A5038440124- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Bone fractures and treatments
- Immune cells in cancer
- Dental Health and Care Utilization
- Dental Implant Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Laser Applications in Dentistry and Medicine
- Biomarkers in Disease Mechanisms
- Estrogen and related hormone effects
Guangzhou Medical University
2018-2025
Stomatology Hospital
2018-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2025
Tianjin University of Science and Technology
2016-2021
Tianjin University
2016-2020
Guangzhou Institute of Dermatology
2020
Case Western Reserve University
2019
Cornell University
2019
KU Leuven
2015-2016
Academic Center for Dentistry Amsterdam
2014-2016
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to via and gastrointestinal routes. The S-glycoprotein in the virus key factor for entry of SARS-CoV-2 into cell, which contains two functional domains: S1 an angiotensin-converting enzyme (ACE2) receptor binding domain, S2 necessary fusion cell membranes. Moreover, it has been reported ACE2 likely be SARS-CoV-2. In addition, mRNA level...
Background Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells CRC TME and play a vital role progression metastasis. Most studies have focused on investigating of cell-specific progression, while contribution TAMs-specific still unknown. Here, we sought to investigate expression pattern TAMs its immunity progression. Methods patterns paratumor or...
The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study aimed to investigate the occurrence ferroptosis in alveolar osteocytes during periodontitis therapeutic potential resveratrol alleviate osteocyte ferroptosis. Diabetic was induced C57/BL6-male mice treated with or without resveratrol. Periodontitis pathogenicity analyzed by micro-CT histology, immunohistochemistry. MLOY4 were P. gingivalis-derived lipopolysaccharide (LPS)+advanced...
Abstract Background Restoration of salivary gland function in Sjogren’s syndrome (SS) is still a challenge. Dental pulp stem cells (DPSCs) derived exosomes had shown anti-inflammatory, anti-oxidative, immunomodulatory, and tissue restorative abilities. However, the restoration potential DPSCs-derived (DPSC-Exos) during SS has not been investigated yet. Methods DPSC-Exos was isolated by ultracentrifugation methods characterized. Salivary epithelial (SGEC) were treated with interferon-gamma...
Introduction: Periodontitis is a chronic inflammatory oral disease that destroys soft and hard periodontal support tissues. Multiple cell death modes including apoptosis, necroptosis, pyroptosis, ferroptosis play crucial role in the pathogenicity of diseases. This study aimed to identify genes associated with ferroptosis, pyroptosis different cells present periodontium periodontitis patients. Methods: Gingival tissues' mRNA sequencing dataset GSE173078 12 healthy control patients' microarray...
Abstract Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, bioflavonoid, has shown potent anti‐inflammatory effects. However, its effect on preventing OA progression and underlying mechanisms are still unclear. In this study, Sprague–Dawley male rats were divided into five groups: control group, group (monosodium iodoacetate intra‐articular injection), three quercetin‐treated groups. Quercetin‐treated groups treated with intragastric...
Inflammation and loss of articular cartilage are considered the major cause temporomandibular joint osteoarthritis (TMJOA), a painful condition (TMJ). To determine TMJ in these patients, synovial fluid TMJOA patients was compared prior to after hyaluronic lavage, revealing substantially elevated levels interleukin (IL) 1β, reactive oxidative stress (ROS), an overload Fe
Abstract Background Hypoxia in the vicinity of bone defects triggers osteogenic differentiation precursor cells and promotes healing. The activation STAT3 signaling mesenchymal stem (MSCs) has similarly been reported to mediate regeneration. However, interaction between hypoxia during defect healing is still unknown. Methods In this study, we assessed impact different durations CoCl 2 -induced cellular on MSCs. Role induced was analyzed both vitro vivo. vivo investigated a mouse femoral...
Early diagnosis and treatment of oral cancer are vital for patient survival. Since the cavity accommodates second largest most diverse microbiome community after gut, diagnostic therapeutic approaches with low invasiveness minimal damage to surrounding tissues keys preventing clinical intervention-related infections. Gold nanoparticles (AuNPs) widely used in research therapy due their excellent properties such as surface-enhanced Raman spectroscopy, surface plasma resonance, controlled...
Pleurocidin-family cationic antimicrobial peptide NRC-03 exhibits potent and selective cytotoxicity towards cancer cells. However, the anticancer effect of in oral squamous cell carcinoma (OSCC) molecular mechanism induced death is still unclear. This study focused to investigate mitochondrial oxidative stress-mediated altered function involved NRC-03-induced apoptosis OSCC entered cells more easily than that normal bound mitochondria as well nucleus, causing membrane blebbing, swelling, DNA...
Salivary biomarkers hold huge potential for the non-invasive diagnosis of oral squamous cell carcinoma. Angiogenic factors and matrix-metalloproteinases (MMPs) are highly expressed in OSCC tissue, but their expression patterns saliva unknown. This study aimed to analyze levels angiogenic MMPs tumor tissue patients.OSCC-tissue, adjacent normal (ANT), from patients, healthy controls were obtained. The analyzed by immunohistochemistry, protein chip array, RT-qPCR.Results showed higher ANG,...