A5100756123- Ovarian function and disorders
- Lipoproteins and Cardiovascular Health
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Traditional Chinese Medicine Studies
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microbial Natural Products and Biosynthesis
- Healthcare and Venom Research
- Heart Rate Variability and Autonomic Control
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Assisted Reproductive Technology and Twin Pregnancy
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Gynecological conditions and treatments
- 14-3-3 protein interactions
- Growth Hormone and Insulin-like Growth Factors
- Sodium Intake and Health
- Pregnancy-related medical research
- Urologic and reproductive health conditions
- Genital Health and Disease
- Menopause: Health Impacts and Treatments
- Endometrial and Cervical Cancer Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2023-2025
Huazhong University of Science and Technology
2020-2023
Union Hospital
2001-2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2022
Second Affiliated Hospital of Nanjing Medical University
2022
Wuhan Union Hospital
2012-2020
Academy of Medical Sciences
2019
Fu Wai Hospital
2017-2019
State Key Laboratory of Cardiovascular Disease
2019
Dyslipidemia is one of the most important factors for coronary artery disease (CAD). Atherogenic index plasma (AIP) a novel indicator involved in dyslipidemia. However, relation between AIP and CAD postmenopausal women remains unclear. We hypotheses that strong predictive women. A propensity score matching case-control study including 348 cases controls was conducted present study. Compared with controls, patients had higher levels total cholesterol (TC), triglyceride (TG), low-density...
Oxidative stress and sustained sympathetic over-activity contribute to the pathogenesis of hypertension. Catheter-based renal denervation has been used as a strategy for treatment resistant hypertension, which interrupts both afferent efferent fibers. However, it is unknown whether selective (RAD) may play beneficial roles in attenuating oxidative activity This study investigated impact RAD on hypertension vascular remodeling. Nine-week-old normotensive Wistar-Kyoto rats (WKY) spontaneously...
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder, its pathogenesis still under debate. Trimethylamine-N-oxide (TMAO) a small, organic compound generated by the gut microbiome with hypothesized relation to insulin resistance (IR) low-grade inflammation in PCOS. By comparing plasma TMAO levels non-PCOS participants PCOS patients without hyperandrogenism (HA), we aimed determine whether correlate HA analyze their relationship IR.A total of 27 23 were enrolled this study...
Abstract We investigated simultaneously traditional and novel lipid indices, alone or in combination, predicting coronary severity assessed by Gensini score (GS) 1605 non-lipid-lowering-drug-treated patients undergoing angiography. Firstly, levels of triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), non high (non-HDL-C), apolipoprotein (apo) B, (a) [Lp(a)], proprotein convertase subtilisin/kexin type 9 (PCSK9), apoC3, small dense LDL (sdLDL) large HDL were...
The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. association between polymorphisms of beta‐adrenergic receptor ( β‐AR ) genes and in hypertensive patients was investigated. Two β 1 ‐AR A rg389/ G ly) 2 rg16/ were genotyped untreated normotensive patients. In with hypertension, the frequency ly389 homozygote significantly higher hypotension OH P <.0001) lower hypertension OHT =.002) as compared normotension ONT even after B onferroni...
Abstract Background Acylation stimulating protein (ASP) is an adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes. Previous studies have shown ASP-deficient C3 knockout mice are hyperphagic yet lean, as they display increased oxygen consumption fatty acid oxidation compared to wildtype mice. In the present study, antibodies against ASP (Anti-ASP) human recombinant (rASP) were tested vitro vivo . Continuous administration for 4 weeks via osmotic...
Abstract Several studies have demonstrated increases in acylation stimulating protein (ASP), and precursor C3 obesity, diabetes dyslipidemia, however the nature of regulation is unknown. To evaluate chronic hormonal pharmaceutical mediated changes ASP potential mechanisms, 3T3‐L1 adipocytes were treated with physiological concentrations relevant hormones drugs currently used treatment metabolic diseases for 48 h. Medium production secretion evaluated relation to adipocyte lipid metabolism...
Abstract Background Relapses of epithelial ovarian carcinoma (EOC) have a poor prognosis and are almost always fatal. The aim this study was to evaluate the clinical outcome toxicity intraoperative electron beam radiation therapy (IOERT) in advanced recurrent EOC. Methods Forty-five women with EOC were treated IOERT. Twenty-five patients had primary disease (PD) without distant metastasis at IOERT, 20 an isolated local recurrence (ILR) after surgery. All 45 series underwent optimal...
In the past few years, there has been increasing interest in production and physiological role of acylation-stimulating protein (ASP), identical to C3adesArg, a product alternative complement pathway generated through C3 cleavage. Recent studies (-/-) mice that are ASP deficient have demonstrated for postprandial triglyceride clearance fat storage. The aim present study was establish cell model sensitive ELISA assay evaluation using 3T3-L1 adipocytes. preadipocytes were differentiated into...
Abstract Polycystic ovarian syndrome (PCOS) is a common endocrine disease in adolescents and women of childbearing age, also cause female infertility. In recent years, studies have found that the occurrence PCOS related to changes intestinal flora. Trimethylamine N-oxide (TMAO) an organic compound produced by microorganisms. However, relationship between TMAO remain mostly unexplored. The effects on were assessed vitro vivo. rat model, plasma TMAO, hormone PI3K signaling levels examined....
Usphenethylones A–B (1–2) feature a 2,6,18-trioxa-tetracyclo-[8.8.0.0 3,8 .0 11,16 ]octadecane core and usphenethylone C (3) possesses special 2-phenyl-3,4-dihydro-pyrano[4,3- b ]pyran-5-one scaffold.
A 17-year-old Chinese male was hospitalized exhibiting hyperglycemia and increased serum urea nitrogen creatinine levels in addition to weight loss. The patient treated with gliclazide. 150 cm tall, weighed 35 kg had no family history of diabetes or kidney disease. Physical examination revealed cephalus quadratus, rachitic rosary a visible toe-out gait. Laboratory examinations that the patient's fasting plasma glucose glycosylated hemoglobin were markedly increased, C-peptide level slightly...
Previous studies have suggested that leptin was associated with atherosclerosis and involved in inflammation. Gender differences between inflammatory markers been evaluated less untreated patients stable coronary artery disease (CAD).
Abstract Background: Outcomes in patients with poor ovarian response (POR) have been less favorable and there is a need for improvement. The patient-oriented strategy encompassing individualized oocyte number (POSEIDON) criteria，proposed 2016, are now widely accepted used clinical practice. POSEIDON Group 2 considered as “Unexpected low response”, which challenge clinicians. Currently, multiple reviews retrospectively analysed the ART outcomes hyporesponsive populations of Groups. However,...
Abstract Background Outcomes in patients with poor ovarian response (POR) have been less favorable and there is a need for improvement. The patient-oriented strategy encompassing individualized oocyte number (POSEIDON) criteria, proposed 2016, are now widely accepted used clinical practice. POSEIDON Group 2 considered as “Unexpected low response”, which challenge clinicians. Currently, multiple reviews retrospectively analysed the ART outcomes hyporesponsive populations of Groups. However,...