A5002412695- Atomic and Subatomic Physics Research
- Cerebral Palsy and Movement Disorders
- Forensic Toxicology and Drug Analysis
- Analytical Chemistry and Chromatography
- Neurotransmitter Receptor Influence on Behavior
- Muscle activation and electromyography studies
- Non-Invasive Vital Sign Monitoring
- Psychedelics and Drug Studies
- Spinal Cord Injury Research
- Shoulder Injury and Treatment
- Heart Rate Variability and Autonomic Control
- Virtual Reality Applications and Impacts
- Advanced MRI Techniques and Applications
- Nerve Injury and Rehabilitation
- Blood Pressure and Hypertension Studies
- Infant Development and Preterm Care
- Stroke Rehabilitation and Recovery
- Shoulder and Clavicle Injuries
- Cardiac electrophysiology and arrhythmias
- Mass Spectrometry Techniques and Applications
- Advanced Optical Imaging Technologies
- Balance, Gait, and Falls Prevention
- Botulinum Toxin and Related Neurological Disorders
- Cardiac Imaging and Diagnostics
- Automotive and Human Injury Biomechanics
Korea Research Institute of Standards and Science
2011-2025
Korea University of Science and Technology
2020-2025
Janssen (United States)
2015-2024
Johnson & Johnson (United States)
2024
Yeouido St. Mary's Hospital
2020
Catholic University of Korea
2020
Springhouse
2017-2020
Hallym Polytechnic University
2019
Janssen (Belgium)
2014-2018
Seoul National University
2014
PURPOSE: To determine serial changes in hepatocellular carcinomas (HCCs) treated with percutaneous radio-frequency (RF) ablation at long-term follow-up multiphase helical computed tomography (CT). MATERIALS AND METHODS: There were 43 nodular HCCs 40 patients CT performed not less than 12 months after RF ablation. All underwent immediately, 1 month, and then every 3 The attenuation, enhancement pattern, shape, other findings, volume of the ablated lesions analyzed CT. RESULTS: Thirty-eight...
Four biotransformation pathways of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat have been identified: N-demethylation, O-dealkylation, deamination, and conjugation (O-methylation, O-glucuronidation, and/or O-sulfation). The specific MDMA metabolites that identified are 3-hydroxy-4-methoxymethamphetamine, 4-hydroxy-3-methoxymethamphetamine, 3,4-dihydroxymethamphetamine, 4-hydroxy-3-methoxyamphetamine, 3,4-(methylenedioxy)amphetamine (MDA), (4-hydroxy-3-methoxyphenyl)acetone,...
Aims: To isolate endophytic fungi from vegetable plants and examine their in vivo anti‐oomycete activity against Phytophthora infestans tomato plants. Methods Results: Endophytic were isolated surface‐sterilized plant tissues was measured by assay using seedlings. showing potent identified morphological characteristics nuclear ribosomal ITS1‐5.8S‐ITS2 sequence analysis. A total of 152 isolates obtained 66 healthy tissue samples cucumber, red pepper, tomato, pumpkin Chinese cabbage the...
Objective. This study was designed to characterize the rudimentary residual lower-limb motor control that can exist in clinically paralyzed spinal-cord-injured individuals. Methods. Sixty-seven subjects were studied using surface electromyography recorded from muscles of lower limbs and analyzed for responses a rigidly administered protocol reinforcement maneuvers, voluntary movement attempts, vibration, or ability volitionally suppress withdrawal evoked by plantar stimulation. Results....
Shoulder tightness may cause altered kinematics and lead to development of subacromial impingement, tendinitis, degenerative changes. In this investigation, the humeral head translations, scapular kinematics, scapulohumeral rhythm were determined with a three-dimensional electromagnetic tracking device during arm elevations in six subjects anterior shoulder posterior study effects anterior/posterior on kinematics. Subjects showed lower slopes curves glenohumeral elevation plotted against...
Canagliflozin is an oral antihyperglycemic agent used for the treatment of type 2 diabetes mellitus. It blocks reabsorption glucose in proximal renal tubule by inhibiting sodium-glucose cotransporter 2. This article describes vivo biotransformation and disposition canagliflozin after a single dose [<sup>14</sup>C]canagliflozin to intact bile duct-cannulated (BDC) mice rats dogs humans. Fecal excretion was primary route elimination drug-derived radioactivity both animals In BDC rats, most...
No reliable quantitative and objective measurement method for virtual reality (VR) sickness has been firmly established to date. Electroencephalography (EEG) may be a strong candidate evaluate VR objectively. However, no test-retest evaluation made using EEG. To recruit sickness-sensitive participants, we tested 858 participants (age = 20′s–50′s) the Motion Sickness Susceptibility Questionnaire (MSSQ). Among them, recruited 21 males (average age 25.0) who obtained 75th percentile of scores...
With the increasing use of virtual reality (VR) devices, interest in reducing their negative effects, such as VR sickness, is also increasing. This study used electroencephalography (EEG) to investigate participants' sickness recovery time after watching a video. We tested 40 participants advance using motion susceptibility questionnaire (MSSQ). classified into two groups (sensitive group/non-sensitive group) depending on MSSQ scores. simulator (SSQ) and EEG evaluate sickness. The SSQ score...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantification of LSD and N-demethyl-LSD in urine by gas chromatography/resonance electron capture ionization mass spectrometryHeng Keang. Lim, David. Andrenyak, Paula. Francom, Rodger L. Foltz, Reese T. JonesCite this: Anal. Chem. 1988, 60, 14, 1420–1425Publication Date (Print):July 15, 1988Publication History Published online1 May 2002Published inissue 15 July...
Virtual reality (VR) is an immersive technology capable of simulating alternate realities, however, it often leads to cybersickness, causing discomfort for users. We conducted experiment using a group 30 participants (aged 25 ± 2.1 years) see the alpha and delta wave changes three conditions: Blank, Video, Video Pause, with electroencephalography (EEG) recordings. The experiments were repeated times (Trial 1, Trial 2, 3). results showed significant increase in power compared Blank (p <...
Journal Article Determination of LSD in Urine by Capillary Column Gas Chromatography and Electron Impact Mass Spectrometry Get access Paula Francom, Francom Center for Human Toxicology, University Utah, Salt Lake City, Utah 84112 Search other works this author on: Oxford Academic PubMed Google Scholar David Andrenyak, Andrenyak Heng-Keang Lim, Lim Robert R. Bridges, Bridges Rodger L. Foltz, Foltz * *Author to whom correspondence should be addressed. Reese T. Jones Langley Porter...
The effects of 3,4-dihydroxymethamphetamine (DHM) and 2,4,5-trihydroxymethamphetamine (THM) on central serotonergic dopaminergic systems were investigated to determine if these metabolites share the neurochemical properties 3,4-methylenedioxymethamphetamine. THM (50-200 micrograms) or DHM (135 was administered i.c.v. rats; 5 days later, cortical, striatal hippocampal tryptophan hydroxylase (TPH) activity decreased by in a dose-dependent manner, whereas without effect brain structures....
Abstract Background One of the most common side effects anti‐cancer therapies is treatment‐induced skin changes, referred to as dermatological toxicities. These toxicities are noteworthy since they have a negative association with quality life (QoL). Objectives To evaluate impact on QoL cancer patients and identify relationship between disease‐related characteristics changes in protective behaviours following therapy. Methods Cancer ( n = 80: stage II–IV) longitudinal prospective study...
Aims Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential canagliflozin to cause clinical drug–drug interactions (DDIs) was assessed. Methods DDI investigated using vitro test systems containing metabolizing enzymes or transporters. Basic predictive approaches were applied determine vivo . A physiologically‐based pharmacokinetic (PBPK) model developed and simulations performed likelihood cytochrome P450 (CYP) inhibition by canagliflozin....
We evaluated the interrater and intrarater reliabilities of Korean version Alberta Infant Motor Scale (K-AIMS).For reliability test, six raters participated in K-AIMS evaluation using video clips 70 infants (aged between 0 18 months). One rater an test. Among infants, 46 were born preterm 24 full term. A total 58 AIMS items for supine, prone, sitting, standing positions. analysis was conducted ICC Fleiss' kappa.The highest kappa found 4-7 months group sitting (K = 0.701-1.000) 0.721-1.000),...
The high prevalence of shoulder-related dysfunction has focused increased attention on functional activity assessment. This study (1) tested the reliability three-dimensional shoulder complex movements during four tasks representing different levels task difficulty, (2) characterized tasks, and (3) examined relationships between age movements. Twenty-five asymptomatic subjects, all veterans aged 30-82, performed tasks. Good within-session was found (movement pattern: similarity index = 0.81...
Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes the progression of advanced prostate cancer. One mechanism is point mutations in ligand binding domain that can transform antagonists into agonists. The F877L mutation, identified patients treated with enzalutamide or apalutamide, confers both apalutamide. Compound 4 (JNJ-pan-AR) was as a pan-AR antagonist potent activity against wild-type clinically relevant...