A5100655223- Organometallic Compounds Synthesis and Characterization
- Crystal structures of chemical compounds
- Visual perception and processing mechanisms
- Advanced Optical Imaging Technologies
- Photonic and Optical Devices
- Lung Cancer Treatments and Mutations
- Virtual Reality Applications and Impacts
- Ophthalmology and Eye Disorders
- Conducting polymers and applications
- Organometallic Complex Synthesis and Catalysis
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Lung Cancer Research Studies
- Crystallography and molecular interactions
- Aerogels and thermal insulation
- Advanced Fiber Laser Technologies
- Microwave-Assisted Synthesis and Applications
- Advanced Photonic Communication Systems
- Sinusitis and nasal conditions
- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Mesoporous Materials and Catalysis
- Fiber-reinforced polymer composites
Shanghai Institute of Technology
2024-2025
Xinjiang Medical University
2020-2024
Dalian University
2024
Shenzhen Second People's Hospital
2024
Jilin Province Tumor Hospital
2024
Second Affiliated Hospital of Xinjiang Medical University
2023-2024
Shenzhen Bao'an District People's Hospital
2022
Jilin Normal University
2007-2021
Sichuan University
2003-2020
West China Hospital of Sichuan University
2003-2020
J o u r n a l P e -p f patients in the iruplinalkib group (median PFS, 27.7 months [95% CI, crizotinib group; HR, 0.34 [98.02% 0.23-0.52];p<0.0001).The ORR assessed by IRC was 93.0% (95% 87.5-96.6) and 89.3% 83.1-93.7) group.The intracranial 90.9% (10/11, 95% 58.7-99.8) 60.0% (9/15, 32.3-83.7) for with measurable baseline CNS metastases.Incidence of grade 3 or 4 treatment-related adverse events 51.7% 49.7% group.Interpretation: Iruplinalkib demonstrated significantly improved PFS antitumor...
Abstract Background Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR sensitizing mutations and T790M mutation. We report the pooled central nervous system (CNS) efficacy data of furmonertinib in patients with mutated non-small cell lung cancer (NSCLC) from two phase 2 studies. Methods This was pooled, post-hoc analysis studies (NCT03127449 [phase 2a study furmonertinib], NCT03452592 2b...
In this work, four novel halogen-bonded cocrystals of three racetam-family pharmaceutical compounds, named etiracetam, aniracetam and nefiracetam, were prepared using perfluorinated iodobenzenes as halogen bond donors through both mechanochemical and...
Currently, the catalytic selective hydrogenation of nitroarenes to produce aromatic amines is one most important key reactions in many fine chemical processes. In particular, non-noble-metal-catalyzed represents more sustainable Here, we report a new robust and recyclable core-shell nanostructured nickel-iron alloy@nitrogen-containing carbon (NiFe@NC) catalyst beneficial effect alloying Ni with Fe for above reaction. The this synthetic strategy was thermally transforming Ni-Fe layered double...
To address the issues of low accuracy and efficiency in traditional image processing algorithms for steel surface defect detection, a novel detection algorithm based on YOLOv8-TLC is proposed. more accurately detect targets images that are missed due to their large size, an additional scale layer introduced. Meanwhile, Large Selective Kernel (LSK) attention mechanism incorporated deeply explore spatial structural information highly relevant targets, further enhancing model’s feature...
Abstract In this paper, we analyze the visual fatigue of integral imaging three‐dimensional (3D) display by studying accommodation and convergence when viewing 3D images. The theoretical analyses show that there is no inconsistency between distances, which means has fatigue. Experiments are implemented, results finally demonstrate rationality analyses. These can be quite beneficial for researchers to better understand performances promote practical applications display.
9602 Background: Alflutinib (AST2818) is a third generation EGFR-TKI. This phase IIb, multicenter, single arm study (ALSC003, NCT03452592) aimed to assess the efficacyand safety of in patients with EGFR T790M mutated non-small cell lung cancer (NSCLC). Methods: Patients locally advanced or metastatic NSCLC who progressed after first/second-generation EGFR-TKIs therapy primary mutation positive received 80 mg orally once daily. Tumor tissue samples underwent central laboratory testing for...
Crizotinib is a well-known anticancer medicine used for the targeted treatment of nonsmall cell lung cancer. The water solubility crizotinib quite low and restricts its oral bioavailability. In this work, saturated alkyl dicarboxylic acids were selected as salt formers, two salts with malonic acid adipic prepared comprehensively characterized by different analytical techniques. Both exhibited comparable physical chemical stability in contrast to crizotinib. most important point was that...
Crystallization of stoichiometric KAlSi 3 O 8 , RbAlSi and CsAlSi gels (single‐phase multiphasic gels) glasses with without seeding has been investigated by X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometry (EDS). The pure K‐, Rb‐, Cs‐feldspar compositions crystallized mainly to leucite (KAlSi 2 6 ), a Rb analogue (RbAlSi pollucite (CsAlSi respectively. glass also yielded leucite. No feldspar phases in the temperature region studied. crystallization...
Abstract The reaction of triphenyltin(IV) hydroxide with the isophthalic acid and benzoic derivatives, 5‐(1,3‐dioxo‐1,3‐dihydro‐isoindol‐2‐yl)‐isophthalic (H 2 L 1 ) 4‐(1,3‐dioxo‐1,3‐dihydro‐isoindol‐2‐yl)‐benzoic (HL yielded complexes [(SnPh 3 ] ( )L ). All were characterized by elemental analysis FT‐IR NMR H, 13 C, 119 Sn) spectroscopy. Interestingly, supramolecular structures are found to consist 1D molecular chains built up intermolecular C–H ··· O hydrogen bonds. Their thermal...
Abstract Rationale: Epithelial keratitis is a common complication after cataract surgery. Many factors have been attributed to this clinical phenomenon. Patient concerns: An 82-year-old woman without previous herpes simplex (HSK) underwent an uncomplicated clear corneal phacoemulsification procedure in the right eye. In late postoperative period, epithelial developed same Diagnosis: initial diagnosis of HSK was made clinically. The lesion refractory antiviral treatment and had progressed....