A5100336160- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Congenital Heart Disease Studies
- Infant Nutrition and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sperm and Testicular Function
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- nanoparticles nucleation surface interactions
- Reproductive Health and Technologies
- Neonatal and Maternal Infections
- Assisted Reproductive Technology and Twin Pregnancy
- Esophageal and GI Pathology
- Airway Management and Intubation Techniques
- Pediatric health and respiratory diseases
- Heart Failure Treatment and Management
- Asthma and respiratory diseases
- Neonatal and fetal brain pathology
- Material Dynamics and Properties
- Cystic Fibrosis Research Advances
Shandong First Medical University
2020-2025
Shandong Provincial Hospital
2015-2025
McMaster University
2025
Impact
2025
Shandong University
2014-2024
Shandong Maternal and Child Health Hospital
2023-2024
Shandong Women’s University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Third Affiliated Hospital of Zhengzhou University
2024
State Key Laboratory of Reproductive Medicine
2023
Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays extensive placental involvement or damage with the presence organisms. The inflammatory processes are complicated tightly associated increased cytokine levels innate immune activation. However, deep study underlying mechanisms was limited by conventional cell animal models because great variations in architecture function placenta. Here, we established microengineered model human barrier on chip...
The early detection and differential diagnosis of respiratory infections increase the chances for successful control COVID-19 disease. nucleic acid RT-PCR test is regarded as current standard molecular diagnosis. However, maximal specificity confirmation target ORF1ab gene considered to be less sensitive than other targets in clinical application. In addition, recent evidence indicated that initial missed asymptomatic patients with SARS-CoV-2 discharged “re-examination positive” might due...
Abstract Background The relationship between antenatal corticosteroids (ACS) and preterm infants born to mothers with hypertensive disorders of pregnancy (HDP) remains a subject debate. To evaluate whether the use ACS before delivery was associated neonatal outcomes in very HDP. Methods This multicenter cohort study enrolled all gestational age at 24 31 week admitted tertiary NICUs Chinese Neonatal Network (CHNN) within h birth from 2019 2021. administration defined as least one dose...
Objective: To analyze the incidence and perinatal factors of death or severe intraventricular hemorrhage (sIVH) within first week life in preterm infants with gestational age <32 weeks. Methods: Based on online data platform Sina-northern Neonatal Network (SNN), a case-control study was conducted using clinical from 8 903 weeks admitted to 35 neonatal intensive care units (NICU) between 2019 2023. Infants were classified by at birth into very extremely infants. who died developed sIVH...
The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants multiple intensive care units (NICUs) China.Since January 1, 2018, a homogeneous cooperative research platform-Shandong Neonatal Network (SNN) has been established. platform collects clinical data prospective manner on preterm with birth weights (BWs) < 1500 g gestational ages (GAs) 34 weeks born...
The present study was designed and conducted to compare the efficacy between nasal continuous positive airway pressure (NCPAP), intermittent positive-pressure ventilation (NIPPV), noninvasive high-frequency oscillatory (NHFOV) as primary in preterm infants with respiratory distress syndrome (RDS).This multicenter retrospective cohort performed using data from four tertiary neonatal intensive care units (NICUs) China 2016 2018. 512 RDS who received early non-invasive (NIV) were analyzed....
Abstract Noninvasive ventilation has been proven to be effective strategies for reducing the need endotracheal in preterm infant with respiratory distress syndrome (RDS), however best option needs further determined. A single center, paired design, randomized, controlled trial was conducted between Jan 2011 and July 2014. Preterm twins RDS were included. One of a pair randomized NIPPV, while another NCPAP. Surfactant administrated as rescue treatment. The primary outcome ventilation....
Objective: Multiple studies have highlighted that long non-coding RNAs (lncRNAs) may exert paramount roles in relieving bronchopulmonary dysplasia (BPD). The aim of our investigation is to probe the role and mechanism lncRNA taurine upregulated gene 1 (TUG1) BPD. Methods: current mouse model BPD was simulated by induction hyperoxia, hyperoxia-induced type II alveolar epithelial (MLE-12) cells were established as a cellular model. Quantitative real-time polymerase chain reaction (qRT-PCR)...
Background: Bronchopulmonary dysplasia is a common pulmonary disease in newborns and one of the main causes death. The aim this study was to build new simple-to-use nomogram screen high-risk populations. Methods: In single-center retrospective performed from January 2017 December 2020, we reviewed data on very-low-birth-weight infants whose gestational ages were below 32 weeks. LASSO regression used select variables for risk model. Then, multivariable logistic prediction model incorporating...
Objective To evaluate the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels along with spontaneous breathing trial (SBT) in prediction ventilator weaning outcome among respiratory distress syndrome (RDS) preterm infants ready to wean. Methods NT-proBNP plasma albumin concentration, serum sodium, potassium, and hematocrit were measured immediately before SBT (≤32 weeks) mechanically ventilated due RDS. Extubation was considered successful if remained extubated >48 hr....
Objectives: To investigate the association between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) level on first day of life and a composite outcome bronchopulmonary dysplasia (BPD) or death in cohort infants born before 32 weeks gestation. Methods: We retrospectively identified gestation who had NT-proBNP levels measured when they were admitted to Neonatal Intensive Care Unit shortly after birth. The BPD was assessed at 36 postmenstrual age. with evaluated. Receiver operator...
Background: Neonatal gastric perforation is a rare but life-threatening issue. The aim of this study was to describe the clinical characteristics and prognosis patients with neonatal identify predictive factors for poor prognosis. Methods: This retrospective cohort treated in tertiary pediatric public hospital between April 2009 October 2020. enrolled were divided into survival non-survival groups. Demographic information, characteristics, laboratory imaging features, outcomes collected from...
Objectives: This study aimed to explore the clinical value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting moderate-to-severe bronchopulmonary dysplasia (BPD)/death, and establish an effective predictive nomogram. Methods: We retrospectively analyzed very low birth weight infants (VLBWs) with gestational age ≤ 32 weeks. The NT-proBNP values were determined on 1st, 3rd, 7th, 14th, 21st, 28th days after birth. correlation between level BPD/death was evaluated. Receiver...
Background Hypothermia is a common problem that associated with increased mortality and morbidity among preterm infants, especially in China. The objective of this study was to evaluate the efficacy targeted quality improvement (QI) project applied hypothermia prevention measures for very-low-birth-weight (VLBW) infants three tertiary neonatal intensive care units (NICUs) Problem Between January 2018 December 2018, we conducted prospective analysis found incidence AH 88.2% VLBW infants....
Pneumonic-type invasive mucinous adenocarcinoma (IMA) was often misdiagnosed as pneumonia in clinic. However, the treatment of these two diseases is different.A total 341 patients with pneumonic-type IMA (n = 134) and infectious 207) were retrospectively enrolled from January 2017 to 2022 at six centers. Detailed clinical CT imaging characteristics groups analyzed between compared by χ2 test Student's t test. The multivariate logistic regression analysis performed identify independent...
Extreme ambient temperature has been linked to decline in males' semen quality. Although the temperature-semen quality association examined certain cities of South China, how effect size extreme may lag over critical windows spermatogenesis and whether strength vary North China have yet adequately explored.
This study quantified the burden of hypoxic respiratory failure (HRF)/persistent pulmonary hypertension newborn (PPHN) in preterm and term/near-term infants (T/NTs) by examining health care resource utilization (HRU) charges United States.Preterms T/NTs (≤34 >34 weeks gestation, respectively) having HRF/PPHN, with/without meconium aspiration inpatient setting from January 1, 2011-October 31, 2015 were identified Vizient database (first hospitalization=index hospitalization). Comorbidities,...