based gene therapy research
- Micro and Nano Robotics
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Molecular Communication and Nanonetworks
- Photodynamic Therapy Research Studies
- Nanowire Synthesis and Applications
- 3D Printing in Biomedical Research
- Click Chemistry and Applications
- Immune Cell Function and Interaction
- Parallel Computing and Optimization Techniques
- Advanced Nanomaterials in Catalysis
- Distributed systems and fault tolerance
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Luminescence and Fluorescent Materials
- Extracellular vesicles in disease
Chinese Academy of Sciences
2016-2025
Shanghai Institute of Materia Medica
2025
Huzhou Vocational and Technical College
2025
Shenzhen Institutes of Advanced Technology
2015-2024
University of Chinese Academy of Sciences
2016-2024
Huazhong Agricultural University
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shenzhen Luohu People's Hospital
2024
Lanzhou University Second Hospital
2024
An active cell membrane-camouflaged nanoparticle, owning to membrane antigens and structure, can achieve special properties such as specific recognition, long blood circulation, immune escaping. Herein, we reported a cancer membrane-cloaked nanoparticle system theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded membrane-coated nanoparticles, ICNPs) exhibit core-shell nanostructure consisting of an ICG-polymeric core shell. ICNPs demonstrated homologous...
Abstract Due to specific immune recognition receptors on the surface of T cells, their membranes are promising mimic nanocarriers for delivering drugs tumor lesions. However, this single targeting strategy potentially compromises therapy efficacy due inter‐ and intra‐heterogeneity tumors. Azide (N 3 ) or bicyclo [6.1.0] nonyne (BCN) modified unnatural sugars can be successfully incorporated into glycans various cells as artificial receptors, which is expected overcome insufficiency...
Abstract Hypoxia in the tumor microenvironment is a major hurdle dampening antitumor effect of photodynamic therapy (PDT). Herein, active photosynthetic bacteria ( Synechococcus 7942, Syne ) are utilized for tumor‐targeted photosensitizer delivery and situ photocatalyzed oxygen generation to achieve photosynthesis‐boosted PDT. Photosensitizer‐encapsulated nanoparticles (HSA/ICG) assembled by intermolecular disulfide crosslinking attached surface with amide bonds form biomimetic system...
Despite its clinical success, chimeric antigen receptor T (CAR T)-cell immunotherapy remains limited in solid tumors, owing to the harsh physical barriers and immunosuppressive microenvironment. Here a CAR-T-cell-based live microrobot (M-CAR T) is created by decorating CAR with immunomagnetic beads using click conjugation. M-CAR Ts are capable of magnetic-acoustic actuation for precision targeting situ activation antitumor immune responses. Sequential endows magnetically actuated anti-flow...
Abstract Micro/nanorobots have the potential to be remotely propelled and manipulated in complex biological fluid organ tissue. However, combination of sophisticated physiological barriers, remote‐controlled navigation, real‐time motion tracking, diagnostic/therapeutic effects are tremendous challenges for application translation. An unique sequential magneto‐actuated optics‐triggered biomicrorobot (AI microrobot) actively targeted cancer treatment is prepared. The AI microrobot consists two...
Abstract Natural killer (NK) cell‐based immunotherapy holds prominent potential for cancer treatment. However, its application in solid tumors is limited by a rapid decline viability and function, as well inadequate homing infiltration. Herein, generalized strategy offered to construct bio‐orthogonal targeted live‐cell nanocarrier (N 3 ‐NK‐NPs) coupling with responsive released interleukin‐21 (IL‐21) nanoparticles (ILNPs) on glyco‐engineered NK cell surfaces. Complementary groups (azide...
A wide array of biocompatible micro/nanorobots are designed for targeted drug delivery and precision therapy largely depending on their self-adaptive ability overcoming complex barriers in vivo. Here, we report a twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling capabilities that can autonomously navigate to inflamed sites gastrointestinal inflammation via enzyme-macrophage switching (EMS). Asymmetrical TBY-robots effectively penetrated the mucus barrier notably enhanced...
Immune checkpoint blockade (ICB) has revolutionized cancer therapy but only works in a subset of patients due to the insufficient infiltration, persistent exhaustion, and inactivation T cells within tumor. Herein, we develop an engineered probiotic (interleukin [IL]-12 nanoparticle Escherichia coli Nissle 1917 [INP-EcN]) acting as living drug factory biosynthesize anti-PD-1 release IL-12 for initiating systemic antitumor immunity through cell cascade regulation. Mechanistically, INP-EcN not...
Small interference RNA (siRNA)-based therapy holds great potential for cancer treatment. However, its clinical application remains unsatisfied due to the lack of a safe and effective delivery system. Aberrantly elevated sialyation on cell membrane has been reported as an attractive target diagnosis therapy. In this study, phenylboronic acid (PBA) was conjugated onto low molecular weight polyethylenimine (PEI1.8k) generate amphiphilic PBA-grafted PEI1.8k (PEI-PBA) nanovector, which designed...
Since avian influenza virus H5N1-induced hypercytokemia plays a key role in acute lung injury, understanding its molecular mechanism is highly desirable for discovering therapeutic targets against H5N1 infection. In the present study, we investigated of autophagy inflammation by using pseudotyped viral particles (H5N1pps). The results showed that H5N1pps significantly induced both A549 human epithelial cells and mouse tissues, which was primarily due to hemagglutinin (HA) virus. Blocking...
One approach to cancer immunotherapy is the repolarization of immunosuppressive tumor-associated macrophages (TAMs) antitumor M1 macrophages. The present study developed galactose-functionalized zinc protoporphyrin IX (ZnPP) grafted poly(l-lysine)-b-poly(ethylene glycol) polypeptide micelles (ZnPP PM) for TAM-targeted immunopotentiator delivery, which aimed at in vivo TAMs outcomes revealed that ROS-inducing ZnPP PM demonstrated specificity vitro and targeting macrophages, elevated level...