A5043774463- Frailty in Older Adults
- Obstructive Sleep Apnea Research
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Dementia and Cognitive Impairment Research
- Advanced Optical Sensing Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Sleep and related disorders
- Nutritional Studies and Diet
- Health disparities and outcomes
- Cardiovascular Health and Disease Prevention
- Balance, Gait, and Falls Prevention
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hip and Femur Fractures
- Radiopharmaceutical Chemistry and Applications
- Geriatric Care and Nursing Homes
- Voice and Speech Disorders
- Restless Legs Syndrome Research
- Dysphagia Assessment and Management
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
Guangdong Provincial People's Hospital
2022-2025
Guangdong Academy of Medical Sciences
2022-2025
Southern Medical University
2021-2025
Chinese PLA General Hospital
2014-2024
University of Chinese Academy of Sciences
2023-2024
Columbia University
2018-2024
National Marine Life Center
2023-2024
Duke Kunshan University
2024
Hainan General Hospital
2021-2023
Qingdao National Laboratory for Marine Science and Technology
2023
Although resting-state functional magnetic resonance imaging (fMRI) studies have observed dynamically changing brain-wide networks of correlated activity, fMRI's dependence on hemodynamic signals makes results challenging to interpret. Meanwhile, emerging techniques for real-time recording large populations neurons revealed compelling fluctuations in neuronal activity across the brain that are obscured by traditional trial averaging. To reconcile these observations, we use wide-field optical...
Abstract Background Cardiovascular disease (CVD) is closely associated with the triglyceride glucose (TyG) index and its related indicators, particularly combination obesity indices. However, there limited research on relationship between changes in TyG-related indices CVD, as most studies have focused baseline Methods The data for this prospective cohort study were obtained from China Health Retirement Longitudinal Study. exposures cumulative 2012 to 2015. K-means algorithm was used...
The anti-HER receptor antibodies cetuximab, trastuzumab, and pertuzumab are used widely in clinic to treat metastatic cancer. However, activation of the extensive crosstalk among HER receptors as well other RTKs, particularly HER-MET crosstalk, has emerged a likely source drug resistance. In this study, we developed two new types tetra-specific that recognize EGFR, HER2, HER3, VEGF. These antibodies, termed FL518 (four-in-one antibody) CRTB6 (tetra-specific, tetravalent antibody), not only...
Sarcopenia is an age-related geriatric syndrome and associated with numerous adverse outcomes. Although there preponderance of studies on sarcopenia in community setting, few focused the oldest old. We investigated prevalence Chinese community-dwelling old examined socio-demographic lifestyle factors sarcopenia. also association between disability activities daily living (ADL) physical function among
This study aimed to investigate the associations of sarcopenia and its defining components with cognitive function in community-dwelling oldest old (over 80 years old) China.Sarcopenia was diagnosed by 2019 Asian Working Group for Sarcopenia (AWGS) criteria. Cognitive evaluated Montreal Assessment (MoCA). Logistic linear regression models were used explore risk mild impairment (MCI), performance on multiple domains among 428 adults aged older.The overall prevalence 35.5%, 40.34% men 32.14%...
Depression can lead to a wide range of adverse health outcomes, including dementia. However, evidence supporting the relationship between depression and motoric cognitive risk syndrome (MCR), pre-dementia syndrome, remains lacking. This study aimed examine association MCR among community-dwelling Chinese older adults.Data were taken from 2011 2015 waves China Health Retirement Longitudinal Study (CHARLS). was defined by Center for Epidemiological Studies Scale (CES-D) score ≥10. as...
Abstract Background Frailty is a clinically recognizable state of reduced resilience to stressors and increased vulnerability adverse outcomes. The majority studies have focused on the prevalence risk factors frailty, while incidence frailty has not been well documented, especially in less developed regions including China—a country that largest aging population world. We investigated among non-frail Chinese older adults by sociodemographic characteristics, disease burden, geographic region....
Background: Inflammation has been reported to play an important role in frailty syndrome. The neutrophil-lymphocyte ratio (NLR) recently emerged as informative marker for systematic inflammation. However, few studies have examined the association between NLR and frailty. This study aims examine community-dwelling older adults. Methods: Community-dwelling adults aged ≥ 65 years 2011 (n = 2,354) 2014 2,458) waves of Chinese Longitudinal Healthy Longevity Survey (CLHLS) were included. Frailty...
Abstract Background studies comparing different frailty measures in intensive care unit settings are lacking. We aimed to compare the index based on physiological and laboratory tests (FI-Lab), modified (MFI) hospital risk score (HFRS) predict short-term outcomes for critically ill patients. Methods we conducted a secondary analysis of data from Medical Information Mart Intensive Care IV database. Outcomes interest included in-hospital mortality discharge with need nursing care. Results...
This study aimed to explore the associations between different types of meat consumption and mortality risk among people with frailty.
Abstract Background The utility of aging metrics that incorporate cognitive and physical function is not fully understood. Objective We aim to compare the predictive capacities 3 distinct metrics—motoric risk syndrome (MCR), physio-cognitive decline (PCDS), frailty (CF)—for incident dementia all-cause mortality among community-dwelling older adults. Methods used longitudinal data from waves 10-15 Health Retirement Study. Cox proportional hazards regression analysis was employed evaluate...
The increasing risk posed by space debris highlights the need for accurate localization techniques. Spaceborne single photon Lidar (SSPL) offers a promising solution, overcoming limitations of traditional ground-based systems providing expansive coverage and superior maneuverability without being hindered weather, time, or geographic constraints. This study introduces novel approach leveraging non-parametric Bayesian inference Dirichlet process mixture model (DPMM) to accurately determine...
Abstract Backgrounds Little is known about the role of frailty in recovery process disability among older adults. We examined association between and from activities daily living (ADL) instrumental ADL (IADL) community-dwelling Chinese Methods Data were China Health Retirement Longitudinal Study. Three waves used. Participants ≥60 years, had assessment at baseline, incident or IADL 2013, 2015 included. Recovery used as outcome measure. Multivariable logistic regression was to evaluate...
The prognostic significance of obstructive sleep apnea (OSA) in elderly patients with type 2 diabetes is unclear. aim this study was to determine the risk cardiovascular disease (CVD) and mortality OSA complicated compared without diabetes.From January 2015 October 2017, 1113 eligible OSA, no history cardiovascular, ≥60 years age, complete follow-up records were enrolled consecutive multicentre prospective cohort study. All had completed polysomnography (PSG) examinations. An...
Background: Motoric cognitive risk (MCR) syndrome is considered to be a pre-dementia syndrome. Although an increasing number of studies have begun focus on this syndrome, few investigations been launched in China. This study was performed examine the prevalence and correlates MCR Methods: We included 5,725 adults aged over 60 years from China Health Retirement Longitudinal Study (CHARLS). defined as presence subjective complaints gait speed ≤20th percentile weighted population distribution...
Background: Sleep is increasingly recognized as an important lifestyle contributor to health; however, its relationship with Motoric cognitive risk syndrome (MCR) still unclear. The present study aimed examine the associations between sleep duration, quality, and MCR among community-dwelling Chinese older adults. Methods: We recruited 5,387 participants aged ≥60 years from China Health Retirement Longitudinal Study (CHARLS). Sleep-related variables including night duration quality were...