A5101682337- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- T-cell and Retrovirus Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Neutropenia and Cancer Infections
- Cancer Research and Treatments
- TGF-β signaling in diseases
- Viral-associated cancers and disorders
- Cancer therapeutics and mechanisms
- Colorectal and Anal Carcinomas
- Nutrition and Health in Aging
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
Luye Pharma (China)
2025
Hangzhou First People's Hospital
2012-2023
Hangzhou Cancer Hospital
2002-2023
Zhejiang University
2021-2023
Zhejiang Chinese Medical University
2018-2020
Nanjing Medical University
2018-2019
Tianjin Medical University
2009-2016
First Hospital of Qinhuangdao
2014
Denosumab (Xgeva®) is a standard treatment for the prevention of skeletal-related events (SREs) in patients with bone metastases (BM). This trial was designed to assess equivalence LY01011 denosumab terms efficacy and safety. Eligible BM from solid tumors were randomized at 1:1 ratio receive 120 mg or subcutaneously every four weeks during 12-week double-blind period, then all enrolled continued until week 53. The primary endpoint natural logarithm change urinary N-terminal crosslinked...
The level of transforming growth factor β1 (TGFβ1) and βII receptor (TGFβRII) was determined immunohistochemically in normal tissues with different severities lesions (basal cell hyperplasia, BCH; dysplasia, DYS; carcinoma situ, CIS; squamous carcinoma, SCC) from surgically resected human esophagi esophageal biopsies symptom-free subjects. samples were an area high cancer incidence northern China (Linzhou, formerly Linxian, nearby county Huixian Henan Province). Peroxidase immunostain (ABC)...
Background Pancreatic cancer has a poor prognosis, and it is traditionally treated with chemotherapy. Fortunately, immunotherapy rapidly changed the landscape of solid tumor treatment, improving survival patients. However, pancreatic non-immunogenic, single agent immunotherapies are unfavorable to its prognosis. Case Presentation Here, we report case stage IV in patient TSC2 SMAD4 mutations when disease progressed after multi-line Next generation sequencing (NGS) confirmed presence...
Gastrointestinal stromal tumors (GISTs) are the most common pathologic type of mesenchymal tumor in digestive tract. Patients with GIST face risk metastasis, postoperative recurrence and imatinib mesylate (IM) resistance. Mitochondrial Tu translation elongation factor (TUFM) is highly expressed GISTs, associated oncogenesis, progression prognosis. There evidence that TUFM involved invasion metastasis. However, effect on GIST‑T1 cells IM‑resistant GIST‑IR cell line remains unclear. The...
e21508 Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal which express KIT in gastrointestinal tract or abdominal cavity and appear to be the most common neoplasm of tract. The majority GISTs known have gain-of-function mutations PDGFRA.Imatinib currently becomes a model as targeted therapy for locally advanced metastatic GIST. However, patients with GIST may develop resistance imatinib after median almost 24 months’ treatment. aim this study was establish human xenograft...
Objective To explore the clinical significance of plasma D-dimer level before and after chemotherapy in patients with malignant lymphoma.Methods 402 admitted to Tianjin Medical University Cancer Institute Hospital pathologically diagnosed lymphoma were retrospectively analyzed investigate relationship between patients' their clinic pathology.Meanwhile,the association change therapeutic effect was also evaluated.Results The median levels (734.51ng/ml) distinctly higher than that normal...
Objective To explore the clinicopathological features and prognostic factors in patients with primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL). Methods From January 2007 to 2014, 195 PGI-DLBCL initial treatment were enrolled clinical data of them collected. Clinicopathological features, overall survival situation effects therapeutic strategy on prognosis retrospectively analyzed. Kaplan-Meier method was performed for analysis. Log-rank test used univariate analysis...
Abstract Background According to clinical trials, the median survival time of patients with advanced pancreatic cancer does not exceed 1 year. There are great differences in prognosis between different cancer, and their nutritional status may play a role. In our study, we sought explore predictive value body composition weight alteration during chemotherapy. Methods this retrospective 90 from 3 hospitals metastatic or locally unresectable treated chemotherapy were analysed. The changes...
To establish and characterize imatinib-resistant gastrointestinal stromal tumor (GIST) xenografts. Further provided an ideal experimental platform through the GIST xenografts to investigate mechanism of resistance imatinib.Imatinib-resistant cells were injected under skin athymic nude mice animal models human GIST. The molecular histopathologic features also analysed compared with their counterpart cell lines.The xenograft had been established by subcutaneously injection into mice....
The incidence rate is high in Asia country, accounting for 15 %-20 % of Non-Hodgkin lymphoma. Every phynotype has different heterogeneity, therapeutic effect and prognosis are also different. There no standard rigemen T cell lymphoma at present. CHOP like regimen commonly used. But not as good we expected. Clinical research shows that dose intensity regimen, such m-BACOD,ProMACE-CytaBOM, MACOP-B, do exhibit survival advantage compared with regimen. New treatment includes cytotoxic drug,...
Objective To evaluate prognostic significance of c-kit and PDGFR-α gene mutation in extragastrointestinal stromal tumors(EGIST). Methods Paraffin embedded tissue specimens from 23 EGISTs were tested for CD117,CD34 Ki-67 expression by immunohistochemical method.EGIST cases also the presence exons 9,11,13,17 mutations 12,18 mutations.Kaplan-meier survival rate was used to factors. Results Of EGIST,23(100%)were positive CD117,17(74%)were CD34.For labeling index(Ki-67 LI):30%were＜1%,44%were...