A5100363375- Liver Disease Diagnosis and Treatment
- Healthcare during COVID-19 Pandemic
- Insect Pest Control Strategies
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Science and Education Research
- Maternal and Neonatal Healthcare
- Hepatitis C virus research
- Land Use and Ecosystem Services
- Rural Development and Agriculture
- Pancreatic function and diabetes
- Child Nutrition and Water Access
- COVID-19 Impact on Reproduction
- Mosquito-borne diseases and control
- Urban Transport and Accessibility
- Obesity, Physical Activity, Diet
- Public Health in Brazil
- Geography and Environmental Studies
- Health Education and Validation
- Parasites and Host Interactions
- Lymphoma Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Vector-borne infectious diseases
- Global Maternal and Child Health
- Diabetes Treatment and Management
Centra Health
2024
Universidade do Porto
2023
Centro Hospitalar do Porto
2023
Universidade do Estado de Minas Gerais
2015-2022
Mount Sinai Health System
2022
Icahn School of Medicine at Mount Sinai
2022
EsSALUD
2022
Janssen (United States)
2013-2022
Springhouse
2013-2022
ORCID
2022
The purpose of the study was to assess incidence alcohol and amphetamine use among long-distance truck drivers. There were studied 91 drivers at gas station in Passos, Southeastern Brazil, November 2005. Data collected using a questionnaire comprising 19 multiple choice questions. Descriptive statistics, Chi-square test Cramér's correlation coefficient used for data analysis. results indicated that 66% amphetamines during their travels, mainly stations along highways (54%). Alcohol consumed...
Canagliflozin is an oral antihyperglycemic agent used for the treatment of type 2 diabetes mellitus. It blocks reabsorption glucose in proximal renal tubule by inhibiting sodium-glucose cotransporter 2. This article describes vivo biotransformation and disposition canagliflozin after a single dose [<sup>14</sup>C]canagliflozin to intact bile duct-cannulated (BDC) mice rats dogs humans. Fecal excretion was primary route elimination drug-derived radioactivity both animals In BDC rats, most...
The aim of this study is to evaluate the relationship between latency diagnosis (LD) and time completion chemotherapy (TCC) with clinical outcomes in children osteosarcoma.We performed a retrospective analysis all patients who received treatment for osteosarcoma two tertiary centers Peru from 2008 2015. All causes delayed LD or TCC were evaluated. Overall survival (OS) event-free-survival (EFS) estimated compared according LD, TCC, established prognostic factors.One hundred thirteen included...
Inflammatory diseases such as rheumatoid arthritis and psoriasis are characterized by increases in circulating cytokines, which play an important role modulation of the disease state. Several marketed bio-therapeutics target cytokines act effective treatment strategies. Previous in-vitro in-vivo studies have suggested that may both direct indirect effects on drug metabolizing enzyme levels liver. Few models to evaluate risk potential interactions might be mediated changes cytokine levels. In...
The humanized liver mouse model is being exploited increasingly for human drug metabolism studies. However, its stability, intercommunication between hepatocytes and nonparenchymal cells in murine intestine, changes extrahepatic transporter enzyme expressions have not been investigated. We examined these issues FRGN [fumarylacetoacetate hydrolase (<i>Fah−/−</i>), recombination activating gene 2 <i>(Rag2−/−)</i>, interleukin receptor subunit gamma <i>(IL-2rg −/−)</i> triple knockout] on...
Activated factor XI (FXIa) inhibitors are promising novel anticoagulants with low bleeding risk compared current anticoagulants. The discovery of potent FXIa good oral bioavailability has been challenging. Herein, we describe our effort, utilizing nonclassical interactions to improve potency, cellular permeability, and by enhancing the binding while reducing polar atoms. Beginning literature-inspired pyridine N-oxide-based inhibitor 1, imidazole linker was first replaced a pyrazole moiety...
Introdução: A esquistossomose mansônica é uma doença negligenciada no Brasil, logo, relacionada à pobreza e ausência de condições sanitárias. Ocorre na região litorânea do nordeste se interioriza a partir estado da Bahia, chegando Minas Gerais. Objetivo: Agrupar, por meio análise componentes principais, as principais variáveis relacionadas em fatores que possam explicar variância dos dados. Métodos: Foram avaliadas notificações entre os anos 2007 2014, considerando média 100 mil habitantes....
GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release enteroendocrine of the small intestine. full agonists exhibit superior glucose lowering compared to partial in preclinical species due increased GLP-1 secretion, with added benefit promoting weight loss. In our search for potent agonists, we discovered superagonist displayed excellent vitro potency efficacy Gαs-mediated signaling...
Azadirachta indica, the so-called Neem or Nim, is well-known for its biological activities in many countries. The present study aimed at investigating antifeedant properties of hydroalcoholic extract obtained from leaves on Zabrotes fasciatus (Coleoptera: Bruchidae), an insect pest that commonly feeds common bean (Phaseolus vulgaris) during seed storage. We observed displayed significant activity when it was added to diet via Phaseolus vulgaris seeds. Additionally, inhibitory effects this...
Usually occurring entirely intrasellarly or extending suprasellarly (intra-suprasellar), Rathke’s cleft cysts (RCCs) can present with an intrasphenoidal location. Extrasellar positions are rare. To date, only seven patients RCC have been reported in the literature. Despite rarity of condition and lack pathognomonic radiological features, preoperative diagnosis remains challenging. A trans-sphenoidal approach be adopted to treat this type cyst, which has great clinical relevance. Awareness...
Chimeric mouse liver models are useful in vivo tools for human drug metabolism studies; however, integrity and the microcirculation remain largely uninvestigated. Hence, we conducted perfusion studies to examine these attributes FRGN [<i>Fah(−/−)</i>, <i>Rag2(−/−)</i>, <i>Il2rg(−/−),</i> NOD strain] livers (control) chimeric repopulated with (mFRGN) or (hFRGN) hepatocytes. In single-pass (2.5 ml/min), outflow dilution profiles of noneliminated reference indicators (<sup>51</sup>Cr-RBC,...
In this study, we examined the expression of hepatitis C virus (HCV) components in hepatocytes and peripheral blood mononuclear cells (PBMC) from patients positive for anti-HCV antibodies negative serum HCV-RNA. The samples obtained 25 randomly selected (13 showed no histological evidences chronic had normal ALAT GGTP levels) were studied by situ Hybridization Immunofluorescence assays. findings show that HCV-RNA both polarity was carried more than 80% cases. proportion expressing strand...
An intensive search for predictive markers of individual radiation response apparently normal tissues in cancer patients is progress at the genetic and epigenetic levels. However, relative impact variability these levels not clear. Experimental results obtained inbred rodents, which have significantly reduced heterogeneity to a population human patients, may help clarify this issue. We investigated paired-organ mouse system strain mice evaluate intermouse tissue response, singled out from...
to develop an educational intervention through a game that addresses aspects related adolescent motherhood and child care.this is action research based on diagnosis, apprehension stages.the situational diagnosis was literature review care. In the stage, game's first version elaborated. third stage constituted by apprehension, submitted assessment of interdisciplinary experts. Suggestions experts were adopted had its second version.the in present study appears care technology adds knowledge...
Cardiac sarcoidosis (CS) overlaps in clinical presentation with arrhythmogenic right ventricular cardiomyopathy and shares phenotypic classification, including the presence of epsilon waves. The conduction disease is seen exclusively CS, as an important difference. We present a case tachycardia waves due to without disease. (Level Difficulty: Intermediate.)
Resumo A mortalidade infantil é problema de saúde pública e importante indicador, considerando-se que parte dessas mortes ocorre por causas evitáveis. O objetivo deste estudo foi identificar aglomerados espaciais óbitos crianças entre 0 4 anos, evitáveis variáveis epidemiológicas em Minas Gerais, 2011 2015, o possibilitaria melhorar planejamento dos serviços do estado. Em ordem decrescente, as intervenções mais contribuíram para reduzir a incidência desses foram atenção à mulher na gestação...
The metabolic fate of adrenocorticotropic hormone (ACTH) fragment 4–10 (4–10) was evaluated following incorporation a nonradioactive <sup>127</sup>I-tag and with selective detection I<sup>+</sup> at <i>m/z</i> 127 by inductively coupled plasma mass spectrometry (ICP-MS). <sup>127</sup>I has all the advantages radioactive <sup>125</sup>I as metabolite tracer and, together its in femtogram range, led to successful profiling <sup>127</sup>I-ACTH vitro. observed stability this peptide tissue...
Objetivo: Caracterizar o perfil epidemiológico dos portadores de Hepatite C cadastrados em um Serviço Referência Regional para Hepatites Virais no interior do Estado Minas Gerais. Método: Estudo descritivo, documental, com análise quantitativa. A pesquisa foi aprovada pelo Comitê Ética Pesquisa, parecer n° 560.257. Foram analisadas 128 fichas notificação por hepatites virais período 2007 a julho 2014. Resultados: 66% são sexo masculino faixa etária entre 50 59 anos. 24,21% possui ensino...
Analysis of Hepatitis C Virus (HCV)-infected hepatocytes at the cellular level may contribute to elucidate mechanisms HCV pathogenesis. In this work, presence components and pathological reactions in apoptotic from chronic HCV-infected patients were studied by electron microscopy confocal microscopy. Eight samples liver biopsies with hepatitis laser scanning microscopy, Transmission Electron Microscopy (TEM) Immunoelectron (IEM). Data provide evidence for apoptosis during infection....
Introduction : Proactive esophageal cooling has been FDA cleared to reduce the likelihood of ablation-related injury resulting from radiofrequency (RF) cardiac ablation procedures. Data suggest that procedure times for RF pulmonary vein isolation (PVI) also decrease when proactive is employed instead luminal temperature (LET) monitoring. Reduced may allow increased electrophysiology (EP) lab throughput. We aimed quantify change in EP throughput PVI cases after introduction cooling. Methods...