A5053405056- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Bioactive Natural Diterpenoids Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Emotion and Mood Recognition
- Cancer-related gene regulation
- Digital Media Forensic Detection
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Phytochemical Studies and Bioactivities
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Face recognition and analysis
- Cancer Mechanisms and Therapy
- Plant-based Medicinal Research
- Advances in Cucurbitaceae Research
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
Wuhan University
2022-2025
Zhongnan Hospital of Wuhan University
2022-2025
Guangdong Polytechnic Normal University
2022-2024
State Key Laboratory of Silkworm Genomic Biology
2019
Army Medical University
2019
Southwest Hospital
2019
Southwest University
2019
Hubei University of Medicine
2016-2017
Abstract Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting deubiquitinase, USP8, significantly enhances efficacy of anti-PD-1/PD-L1 through reshaping an inflamed tumor microenvironment (TME). Mechanistically, USP8 inhibition increases PD-L1...
Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion
UFMylation is an emerging ubiquitin-like post-translational modification that regulates various biological processes. Dysregulation of the pathway leads to human diseases, including cancers. However, physiological role in T cells remains unclear. Here, we report mice with conditional knockout (cKO) Ufl1, a E3 ligase, exhibit effective tumor control. Single-cell RNA sequencing analysis shows tumor-infiltrating cytotoxic CD8+ are increased Ufl1 cKO mice. Mechanistically, UFL1 promotes PD-1...
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells, immune stromal cytokines, and chemokines which together govern progression response to immunotherapies. Methyltransferase-like 3 (METTL3), core catalytic subunit for RNA N6-methyladenosine (m6A) modification, plays crucial role in regulating various physiological pathological processes. Whether how METTL3 regulates the TME anti-tumor immunity non-small-cell lung (NSCLC) remain poorly understood. Here, we...
The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governing homeostasis to modulate tumor immunotherapy remain unknown. Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deubiquitinase for PD-1. Mechanistically, USP5 interacts with PD-1, leading deubiquitination stabilization of Moreover,...
Oridonin (Ori), a diterpenoid compound extracted from traditional medicinal herbs, elicits antitumor effects on many cancer types. However, whether Ori can be used in gefitinib-resistant non-small cell lung (NSCLC) cells remains unclear. This study investigated the activity and underlying mechanisms of Ori. Results demonstrated that this dose-dependently inhibited proliferation, invasion, migration NSCLC vitro. also significantly downregulated phosphorylation EGFR, ERK, Akt, expression...
Gastric cancer is the third most frequent cause of cancer‑associated mortality and almost all patients who respond initially to cisplatin (DDP) later develop drug resistance, indicating multi‑drug resistance (MDR) an essential aspect failure treatment. The natural diterpenoid component Oridonin (Ori) has exhibited efficient inhibition in several types human cancer. However, effect potential mechanism Ori‑reversed MDR gastric not been fully elucidated. In present study, it was found that Ori...
<abstract><p>Methods based on deep learning have shown good advantages in skin lesion recognition. However, the diversity of shapes and influence noise disturbances such as hair, bubbles, markers leads to large intra-class differences small inter-class similarities, which existing methods not yet effectively resolved. In addition, most enhance performance recognition by improving models without considering guidance medical knowledge lesions. this paper, we innovatively construct...