A5100374144- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Hydrogen's biological and therapeutic effects
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Effects of Radiation Exposure
- Natural Compounds in Disease Treatment
- Bone fractures and treatments
- Cell death mechanisms and regulation
- Adipose Tissue and Metabolism
- Prenatal Substance Exposure Effects
- Molecular Biology Techniques and Applications
- Leprosy Research and Treatment
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Advancements in Transdermal Drug Delivery
Chengdu University of Traditional Chinese Medicine
2024
Third Xiangya Hospital
2010-2024
Central South University
2010-2024
Capital Medical University
2020-2024
Tianjin First Center Hospital
2023
Tianjin Medical University
2018-2023
China Medical University
2023
Tengzhou Central People's Hospital
2019-2021
Jining Medical University
2021
Ninth Hospital of Nanchang
2020
The expression pattern and function of miRNAs in the rat model temporal lobe epilepsy have not been well defined. Profiling miRNA investigating specific offers prospect a deeper understanding mechanisms epilepsy.
Recent studies have shown that DNA methylation in the promoter of microRNA-375 (miR-375) downregulates its expression during tumorigenesis. However, it is not known if CpG miR-375 also has a role pathogenesis type 2 diabetes mellitus (T2DM). In this study, level and status patients with T2DM were analyzed. Plasma samples from 100 healthy controls normal glucose tolerance (NGT) collected. The plasma levels examined using quantitative polymerase chain reaction (qPCR) 17 sites determined...
Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements hydrogen (H 2 ) gas offer promising therapeutic approach for ischemia reperfusion injury; however, the impact this HIE remains subject debate. We assessed effects H on and underlying molecular mechanisms rat model neonatal brain injury (HIBI). inhalation significantly attenuated neuronal effectively improved early neurological outcomes HIBI rats as well...
Chlorpyrifos (CPF), one of organophosphorus pesticides (OPs), is associated with developmental neurotoxicity. Inflammatory response closely related CPF-induced The present study aimed at exploring whether sub-toxic CPF exposure on neonatal rats results in neuroinflammation that mediated by HMGB1/TLR4/NF-κB signaling pathway the amygdala. were subcutaneously injected 5mg/kg for 4 consecutive days (postnatal day 11-14) or without HMGB1 inhibitor, glycyrrhizin. We assessed levels...
Glioblastoma multiforme (GBM), WHO grade IV astrocytoma, is the most common primary neoplasm of central nervous system (CNS) and has highest malignancy mortality rates. The invasive nature GBM complicates surgical resection restricts chemotherapeutic access, contributing to poor patient prognosis. migration tumor cells closely related cell proliferation. acquisition migratory capability, in addition intracellular factors, proposed be a crucial mechanism during progression invasion. Using...
Cisplatin is a common used chemotherapeutic drug for the treatment of laryngeal cancer. However, drug-resistance major obstacle in platinum-based chemotherapy Recent studies have demonstrated that dysregulation microRNAs (miRNAs) responsible chemoresistance multiple cancers including cancer, but potential mechanisms are required to be explored. In present study, we constantly exposed cancer cell line Hep-2 with cisplatin establish cisplatin-resistant model (Hep-2/R). We found Hep-2/R cells...
Triptolide (TP), a major active component of the herb Tripterygium wilfordii Hook F, has been shown excellent pharmacological effects on rheumatoid arthritis. However, TP is prone to causing severe organ toxicity, which limits its clinical application. In recent years, microneedle technology provided new option for treatment arthritis due advantages efficient local transdermal drug delivery. this study, we constructed platform deliver locally joints, thereby enhancing penetration and...
Abstract We investigated that microRNA (miRNA)‐141 protects against epilepsy‐induced apoptosis and its reaction mechanism. The serum expression of miRNA‐141 in epilepsy model mice control volunteer was measured by quantitative reverse‐transcription polymerase chain reaction. found upregulated patients with epilepsy. Overexpression induced nerve cell apoptosis, suppressed proliferation, promoted caspase‐3/9, Bax p53 protein expression, reduced silent information regulator 1 (SIRT1) vitro...
Increasing evidence suggests that microRNAs (miRNAs) play critical roles in bladder tumorigenesis and development by combining with the 3' untranslated regions (3'-UTRs) of corresponding mRNAs to negatively regulate gene expression. The role miR-182-5p cancer (BC) remains unclear. Therefore, this study aimed clarify functional BC. We predicted candidate for via three databases (TarBase, ENCORI, miRDB). Dual-luciferase reporter assays target prediction confirmed FOXF2 as a potential...
Han population is six times as likely Kazak to present with type 2 diabetes mellitus (T2DM) in China. We hypothesize that differential expression and CpG methylation of miR-375 may be an ethnic-related factor influences the incidence T2DM. The level was examined using real-time PCR on T2DM plasma samples. Furthermore, levels sites promoter were determined by MassARRAY Spectrometry these relative samples are 1, 3. mean methylation, calculated from sites, 8.47% for group 10.38% group. Further,...
Hypoxic–ischemic brain damage (HIBD) is one of the leading causes injury in infant with high risk mortality and disability; therefore, it important to explore more feasible effective treatment strategies. Here, we assessed neuroprotective effects different hydrogen inhalation times for HIBD. We induced hypoxia–ischemia Sprague–Dawley rats (postnatal day 7, both sexes), followed by 30, 60, or 90 min. Morphological was Nissl TUNEL staining. Acute inflammation evaluated examining expression...
N-acetyl-p-aminophenol (APAP)-induced liver injury is a major clinical challenge worldwide. The present study investigated the molecular role of microRNA (miR)-338-3p in development APAP-induced acute injury.
Recent genome-wide association studies (GWAS) have identified a strong signal of microRNA137 host gene (MIR137) with schizophrenia. MIR137 dysfunction results in downregulation presynaptic target complexin 1 (CPLX1) and impairs synaptic plasticity the hippocampus. In this study, we aimed to investigate whether variants CPLX1 confer susceptibility schizophrenia Han Chinese. This study employed 736 patients 751 well-matched healthy subjects for genetic analysis, genotyped 12 SNPs within CPLX1....
Human umbilical cord mesenchymal stem cells can be obtained from different parts of the cord, including Wharton's jelly. Transplantation jelly (WJCMSCs) is a promising strategy for treatment various diseases. However, molecular mechanisms underlying proliferation WJCMSCs are incompletely understood. Here, we report that overexpression miR-196b-5p in suppresses and arrests cell cycle G0/G1 phase, whereas knockdown promotes WJCMSC cell-cycle progression. Moreover, resulted decreased levels...
Hepatic ischemia–reperfusion IR (HIR) is an unavoidable pathophysiological process during liver transplantation, resulting in systematic sterile inflammation and remote organ injury. Acute lung injury (ALI) a serious complication after transplantation with high postoperative morbidity mortality. However, the underlying mechanism still unclear. To assess phenotype plasticity of various cell types tissue microenvironment HIR at single-cell level, RNA sequencing (scRNA-seq) was performed using...
Prostatic cancer (PCa) is a prevalent form of malignancy based on its high associated levels mortality and morbidity across the world. MicroRNAs (miRNAs) are significant in advancement prostatic cancer. The current study aimed at exploring potential roles miR-373 PCa. In turn, conducted qRT-PCR test to determine mRNA. A western blot was also executed determining protein level. processes transwell assay wound healing were integrated detection for PCa cells invade migrate. integration dual...