A5059143123- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Complement system in diseases
- Cannabis and Cannabinoid Research
- Congenital heart defects research
- Pharmacology and Obesity Treatment
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Clinical Nutrition and Gastroenterology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- Macrophage Migration Inhibitory Factor
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immune Response and Inflammation
- Apelin-related biomedical research
Université du Québec à Trois-Rivières
2022-2024
Centre Hospitalier de l’Université de Montréal
2014-2024
German Center for Diabetes Research
2019-2023
Heinrich Heine University Düsseldorf
2019-2023
Deutsches Diabetes-Zentrum e.V.
2019-2023
Helmholtz Zentrum München
2019-2023
Université de Bordeaux
2023
Université de Montréal
2014-2021
Diabetes Research Center
2016
Université Laval
2008-2015
Highlights•Global and hypothalamic Cited1 loss exacerbates diet-induced obesity in female mice•Cited1 is highly enriched estradiol-sensitive melanocortin neurons•Hypothalamic molecularly links the effects of E2 leptin on food intake•Cited1 PomcARC neurons acts as a downstream co-factor for E2-leptin signalingSummaryUntil menopause, women have lower propensity to develop metabolic diseases than men, suggestive protective role sex hormones. Although functional synergy between central actions...
Background:GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and antiinflammatory insulin-sensitizing effects omega-3 (ω-3) polyunsaturated fatty acids. Increasing central ω-3 acid levels has been shown to have both anorectic anxiolytic actions. Despite strong clinical interest GPR120, its role brain largely unknown, thus we sought determine impact GPR120 pharmacological activation on energy balance, food reward, anxiety-like behavior.
Acylation-stimulating protein (C3adesArg/ASP) is an adipokine that acts on its receptor C5L2 to stimulate triglyceride (TG) synthesis in adipose tissue. The present study investigated ASP levels mouse models of obesity and leanness the effect deficiency C3 knockout (C3KO) mice tissue morphology. Plasma wild-type (WT) correlated positively with plasma nonesterified fatty acids (NEFA) ( R = 0.664, P < 0.001) total cholesterol 0.515, 0.001). was increased by 85% obese ob/ob leptin-deficient...
α/β-Hydrolase domain 6 (ABHD6) is a monoacylglycerol hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Although complete or peripheral ABHD6 loss of function protective against diet-induced obesity and insulin resistance, role in central control energy balance unknown. Using viral-mediated knockout approach, targeted measures, pharmacology, we discovered mice lacking from neurons ventromedial hypothalamus (VMHKO) have higher VMH 2-AG levels conditions recruitment...
ASP-deficient mice (C3 KO) have delayed postprandial TG clearance, are hyperphagic, and display increased energy expenditure. Markers of carbohydrate fatty acid metabolism in the skeletal muscle heart were examined to evaluate mechanism. On a high-fat diet, compared with wild-type mice, C3 KO expenditure, decreased RQ, lower ex vivo glucose oxidation (-39%, P = 0.018), higher (+68%, 0.019). They glycogen content (-25%, < 0.05) activities for glycolytic enzymes phosphorylase (-31%, 0.005),...
Abstract Background Postoperative liver dysfunction is the major source of morbidity and mortality in patients undergoing partial hepatectomy. This study tested benefits a metabolic support protocol based on insulin infusion, for reducing following hepatic resection. Methods Consecutive consenting scheduled resection were randomized to receive preoperative dextrose infusion followed by therapy using hyperinsulinaemic normoglycaemic clamp (n = 29) or standard (control group, n 27). Patients...
An exaggerated inflammatory response in patients undergoing major liver resection coupled with poor nutrition diminishes regenerative capacity and increases the risk of postoperative complications.Our objective was to evaluate biological context leading better clinical outcomes hyperinsulinemic-normoglycemic clamp vs. standard care (insulin sliding care).This study a fundamental research analysis patient subset from randomized-controlled at McGill University Health Center.Thirty consenting...
Objective To investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage. Design Male wildtype (WT) C5aR knockout (C5aRKO) mice were fed a low (CHOW) or high sucrose diet-induced obesity (DIO) diet for 14 weeks. Body weight food intake measured weekly. Indirect calorimetry, dietary fatload clearance, insulin glucose tolerance tests also evaluated. Liver, muscle adipose tissue mRNA gene expression by RT-PCR. Results At week one 12, C5aRKO DIO had...
Abstract G protein-coupled receptor 120 (GPR120, Ffar4) is a sensor for long-chain fatty acids including omega-3 polyunsaturated (n-3 PUFAs) known beneficial effects on inflammation, metabolism, and mood. GPR120 mediates the anti-inflammatory insulin-sensitizing of n-3 PUFAs in peripheral tissues. The aim this study was to determine impact stimulation microglial reactivity, neuroinflammation sickness- anxiety-like behaviors by acute proinflammatory insults. We found mRNA be enriched both...
Obesity is considered as a systemic chronic low grade inflammation characterized by increased serum pro-inflammatory proteins and accumulation of macrophages within white adipose tissue (WAT) obese patients. C5L2, 7-transmembrane receptor, serves dual function, binding the lipogenic hormone acylation stimulating protein (ASP), C5a, involved in innate immunity.We evaluated impact C5L2 on macrophage infiltration WAT wildtype (Ctl) knock-out (C5L2(-/-)) mice over 6, 12 24 weeks chow diet...
Acylation stimulating protein (ASP) is an adipokine derived from the immune complement system, which stimulates fat storage and typically increased in obesity, type 2 diabetes, cardiovascular disease. Using a diet-induced obesity (DIO) mouse model, acute effects of ASP on energy metabolism inflammatory processes vivo were evaluated. We hypothesized that would specifically exert proinflammatory effects. C57Bl/6 wild-type mice put high-fat-high-sucrose diet for 12 weeks. Mice then subjected to...
Abstract Insufficient dietary intake of essential omega‐3 polyunsaturated fatty acids (N‐3), especially during critical stages development, is well‐associated with negative neurological and metabolic consequences. The increased availability foods rich in saturated fat coincides reduced N‐3 consumption, yet how deficiency perinatal development modulates motivation for palatable food interacts a high‐fat diet to affect body weight emotional states not clear. Pregnant C57Bl6 mice pups were...
Abstract Background Acylation stimulating protein (ASP) is an adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes. Previous studies have shown ASP-deficient C3 knockout mice are hyperphagic yet lean, as they display increased oxygen consumption fatty acid oxidation compared to wildtype mice. In the present study, antibodies against ASP (Anti-ASP) human recombinant (rASP) were tested vitro vivo . Continuous administration for 4 weeks via osmotic...
AbstractHormones secreted from the adipose tissue, termed adipokines, have been extensively studied in past two decades and this work has triggered a paradigm shift. Previously considered to be passive organ exclusively devoted storage, tissue is now seen as major endocrine modulator of energy homeostasis. Acylation-stimulating protein (ASP) one these adipokines it interacts with its receptor C5L2 induce several anabolic effects. Both ASP are also closely linked immune system. However, few...
Obesity significantly increases the risk for anxiety and depression. Our group has recently demonstrated a role nucleus accumbens (NAc) pro-inflammatory nuclear factor kappa-B (NFkB) signaling in development of anxiodepressive-like behaviors by diet-induced obesity male mice. The NAc is brain region involved goal-oriented behavior mood regulation whose functions are critical to hedonic feeding motivation. While incidence depression disorders higher women than men, use female animal models...
Abstract α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting metabolism and body weight. Brain ABHD6 degrades 2-arachidonoylglycerol thereby modulates cannabinoid receptor signaling. However, it’s functional role within mesoaccumbens circuitry that critical for motivated behavior known be significantly modulated by endocannabinoids remained unknown. Using three viral approaches, we show control of the nucleus accumbens neuronal key determinant weight...
α/β-hydrolase domain 6 (ABHD6) is a lipase linked to physiological functions affecting energy metabolism. Brain ABHD6 degrades 2-arachidonoylglycerol and thereby modifies cannabinoid receptor signalling. However, its functional role within mesoaccumbens circuitry critical for motivated behaviour considerably modulated by endocannabinoids was unknown. Using three viral approaches, we show that control of the nucleus accumbens neuronal key determinant body weight reward-directed in male mice....