A5100662215- Computational Drug Discovery Methods
- Synthesis of Indole Derivatives
- Advanced Radiotherapy Techniques
- Infant Development and Preterm Care
- Multicomponent Synthesis of Heterocycles
- Hormonal Regulation and Hypertension
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Neonatal Respiratory Health Research
- Pharmacogenetics and Drug Metabolism
- Mesoporous Materials and Catalysis
- Medical Imaging and Analysis
- Head and Neck Cancer Studies
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Endometrial and Cervical Cancer Treatments
- Click Chemistry and Applications
- Ultrasound Imaging and Elastography
- Protein Structure and Dynamics
- Organometallic Compounds Synthesis and Characterization
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Radiation Dose and Imaging
Shandong First Medical University
2020-2022
Springhouse
2022
Janssen (United States)
2022
Tumor Hospital of Guangxi Medical University
2014-2020
Shandong Provincial Hospital
2020
Shandong University
2020
Liaocheng People's Hospital
2020
Allergan (United States)
2019
Guangxi Medical University
2017
Activated factor XI (FXIa) inhibitors are promising novel anticoagulants with low bleeding risk compared current anticoagulants. The discovery of potent FXIa good oral bioavailability has been challenging. Herein, we describe our effort, utilizing nonclassical interactions to improve potency, cellular permeability, and by enhancing the binding while reducing polar atoms. Beginning literature-inspired pyridine N-oxide-based inhibitor 1, imidazole linker was first replaced a pyrazole moiety...
Background Hypothermia is a common problem that associated with increased mortality and morbidity among preterm infants, especially in China. The objective of this study was to evaluate the efficacy targeted quality improvement (QI) project applied hypothermia prevention measures for very-low-birth-weight (VLBW) infants three tertiary neonatal intensive care units (NICUs) Problem Between January 2018 December 2018, we conducted prospective analysis found incidence AH 88.2% VLBW infants....
It is well-known that the structure-based design approach has had a measurable impact on drug discovery process in identifying novel and efficacious therapeutic agents for variety of disease targets. The de novo inherent potential to generate molecules best fit into protein binding site when compared all computational methods applied design. In its initial attempts, this did not achieve much success due technical hurdles. More recently, algorithmic advancements methodologies clever...
With the continuous progress in ultralarge virtual libraries which are readily accessible, it is of great interest to explore this large chemical space for hit identification and lead optimization using reliable structure-based approaches. In work, a novel growth-based screening protocol has been designed implemented design platform CONTOUR. The was used screen ZINC database silico optimize hits discover 11β-HSD1 inhibitors. contrast molecular docking, process makes significant improvements...
Many studies have reported that inverse planning by simulated annealing (IPSA) can improve the quality of brachytherapy plans, and we wanted to examine whether IPSA could cervical cancer plans giving D90 < 6 Gy (with 7 per fraction) at our institution. Various involving tandem ovoid applicators were developed for 30 consecutive patients on basis computed tomography: IPSA1, with a constraint maximum dose in target volume; IPSA1-0, identical IPSA1 but without dwell-time deviation constraint;...
BACKGROUND:We used echo-tracking (ET) technique to observe short-term dynamic changes of the carotid artery in nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiation therapy (IMRT). MATERIAL AND METHODS:Sixty-one NPC received IMRT. In irradiation group, was examined by ultrasonography before radiotherapy, at 2, 4, and 6 weeks start 3 months end radiotherapy. control radiotherapy group. RESULTS:During for 61 patients, maximum dose on 65.14±4.35 Gy, average 57.46±4.12 50%...
Abstract Background: Hypothermia is still a common problem and associated with increased mortality morbidity in preterm infants, especially China. The objective of this study was to evaluate the efficacy targeted quality improvement (QI) project hypothermia preventive measures very low-birth weight (VLBW) infants 3 tertiary neonatal intensive care unit (NICU) Methods: Based on literature, our preliminary findings needs each unit, team decided focus efforts equipment (transport incubator,...
Abstract BackgroundOvercrowding, abuse of antibiotics and increase antimicrobial resistance negatively affect neonatal survival rates in developing countries. We aimed to define pathogens their (AMR) early-onset sepsis (EOS), hospital-acquired late-onset (HALOS) community-acquired (CALOS) 25 intensive care units (NICUs) China.Study designThis retrospective descriptive study included AMR from all neonates with bloodstream infections (BSIs) admitted tertiary hospitals China January 1, 2017,...
Objective To evaluate the effect of carbon fiber couch on dose distribution radiotherapy planning and verification pass rate.Methods Establishing treatment model in Pinnacle8.0m Treatment Planning system (TPS),and then this was used to correct calculations oblique fields plans 10 cases nasopharyngeal carcinoma,10 breast cancer lung whole plans.Then these were measured by three-dimensional equipment Delta4 confirm improvement extent Gamma rate after considering couch.Results For majority...
Objective To make a dosimetric comparison of different craniospinal irradiation (CSI) plans and to explore the impacts setup error on target dose distribution.Methods Five radiotherapy [2D-conventional,single filed 3D(3D-1),three fields 3D(3D-3),IM RT electron]were made from 9 patients' CT images,who received CSI July 2011 October 2012.The coverage (V95),hot spot (V107),maximum (Dmax),conformal index (CI) homogeneity (HI) each plan were compared.The volume thyroid,heart,lungs,small...
The substituent effect on the UV and IR spectral properties of indolylchalcones has been studied. A linear Correlation between constants σand λmax in vc-oin observed.