A5101496775- Prostate Cancer Treatment and Research
- PI3K/AKT/mTOR signaling in cancer
- Estrogen and related hormone effects
- Pesticide and Herbicide Environmental Studies
- Toxic Organic Pollutants Impact
- Microbial bioremediation and biosurfactants
- Cancer, Lipids, and Metabolism
- Shape Memory Alloy Transformations
- Soil Carbon and Nitrogen Dynamics
- Effects and risks of endocrine disrupting chemicals
- Titanium Alloys Microstructure and Properties
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer-related Molecular Pathways
- Chromium effects and bioremediation
- Advanced materials and composites
- Metabolism, Diabetes, and Cancer
- Algal biology and biofuel production
- Hydrogen Storage and Materials
- Plant Ecology and Soil Science
- High Entropy Alloys Studies
- RNA modifications and cancer
- Weed Control and Herbicide Applications
- Cancer Immunotherapy and Biomarkers
Shanxi Medical University
2024
Zhejiang University
2006-2024
Yantai University
2023-2024
Fujian Normal University
2022-2024
Medical University of South Carolina
2020-2023
MUSC Hollings Cancer Center
2020-2023
Second Affiliated Hospital of Zhejiang University
2022
Harbin Institute of Technology
2018-2019
Harvard University
2013-2019
Dana-Farber Cancer Institute
2013-2019
Abstract Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting deubiquitinase, USP8, significantly enhances efficacy of anti-PD-1/PD-L1 through reshaping an inflamed tumor microenvironment (TME). Mechanistically, USP8 inhibition increases PD-L1...
Pyruvate kinase isoform M2 (PKM2) is an enzyme-catalyzing conversion of phosphoenolpyruvate to pyruvate in the glycolysis pathway. It was demonstrated that PKM2 interacts with tyrosine phosphopeptide, and interaction phosphopeptide affects activity PKM2. Our experiments suggest also active protein (Gao, X., Wang, H., Yang, J. J., Liu, Z. R. (2012) <i>Mol. Cell</i> 45, 598–609). We report here growth signals reciprocally regulate activities by different mechanisms. On one hand, induce...
PFKP (phosphofructokinase, platelet), the major isoform of PFK1 expressed in T cell acute lymphoblastic leukemia (T-ALL), is predominantly cytoplasm to carry out its glycolytic function. Our study showed that a nucleocytoplasmic shuttling protein with functional nuclear export and localization sequences (NLSs). Cyclin D3/CDK6 facilitated translocation by dimerization exposing NLS induce interaction between importin 9. Nuclear stimulated expression C-X-C chemokine receptor type 4 (CXCR4),...
Hepcidin is one of the regulators iron metabolism. The expression hepcidin induced in spleens and livers mice infected with pathogenic bacteria. Recent studies have indicated that serum level also increased human subjects Plasmodium falciparum. mechanism regulation its role infection malaria remains unknown. In this study, we determined berghei. liver was upregulated downregulated during early late stages infection, respectively. Inflammation erythropoietin, rather than iron-sensing pathway,...
In situ synthesis of multiwalled carbon nanotubes (MWCNTs) was performed by chemical vapor deposition methane on a LaNiO3 perovskite-type growth-promoter prepared the sol–gel method. The as-produced MWCNTs were purified via two-step procedure consisting an oxidation in air and subsequent HNO3 treatment. Nearly monodisperse cobalt nanoparticles with average size 11.3 nm have been successfully decorated impregnation–reduction properties (CNTs) Co/CNT catalysts analyzed X-ray diffraction (XRD),...