A5101730662- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- RNA regulation and disease
- RNA Research and Splicing
- Immune cells in cancer
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
Tianjin Medical University
2017-2020
Background Diabetes mellitus (DM) is linked to an increased risk of lung cancer; however, the exact molecular basis unclear. Methods We used a microarray method and found group microRNAs differently expressed in cancer cells at high or low glucose treatment. Results Among these, miR‐194 changed significantly, which indicated further analysis. was significantly downregulated non‐small cell (NSCLC) cultured (HG) medium clinical NSCLC tissues with DM. The introduction suppressed proliferation,...
Abstract Aims/Introduction To evaluate the diagnostic value of microribonucleic acid (miR) as biomarkers in patients with diabetic kidney disease ( DKD ). Materials and Methods A total 230 diabetes mellitus 53 healthy participants were enrolled, group was further divided into normoalbuminuria, microalbuminuria large amount albuminuria group. MiRs serum urine quantificated using real‐time polymerase chain reaction. General clinical information collected analyzed for risk factors. Cut‐off...
Background: The underlying mechanisms by which diabetes and dyslipidemia contribute to diabetic nephropathy (DN) are not fully understood. In this study, we aimed investigate the role of high glucose (HG) on intracellular cholesterol accumulation in glomerular endothelial cells (GEnCs) its potential mechanism. Methods: Oil red O staining, RT-qPCR, Western blotting Immunocytofluorescence analyses were used determine expressions LXRs ABCA1 GEnCs under and/or conditions, effect these treatments...