High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but exact mechanisms underlying HACE are not fully understood. Human volunteers ascended to high altitude (3860 m, 2 days), rats were exposed hypoxia in a hypobaric chamber (5000 days). was evaluated by Lake Louise Score (LLS), plasma corticotrophin-releasing hormone (CRH) cytokines TNF-α, IL-1β, IL-6 measured humans. Subsequently,...

Abstract Red leaf color is an attractive trait of Malus families, including crabapple ( spp.); however, little known about the molecular mechanisms that regulate coloration. Dihydroflavonols are intermediates in production both colored anthocyanins and colorless flavonols this current study focused on gene expression balance involved relative accumulation these compounds leaves. Levels transcript abundances anthocyanin biosynthetic gene, dihydroflavonol 4-reductase McDFR ) flavonol synthase...

Spatial attention has been widely used to improve the performance of convolutional neural networks. However, it certain limitations. In this paper, we propose a new perspective on effectiveness spatial attention, which is that mechanism essentially solves problem kernel parameter sharing. information contained in map generated by not sufficient for large-size kernels. Therefore, novel called Receptive-Field Attention (RFA). Existing such as Convolutional Block Module (CBAM) and Coordinated...

Summary The ever‐red leaf trait, which is important for breeding ornamental and higher anthocyanin plants, rarely appears in Malus families, but little known about the regulation of biosynthesis involved red leaves. In our study, HPLC analysis showed that concentration leaves, especially cyanidin, was significantly than evergreen transcript level Mc MYB 10 correlated with synthesis between ‘Royalty’ ‘Flame’ cultivars during development. We also found colour cultivar contained R 6 : sequence,...

Chalcone synthase is a key and often rate-limiting enzyme in the biosynthesis of anthocyanin pigments that accumulate plant organs such as flowers fruits, but relationship between CHS expression petal coloration level different cultivars still unclear. In this study, three typical crabapple were chosen based on colors patterns. The two extreme color cultivars, ‘Royalty’ ‘Flame’, have dark red white petals respectively, while intermediate cultivar ‘Radiant’ has pink petals. We detected...

Anthocyanin pigments play many roles in plants, including providing protection against biotic and abiotic stresses. To identify new regulatory genes apple (Malus domestica) that may be involved regulating low temperature induced anthocyanin biosynthesis, we performed RNA-seq analysis of leaves from the 'Gala' cultivar following exposure to a (16 °C). A visible red color appeared on upper content increased significantly after treatment. Genes flavonoid biosynthesis pathway were enriched among...

Neural networks based on convolutional operations have achieved remarkable results in the field of deep learning, but there are two inherent flaws standard operations. On one hand, convolution operation be confined to a local window and cannot capture information from other locations, its sampled shapes is fixed. size kernel fixed k $\times$ k, which square shape, number parameters tends grow squarely with size. It obvious that shape targets various different datasets at locations....

Anthocyanins are secondary metabolites in land plants that contribute to the colors of leaves and flowers, nutritionally valuable components human diet. The DFR gene plays an important role anthocyanin biosynthetic pathway. In this study, we investigated regulation expression different Malus crabapple cultivars show distinct patterns leaf coloration, how it influences accumulation coloration. Specifically, studied ever-red leaved cultivar ‘Royalty’, ever-green ‘Flame’ spring-red ‘Radiant’....

In the process of carbon peak and neutrality, prefabricated buildings have developed rapidly, concept green low has been introduced into field buildings. This paper establishes an information sharing platform based on BIM (Building Information Modeling), RFID (Radio Frequency IDentification), GIS (Geographic System) technologies from supply chain On basis sharing, Stackelberg two-stage game is used to analyze compare overall profit under centralized pricing decision decentralized decision....

Information goods often adopt a subscription-based business model, where customers pay fixed fee to enter into purchase agreement. The up-front payment of the subscription creates sunk cost for members, which may influence their future consumption behavior. Although price adjustment is common strategy employed by providers, it remains unclear how changes in fee—as cost—affect information goods. For this paper, we first leveraged quasi-natural experiment movie service and...

Background Macular edema (ME) is an ophthalmic disease that poses a serious threat to human vision. Anti-vascular endothelial growth factor (anti-VEGF) therapy has become the first-line treatment for ME due its safety and high efficacy. However, there are still cases of refractory macular non-responding patients. Therefore, it crucial develop automated efficient methods predicting therapeutic outcomes. Methods We have developed predictive model surgical efficacy in patients based on deep...

Pigments in plants not only determine their visual characteristics but also play crucial roles photosynthesis, pollinator attraction, and disease resistance. The diverse colors of chili peppers arise from various pigments. However, detailed reports on the genetic metabolic changes these pigments developmental stages colorful are limited. In this study, we analyzed content anthocyanins carotenoids fruits cultivated pepper variety H18 at different growth development stages. Our findings...

Peppers are widely cultivated around the world, yet they suffer from infections caused by Phytophthora capsici fungi throughout year, which severely impacts their yield. The β-1,3-glucanase gene has been shown in previous studies to significantly enhance plants’ ability cope with both biotic and abiotic stresses, including fungal infections. However, its function peppers not reported. In this study, 80 CaBG genes were initially identified, before being filtered down 54 CaBGs peppers,...

Abstract The flavonoid compounds, proanthocyanidins (PAs), protect plants from biotic stresses, contribute to the taste of many fruits, and are beneficial human health in form dietary antioxidants. In this study, we functionally characterized two Malus crabapple R2R3-MYB transcription factors, McMYB12a McMYB12b, which co-regulate PAs anthocyanin biosynthesis. was shown be mainly responsible for upregulating expression biosynthetic genes by binding their promoters, but only partially...

Anthocyanin is a critical factor involved in coloration of plant tissues, but the mechanism how medium pH values affect anthocyanin accumulation woody plants unknown. We analyzed composition and expression elements encoding flavonols biosynthesis underlying different by using three leave color type cultivars. HPLC analysis demonstrated that high treatment induced dramatic decrease concentration cyaniding crabapple leaves. Conversely, up-regulation content flavones flavonols, suggesting low...

Flavonoids are secondary metabolites that play important roles in plant physiology. Despite numerous studies examined the effects of available carbon (C) or nitrogen (N) on flavonoid biosynthesis, mechanism C/N interactive metabolism is still unclear. In this study, we analyzed composition flavonoids and expression levels flavonoid-related genes leaves calli crabapple (Malus spp.) cultivars with different leaf colors grown media ratios. Our results show high ratios induce anthocyanin...

Abstract It is a huge challenge for carbon materials to obtain high volumetric capacitance without sacrificing gravimetric supercapacitors with limited space. Herein, B/N/O co‐doped porous are prepared by one‐step carbonization method using boric acid as the template and boron source, polyacrylamide nitrogen sources. Boric can be closely combined hydrogen bond, so not only give full play role of template, but also achieve content functional groups. Benefiting from bulk density (1.51 g cm −3...

Anthocyanins are plant pigments that contribute to the color of leaves, flowers and fruits, beneficial human health in form dietary antioxidants. The study a transformable crabapple cultivar, 'India magic', which has red buds green mature using mRNA profiling four leaf developmental stages, allowed us characterize molecular mechanisms regulating formation early development subsequent rapid down-regulation anthocyanin biosynthesis. This analysis differential gene expression during revealed...