A5101935317- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Scheduling and Optimization Algorithms
- Manufacturing Process and Optimization
- Assembly Line Balancing Optimization
- Advanced Queuing Theory Analysis
- Immunotherapy and Immune Responses
- Neuropeptides and Animal Physiology
- Product Development and Customization
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Optimal Power Flow Distribution
- Wireless Communication Networks Research
- Power System Reliability and Maintenance
- Protein Degradation and Inhibitors
- Operations Management Techniques
- Chemical Synthesis and Analysis
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Electric Power System Optimization
First Affiliated Hospital of Xi'an Jiaotong University
2004-2023
Alibaba Group (China)
2021-2022
Nanyang Technological University
2015-2018
Xi'an Jiaotong University
2014
Huazhong University of Science and Technology
2008-2011
First Hospital of Xi'an
2004
The adrenergic system contributes to the stress-induced onset and progression of cancer. Adrenergic fibers are primary source norepinephrine (NE). underlying mechanisms involved in NE-induced colon cancer remain be understood. In this study, we describe function regulatory network NE We demonstrate that phosphorylation cAMP response element-binding protein 1 (CREB1) promotes proliferation, migration, invasion human cells. downstream effector NE, CREB1, bound promoter miR-373...
Multiple myeloma (MM) is a heterogeneous plasma cell malignancy and remains incurable. B-cell lymphoma-2 (BCL2) protein correlates with the survival drug resistance of cells. BH3 mimetics have been developed to disrupt binding between BCL2 its pro-apoptotic family partners for treatment MM, but limited therapeutic efficacy. We recently identified small molecule BDA-366 as BH4 domain antagonist, converting it from an anti-apoptotic into molecule. In this study, we demonstrated that induces...
Semiconductor manufacturing processes often come with stringent requirements for product quality. In order to satisfy these requirements, time window constraints have been imposed. Typically, violation of the windows can result in a lot being either reworked or scrapped. The presence overlapped renders control production lines very challenging as it involves managing process many lots across multiple workstations. We study performance line deterministic service times and predetermined,...
Objective: This study aimed to investigate the effect of tetra-arsenic tetra-sulfide on treating multiple myeloma and its potential regulation suppressor cytokine signaling 1 methylation-mediated Janus kinase 2/signal transducer activator transcription 3 pathway. Methods: Tetra-arsenic with different concentrations were used treat U266 cells, cell viability was measured at 12, 24, 48 hours 0 μM treatment as control by Cell Counting Kit-8 assay. Suppressor methylation expression determined...
Multiple myeloma (MM) is an incurable B-cell cancer with accumulated clonal abnormal plasma cells in bone marrow of patients. MCL-1 (myeloid cell leukemia sequence 1) protein anti-apoptotic molecule MM and regulated by pro-inflammatory cytokine IL-6 downstream signaling molecules STAT3, PI3K MAPK. The purpose this study to investigate the effect MAPK gene silence on expression human consequence survival. Lentivirus small hairpin RNA (shRNA) interference techniques were utilized knock down or...
Abstract Background DNA methylation played a crucial role in the pathogenesis of immune thrombocytopenia (ITP). However, genome-wide analysis has not been applied thus far. The present study aimed to provide first profiling for ITP. Methods Peripheral blood CD4 + T lymphocytes samples were collected from 4 primary refractory ITP cases and age-matched healthy controls, methylome was performed using Infinium MethylationEPIC BeadChip. Differentially methylated CpG sites further validated...
Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. presence arrhythmias can lead to worse outcomes. Therefore, this study aimed evaluate the potential heart rate (HR) hypertension in predicating outcomes MM patients. Methods: This retrospectively enrolled between January 1, 2010, December 31, 2018, at First Affiliated Hospital Xi'an Jiaotong University. endpoint was all-cause mortality. Pearson's chi-square test...
The expression level of BCMA in bone marrow 54 MM patients was detected this study to explore the relationship between and classification, stage, prognostic factors MM. stable group remission lower than that newly diagnosed relapse (P=0.001). There no significant difference different types stages (P>0.05), but it found for patients, IgG higher IgA or light-chain (rank average 11.20 vs 5.44, P=0.014). correlation age serum creatinine (P>0.05). And there with levels But...
To evaluate the efficacy and toxicity of etoposide cyclophosphamide for mobilization peripheral stem cells in multiple myeloma patients.We retrospectively analyzed 46 patients with who underwent blood cell collection upfront autologous hematopoietic transplantation First Affiliated Hospital Xi'an Jiaotong University between January 2010 July 2019. The protocols included 2.0 g/m2 G-CSF (CTX group) before 2015, two-days 5 mg/kg.d 1.0 g/m2.d (EC after 2015.The success rate harvest (≥2×106...
In this paper, we study a MAP/PH/1 queue with two classes of customers and discretionary priority. There are stages service for the low-priority customer. The server adopts preemptive priority discipline at first stage nonpreemptive second stage. Such queueing system can be modelled into quasi-birth-and-death (QBD) process. But there is no general solution QBD process since generator matrix has block structure an infinite number blocks each dimensions. We present approach to derive bound...
The increasing variety of products complicates the mixed-model assembly process and affected system in terms product quality productivity. In paper, induced manufacturing complexity with regard to choices that operators have make for various operations is measured information entropy average randomness choice processes. impact error rate associated on performance analyzed by means investigation reaction time speed-accuracy trade-off. addition, an established artificial neural network...
Security-constrained unit commitment (SCUC) is the foundation to ensure safe and economic operation of power systems. A large number integer variables complex network security constraints are main barriers that limit computation efficiency SCUC problem. In this paper, congestion information used identify units play a key role in alleviating transmission congestion, process iterative solving SCUC. Then statuses non-critical fixed, reduced. Additionally, neighborhood search cutting plane...