A5046732056- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- IL-33, ST2, and ILC Pathways
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Macrophage Migration Inhibitory Factor
- Inflammasome and immune disorders
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Frailty in Older Adults
- Advanced X-ray and CT Imaging
- Biomarkers in Disease Mechanisms
- Immune Response and Inflammation
- Protease and Inhibitor Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
Chinese PLA General Hospital
2015-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Beijing University of Agriculture
2024
Institute of Agricultural Resources and Regional Planning
2024
Chinese Academy of Agricultural Sciences
2024
Chinese People's Liberation Army
2013-2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Nankai University
2024
National Clinical Research
2023
Aging augments endotoxemic cardiac dysfunction, but the mechanism remains unclear. Anti-aging protein Klotho has been found to modulate tissue inflammatory responses. We tested hypothesis that a reduced level in aging heart plays role augmented dysfunction.Endotoxin (0.5 mg/kg, iv) was injected adults (4-6 months) and (18-20 C57BL/6 mice. Recombinant (10 μg/kg, administered group of mice after endotoxin injection. Cardiac function analyzed using microcatheter at 24 48 h administration....
Abstract Recombinant antimicrobial peptide microcin J25 (MccJ25) causes potent activity against enterotoxigenic Escherichia coli (ETEC) in vitro; however, independently of this activity, its role suppressing intestinal inflammation and epithelial barrier injury vivo remains unclear. We investigated the therapeutic effects MccJ25 on dysfunction underlying mechanism, using gentamicin for comparison. In a mouse model inflammation, administration either or after ETEC K88 infection attenuated...
Abstract Background Growth differentiation factor-15 (GDF-15) is a marker of inflammation, oxidative stress and it associated with adverse prognosis in cardiovascular disease. The aim the present cohort study to investigate prognostic value GDF-15 patients coronary artery disease (CAD) during long-term follow up. Methods A total 3641 consecutive CAD were prospectively enrolled into followed up for major events (MACEs) all-cause death 5.3–7.6 years. Plasma was measured clinical data...
Abstract In order to repair critical‐sized bone defects, various polylactic acid‐glycolic acid (PLGA)‐based hybrid scaffolds are successfully developed as substitutes. However, the byproducts of these PLGA‐based known acidify implanted site, inducing tiresome acidic inflammation. Moreover, degradation productions cannot offer an osteo‐friendly microenvironment at matching natural healing. Herein, inspired by atlas bone‐healing process, osteo‐microenvironment stage‐regulative scaffold...
Abstract Background studies comparing different frailty measures in intensive care unit settings are lacking. We aimed to compare the index based on physiological and laboratory tests (FI-Lab), modified (MFI) hospital risk score (HFRS) predict short-term outcomes for critically ill patients. Methods we conducted a secondary analysis of data from Medical Information Mart Intensive Care IV database. Outcomes interest included in-hospital mortality discharge with need nursing care. Results...
Objective: To investigate the effects of sphingosine-1-phosphate (S1P) and its analogue FTY720 on lung injury induced by acute necrotizing pancreatitis in rats. Methods: Acute was retrogradely injection 5% sodium taurocholate biliopancreatic duct Sphingosine-1-phosphate (100 µg/kg) or (1 mg/kg) administered immediately after model induction peritoneal injection. Six hours induction, bronchoalveolar lavage protein concentration, total cell count, polymorphonuclear neutrophil percentage,...
Evidence indicates that aberrantly expressed long non-coding RNAs (lncRNAs) are involved in the development and progression of advanced gastric cancer (AGC). Using RNA sequencing data clinical information obtained from The Cancer Gene Atlas, we combined differential lncRNA expression profiling weighted gene co-expression network analysis to identify key lncRNAs associated with AGC prognosis. susceptibility 19 (CASC19) was top hub among included module most significantly correlated AGC's...
Abstract Background Soluble suppression of tumorigenesis-2 (sST2) is implicated in myocardial overload and has long been recognized as an inflammatory marker related to heart failure acute coronary syndrome, but data on the prognostic value sST2 patients with artery disease (CAD) remain limited. This study sought investigate established CAD its predictive without type 2 diabetes mellitus (T2DM). Methods A total 3641 consecutive were included this prospective cohort study. The primary end...
(18)F-fluorodeoxyglucose positron emission tomography and dynamic contrast-enhanced MRI have been proposed to quantitatively assess plaque inflammation by probing macrophages neovessels, respectively. We examined their correlation study the in vivo relationship between macrophage neovessel activities atherogenesis.Forty-one patients (34 men; aged 65±12 years) with a total of 68 carotid plaques (thickness ≥2 mm on ultrasound; 20 symptomatic) were assessed both tomography/computed within 2...
Growing studies have emerged on adipose‐derived stem cells (ADSCs), which hold the potential for cell‐based therapy in diseased injured hearts. Apart from their differentiation pluripotency, such benefits also result ability of paracrine. The results this study showed that after a 24‐h hypoxia culture, ADSCs secreted amplified quantities hepatocyte growth factor, interleukin‐1, vascular endothelial factor‐A, fibroblast factor‐2, and transforming factor‐ β , all increased statistically...
Background: The anti-programmed cell death 1 (PD-1)/programmed ligand (PD-L1) immunotherapy has been extensively used in patients with non-small lung cancer (NSCLC) which the tumors are negative for oncogenic alterations. However, whether PD-1/PD-L1 blockade therapy could be applicable harboring mutations is largely unknown.
The low-temperature environment significantly inhibits the growth and metabolism of denitrifying bacteria, leading to an excessive concentration ammonia nitrogen total in sewage treatment plants during cold season. In this study, efficient strain heterotrophic nitrification–aerobic denitrification(HN-AD) bacteria named HS2 was isolated screened from industrial a chemical factory Inner Mongolia at 8°C. confirmed be Achromobacter spiritinus, colorless rod-shaped bacterium. When cultured with...
Abstract Aims The utility of growth differentiation factor‐15 (GDF‐15) in predicting long‐term adverse outcomes heart failure (HF) patients is not well established. This study explored the relationship between GDF‐15 levels and HF across various ejection fraction (EF) phenotypes associated with coronary disease (CHD) evaluated added prognostic value incorporating into Meta‐Analysis Global Group Chronic Heart Failure (MAGGIC) risk score‐based model. Methods results single‐centre cohort...
This study aims to assess the characteristics of neointimal hyperplasia after drug-eluting stent (DES) implantation in patients with diabetes mellitus (DM) by optical coherence tomography (OCT).OCT was performed 109 (45 DM and 64 without DM) 1 year DES implantation. Neointimal coverage thickness on luminal side were measured. The classified into three patterns, namely, high signal pattern, low pattern layered according intensity. development in-stent neoatherosclerosis also examined. In...
Abstract Background Abdominal obesity as a predominant comorbidity has played key role in the incidence and worsening of heart failure with preserved ejection fraction (HFpEF), waist-to-height ratio (WHtR) behaves better than waist circumference or body mass index evaluating abdominal obesity. While association between WHtR all-cause death Chinese patients HFpEF remains unclear. Methods Patients stable (N = 2041) who presented to our hospital from January 2008 July 2019 were divided into...
Frailty is a state of decreased resilience when person exposed to an apparently innocuous stressor that associated with numerous adverse outcomes. The aim examine frailty prevalence in China by demographic and investigate the correlation between outcome.