A5047710605- Obstructive Sleep Apnea Research
- RNA modifications and cancer
- Cardiovascular and Diving-Related Complications
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Cancer-related gene regulation
- Cardiovascular Health and Disease Prevention
- Tannin, Tannase and Anticancer Activities
- Voice and Speech Disorders
- Epigenetics and DNA Methylation
- Dysphagia Assessment and Management
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Climate Change and Health Impacts
- Neuroscience of respiration and sleep
- Chemokine receptors and signaling
- Tracheal and airway disorders
- Cancer-related Molecular Pathways
- Anesthesia and Neurotoxicity Research
Yan'an University
2014-2025
Shanghai Sixth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023
Chinese PLA General Hospital
2021
Northwestern Polytechnical University
2019
Xi'an Jiaotong University
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Institute of Hematology & Blood Diseases Hospital
2000-2008
Dong-A University
2007
Purpose: This study was done to investigate the inhibition effects of miR-30a-3p on mitotic arrest deficient 2 like 1 (MAD2L1) expression and proliferation gastric cancer cells. Patients methods: Cluster analysis TCGA database were used screen key genes highly expressed in cancer. Based LinkedOmics website, correlation between cell cycle-related target gene MAD2L1 analyzed. The mRNA protein levels detected with quantitative real-time PCR Western blot analysis. cycle also Results:...
Introduction:Phellinus igniarius (P. igniarius) (Sanghuang) is a widely used traditional Chinese medicine fungus, and its natural products have great potential for clinical application in immune enhancement. This study aimed to explore the immune-enhancing activity underlying mechanisms of polysaccharides flavonoids derived from Phellinus provide theoretical experimental basis development novel drugs. Methods: Wild P. YASH1 Loess Plateau Yan'an region was collected, total were extracted,...
Rotational atherectomy is an effective method for treating severe coronary artery calcification; however, several challenges in its clinical application persist. This study aimed to compare the safety and effectiveness of rotational combined with cutting balloon (RACB) versus plain (RAPB) patients heavily calcified lesions. retrospective observational cohort included 326 who underwent at Shanghai Sixth People's Hospital from January 2016 December 2022. Patients were divided into two groups...
Objective: To assess the associated factors of employment intention among contemporary nursing graduates. Background: In postepidemic era, shortage nurses and decline in rate have garnered significant attention globally. It is crucial to evaluate with intentions graduates address issue nurse shortage. So far, existing research on China has mainly focused examining relationship between individual intentions. However, there a notable lack systematic grounded scientific theories that predicts...
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate enzyme involved in folate metabolism. The aim of this study to determine the effect MTHFD2 on proliferation and metastasis colorectal cancer (CRC).MTHFD2 was silenced or overexpressed CRC cells. qRT-PCR Western blotting were used analyze mRNA protein expression, respectively. MTT assay colony forming detect cell formation ability. cycle apoptosis changes detected by flow cytometry. Transwell experiments migration...
The prognostic significance of obstructive sleep apnea (OSA) in elderly patients with type 2 diabetes is unclear. aim this study was to determine the risk cardiovascular disease (CVD) and mortality OSA complicated compared without diabetes.From January 2015 October 2017, 1113 eligible OSA, no history cardiovascular, ≥60 years age, complete follow-up records were enrolled consecutive multicentre prospective cohort study. All had completed polysomnography (PSG) examinations. An...
Abstract Background Abnormal expression of ribosomal proteins has an important regulatory effect on the progression cancer. RPL5 is involved in various malignancies, however, role colon cancer remains still unclear. Methods Data from TCGA and GTEx databases were used to analyze pan-cancer. The level clinical tissue samples human cell lines was detected by western blotting; siRNA targeting designed, its interference efficiency verified blotting RT-qPCR; CCK8 assay, clone formation cycle...
The objective of the present study was to investigate effects mesenchymal stem cells (MSCs) genetically modified by lentivirus‑mediated mouse interleukin‑12 (Lenti‑mIL‑12) in treating malignant ascites mice. vitro chemotactic effect Lenti‑mIL‑12‑MSC culture supernatant on dendritic investigated using a chemotaxis chamber. Liver cancer H22 and MethA models were constructed. Mice divided evenly into four groups: Normal saline, MSC, Null Lenti‑mIL‑12‑MSC. survival rate, volume red blood cell...
Gastric cancer (GC) is one of the most common malignant around world, however mechanisms still unclear. In present study, we investigated function CREB3 regulatory factor (CREBRF) in human GC and explored its relevant molecular mechanism. We found that CREBRF was highly expressed primary tissues expression level associated with clinicopathologic characteristics GC. silencing inhibited cell proliferation induced G1/G0 to S phase cycle arrest through regulating Cyclin A, D1 CDK2 expressions....
The adrenergic system contributes to the stress-induced onset and progression of cancer. Adrenergic fibers are primary source norepinephrine (NE). underlying mechanisms involved in NE-induced colon cancer remain be understood. In this study, we describe function regulatory network NE We demonstrate that phosphorylation cAMP response element-binding protein 1 (CREB1) promotes proliferation, migration, invasion human cells. downstream effector NE, CREB1, bound promoter miR-373...
Evidence suggests that an increased risk of major adverse cardiac events (MACE) and all-cause mortality is associated with obstructive sleep apnea (OSA), particularly in the elderly. Metabolic syndrome (MetS) increases cardiovascular general population; however, less known about its influence patients OSA. We aimed to assess whether MetS affected MACE elderly OSA.From January 2015 October 2017, 1,157 OSA, aged ≥60 years, no myocardial infarction (MI), hospitalization for unstable angina or...
Abstract Purpose It is reported that insomnia and obstructive sleep apnea (OSA) increase the incidence of adverse cardiovascular events. The aim this study was to analyze risk disease mortality in elderly patients with comorbid (COMISA). Methods We included 868 OSA who underwent monitoring at a multicenter room from January 2015 October 2017. collected demographic data, clinical features, medical history, parameters, laboratory findings. Cox proportional hazards analysis used identify...
The present study aimed to investigate the effect of inhibition miR‑145 on cyclin‑dependent protein kinase 6 (CDK6) and proliferation human cervical carcinoma cells. sequence was synthesized cloned into pcDNA™6.2‑GW construct recombinant plasmid pcDNA6.2‑GW‑miR‑145. HeLa cells were divided micro (mi)R‑145, normal control blank groups. transcription levels CDK6 detected using quantitative polymerase chin reaction western blot analysis used examine expression. In addition, inhibitory measured...
While growing evidence indicates the importance of TFF3 in cancer, molecular mechanism its action cancer remains largely unknown. Clonogenic survival is a key ability for tumor cells, which interpreted as trait cells with tumor-initiating capabilities. We investigated effect and underlying mechanisms on clonogenic colorectal (CRC) cells.Expression CRC tissues matched paracancerous was determined by western blotting. Colony formation assays were performed to evaluate cells. PTGER4 mRNA...
The aim of the present study was to investigate effects paroxetine on spatial memory and expression level protein kinase C (PKC) in a rat model depression. Rat models depression were established by chronic unpredictable mild stress. learning function rats assessed Morris water maze test. levels PKC hippocampus detected western blotting. results showed that, compared with control group, escape latency prolonged percentage time target quadrant number times crossed platform reduced group;...
This study sought to identify the changes and potential association between sleep characteristics short-term memory, mood states among volunteers at different altitudes times.A total of 26 healthy were recruited from PLA General Hospital, we conducted a longitudinal prospective survey for over 1 year November 2019 April 2021. First, collected demographic data, parameters by overnight polysomnography (PSG), memory digit span test, completing questionnaire with brief profile participants in...
Abstract Purpose This study sought to identify the prevalence and factors associated with atrial fibrillation (AF) in older patients obstructive sleep apnea (OSA) China. Methods was an explorative cross-sectional study. Between January 2015 October 2017, we continuously recruited 1285 OSA who underwent overnight polysomnography from centers of multiple hospitals. They were assessed using 12-lead ECG or 24-h dynamic ECG, their baseline demographics, clinical characteristics, parameters,...
The study is aimed at investigating the role of Nei endonuclease VIII-like1 (NEIL1) in pathogenesis colorectal cancer (CRC). human CRC (HCT116 and SW480) cells were subjected to siRNA silencing recombinant plasmid overexpression NEIL1. Transfection siNEIL1 significantly inhibited cell growth. It also increased Bax expression levels, while it decreased Bcl-2 levels cells, leading Bax/Bcl-2 balance toward apoptosis. Moreover, apoptosis was promoted through caspase-9 signaling pathway. One...
We aim to investigate the role of THAP11 (thanatos-associated protein11) in gastric cancer and its regulation mechanisms. expression was analyzed 51 pairs GC tissues corresponding paracancerous by qRT-PCR Western blot. After overexpressed or knocked-down, cell proliferation, cycle, apoptosis were detected MKN-45 cells. found that significantly downregulated lines. Functionally, overexpression markedly inhibited growth, induced G1/G0 cell-cycle arrest, promoted cells, while silencing led...
Abdominal obesity (AO) is a well-known independent risk factor for stroke in the general population although it remains unclear case of elderly, especially Chinese older patients with obstructive sleep apnea (OSA), considering paradox. This study aimed to investigate association between AO and among OSA.Data were collected from January 2015 October 2017, 1,290 (age 60-96 years) OSA (apnea-hypopnea index ≥ 5 events/h on polysomnography) consecutively enrolled centers at six hospitals,...
This study is to investigate the expression of methyl CpG binding protein 2 (MECP2) in gastric cancer (GC) and its clinical significance. Expression MECP2 was analyzed 69 cases GC tissues 12 paracancerous tissues, either by qRT-PCR at mRNA level or Western blot immunochemistry level. The correlation with clinicopathological parameters patients, validated data from TCGA database. effect on survival also investigated. significantly increased both levels compared tissues. positive correlated...