A5021111772- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease and Transplantation
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Lipid metabolism and disorders
- Aortic Disease and Treatment Approaches
- Systemic Lupus Erythematosus Research
- Pharmaceutical Economics and Policy
- Cardiac and Coronary Surgery Techniques
- Diabetes Treatment and Management
- Hepatitis C virus research
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
Baylor College of Medicine
2025
Gaozhou People's Hospital
2014-2024
Fu Wai Hospital
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
Beijing Chao-Yang Hospital
2020-2023
Capital Medical University
2023
State Key Laboratory of Cardiovascular Disease
2018-2020
Peking Union Medical College Hospital
2019-2020
Wuhan University
2016-2017
Zhongnan Hospital of Wuhan University
2016-2017
Triglyceride glucose (TyG) index is a novel marker for metabolic disorders and recently it has been reported to be associated with cardiovascular disease (CVD) risk in apparently healthy individuals. However, the prognostic value of TyG patients stable coronary artery (CAD) not determined.We conducted nested case-control study among 3,745 CAD. Patients were followed up 11,235 person-years. The events (CVEs) defined as all-cause death, non-fatal myocardial infarction (MI), stroke...
OBJECTIVE The aim of the current study is to determine impact elevated lipoprotein(a) [Lp(a)] on cardiovascular events (CVEs) in stable coronary artery disease (CAD) patients with different glucose metabolism status. RESEARCH DESIGN AND METHODS In this multicenter study, we consecutively enrolled 5,143 from March 2011 February 2015. Patients were categorized according status (diabetes mellitus [DM], pre–diabetes [pre-DM], and normal regulation [NGR]) levels further classified into 12 groups...
Aim: Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value TyG index HGI in patients with type 2 diabetes mellitus (T2DM) stable coronary artery disease (CAD) is not determined.Methods: We conducted a nested case-control study among 1282 T2DM CAD. Patients were followed up for 3846 person-years. A total 160 events (12.5%) identified matched individually on age, gender,...
Whether prediabetes mellitus (Pre-DM) alone or combined with hypertension is an independent risk factor for cardiovascular disease has not been fully clarified. This study aimed to further confirm whether the relation of Pre-DM differs between individuals without hypertension. A total 7121 consecutive patients angina-like chest pain who received coronary angiography were evaluated and 4193 angiography-proven stable, new-onset artery enrolled into study. They divided 3 groups according...
Abstract Background The atherogenicity of remnant cholesterol (RC) has been underlined by recent guidelines, which was linked to coronary artery disease (CAD), especially for patients with diabetes mellitus (DM). This study aimed examine the prognostic value plasma RC in CAD under different glucose metabolism status. Methods Fasting were directly calculated or measured 4331 CAD. Patients followed occurrence major adverse cardiovascular events (MACEs) and categorized according both status...
The vast majority of protein-coding genes in the human genome produce multiple mRNA isoforms through alternative splicing, significantly enhancing complexity transcriptome and proteome. To establish an efficient method for characterizing transcript within tissue samples, we conducted a systematic comparison between single-cell long-read conventional short-read RNA sequencing techniques. approximately 30,000 mouse retina cells was profiled using 1.54 billion Illumina short reads 1.40 Oxford...
Abstract Background Elevation in small dense low-density lipoprotein (sdLDL) is common patients with diabetes mellitus (DM), which has already been reported to be associated incidence of coronary artery disease (CAD). The aim the present study was investigate prognostic value plasma sdLDL level stable CAD and DM. Methods A total 4148 consecutive were prospectively enrolled into followed up for major cardiovascular events (MACEs) 8.5 years. Plasma measured each patient by a direct method...
Background Although several studies have indicated that lipoprotein(a) is a useful prognostic predictor for patients following percutaneous coronary intervention (PCI), previous observations somewhat been limited by either small sample size or short-term follow-up. Hence, this study aimed to evaluate the impact of on long-term outcomes in large cohort stable artery disease after PCI. Methods and Results In multicenter prospective study, we consecutively enrolled 4078 undergoing PCI from...
Whether lipoprotein(a) (Lp(a)) is a predictor for recurrent cardiovascular events (RCVEs) in patients with coronary artery disease (CAD) has not been established. This study, hence, aimed to examine the potential impact of Lp(a) on RCVEs real-world, large cohort first event (CVE).In this multicentre, prospective 7562 angiography-diagnosed CAD who had experienced CVE were consecutively enrolled. concentrations all subjects measured at admission and participants categorised according tertiles....
Abstract Background Whether plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels is a predictor for cardiovascular outcomes has currently been controversial. No data available regarding the relation of PCSK9 to metabolic markers (CVMMs) and major adverse events (MACEs) in stable coronary artery disease (CAD) patients with diabetes or without diabetes. Methods A total 1225 untreated CAD were consecutively enrolled their baseline determined by ELISA. Patients divided into high...
Abstract Background Merging studies have reported the association of lipoprotein(a) [Lp(a)] with poor outcomes coronary artery disease (CAD) in patients type 2 diabetes mellitus (T2DM). However, prognostic importance Lp(a) for recurrent cardiovascular events (CVEs) is currently undetermined T2DM and prior CVEs. Methods From April 2011 to March 2017, we consecutively recruited 2284 Patients were categorized into low, medium, high groups by levels followed up CVEs, including nonfatal acute...
Background Previous studies have suggested a strong association of liver fibrosis scores (LFSs) with cardiovascular outcomes in patients different diseases. Nonetheless, it is basically blank regarding the prognostic significance LFSs following percutaneous coronary intervention (PCI). This study sought to examine potential role predicting long-term large cohort stable artery disease after elective PCI. Methods and Results In this multicenter, prospective study, we consecutively enrolled...
The prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with coronary artery disease (CAD) different glucose status has not been established. This study sought to evaluate the significance NT-proBNP predicting major adverse cardiovascular events (MACEs) chronic syndrome (CCS) and normal left-ventricular systolic function (LVSF) according status, especially those abnormal metabolism.A total 8062 CCS LVSF were consecutively enrolled this prospective study....
Obtaining intact cylindrical cores from soft, weathered rock is frequently challenging, making the point load test a preferred technique for quickly determining strength. This study critically evaluates two widely used strength calculations—the loading-span and equivalent-diameter methods—and presents an alternative “equivalent area method” founded on ratio between actual failure cross section minimum section. Irregular phyllite specimens spanning three levels of weathering (heavily,...
Patients with monogenic familial hypercholesterolemia (FH) have high risk for coronary artery disease (CAD). A recent FH Expert Panel suggested that was underdiagnosed and undertreated which needs early diagnosis. Moreover, the proportion of DNA-confirmed patients hospitalized very early-onset (≤ 35 years) CAD remains uncertain. One hundred five age ≤ years LDL-C ≥ 3.4 mmol/L were tested 9 genes (LDLR, APOB, PCSK9, APOE, STAP1, LIPA, LDLRAP1, ABCG5/8). Dutch Lipid Clinic Network (DLCN) Simon...
TG-rich lipoprotein (TRL)-related biomarkers, including TRL-cholesterol (TRL-C), remnant-like particle-cholesterol (RLP-C), and apoC-III have been associated with atherosclerosis. However, their prognostic values not fully determined, especially in patients previous CAD. This study aimed to examine the associations of TRL-C, RLP-C, incident cardiovascular events (CVEs) setting secondary prevention Plasma total were directly measured. A 4,355 participants angiographically confirmed CAD...
Abstract Background The aim of the present study is to examine effects free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism status. Methods In this study, we consecutively enrolled 5443 from March 2011 May 2015. Patients were categorized according both status [diabetes mellitus (DM), pre-diabetes (Pre-DM), normal glycaemia regulation (NGR)] FFAs levels. All subjects followed up for occurrence...
<h2>Abstract</h2><h3>Background</h3> Severe hypertriglyceridemia (SHTG, TG ≥5·65 mmol/L), a disease, usually resulting from combination of genetic and environmental factors, may increase the risk acute pancreatitis (AP). However, previous analysis has been limited by lacking related observation gene to AP. <h3>Methods</h3> The expanding sequencing including 15 TG-related genes (LPL, LMF1, APOC2, GPIHBP1, GCKR, ANGPTL3, APOB, APOA1-A4-C3-A5, TRIB1, CETP, APOE, LIPI) was performed within 103...