A5019414279- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Prostate Cancer Treatment and Research
- Hepatitis C virus research
- Viral Infections and Vectors
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- interferon and immune responses
Anhui Medical University
2022-2023
First Hospital of Jilin University
2022
Jilin University
2022
Second Hospital of Anhui Medical University
2022
The cGAS-STING pathway is essential for immune defense against microbial pathogens and malignant cells; as such, STING an attractive target cancer immunotherapy. However, systemic administration of agonists poses safety issues while intratumoral injection limited by tumor accessibility. Here, we generated antibody-drug conjugates (ADCs) conjugating a agonist through cleavable linker to antibodies targeting cells. Systemic these ADCs was well tolerated exhibited potent antitumor efficacy in...
The differential expressed genes (DEGs) were screened from the gene expression profile GSE30994 related to PRAD and then analyzed by protein-protein interaction (PPI) screen hub gene. Subsequently, relation between pan cancers, prognosis, immunotherapy was analyzed. Besides, effects of on growth metastasis cell lines inflammatory factors (IFs) detected functional experiments. 276 upregulated 1,861 downregulated DEGs profiles. Through enrichment analysis, it found that significantly enriched...