A5043630193- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Hip and Femur Fractures
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Microplastics and Plastic Pollution
- Food Science and Nutritional Studies
- Chromium effects and bioremediation
- Metastasis and carcinoma case studies
- Chemokine receptors and signaling
- Agriculture, Soil, Plant Science
- Composting and Vermicomposting Techniques
- interferon and immune responses
- Hepatitis Viruses Studies and Epidemiology
- Gold and Silver Nanoparticles Synthesis and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Frailty in Older Adults
- Proteoglycans and glycosaminoglycans research
- Immune cells in cancer
- Orthopedic Infections and Treatments
Chinese University of Hong Kong, Shenzhen
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Liuzhou General Hospital
2024-2025
Peking Union Medical College Hospital
2011-2025
Shenzhen University
2025
Central South University of Forestry and Technology
2025
Central South University
2025
Guangxi Medical University
2024
Background The global burden of non-alcoholic steatohepatitis (NASH)-related liver cancer (NRLC) is increasing, making NASH the fastest-growing cause worldwide. This study presents a comprehensive analysis NRLC at global, regional, and national levels, further categorized by age, sex, sociodemographic index (SDI). Method Data on from Global Burden Disease, Injuries, Risk Factors (GBD) 2021 were downloaded levels. numbers age-standardized rates (ASRs) incidence, mortality, disability-adjusted...
Abstract Background and Aims Acute hepatitis E (AHE) is still a public health issue worldwide. Here, we report the global burden of AHE in 204 countries territories from 1990 to 2019 by age, sex socio‐demographic index (SDI), predict future trends 2030. Methods Data on were collected Global Burden Diseases, Injuries Risk Factors Study 2019. The average annual percentage change (AAPC) joinpoint analysis used determine trend. Results In 2019, there 19.47 million (95% UI, 16.04 23.37 million)...
Abstract Surface‐enhanced Raman scattering (SERS) substrates based on 2D semimetallic materials have emerged as novel detecting platforms for at the single‐molecule level due to high charge transfer efficiency between layered and analytes. However, current methods such chemical vapor deposition (CVD) or liquid‐phase exfoliation face significant challenges in simultaneously achieving yield low defect density preparing materials, which often leads compromises SERS sensitivity, thereby limiting...
ABSTRACT Background The current focus of cardiac rehabilitation is on adults, with no standard nursing plan available for children congenital heart disease. Therefore, it very necessary to develop a standardized early model disease promote the recovery bodily functions and improve quality life in this population. Purpose This study was designed explore feasibility an graded postoperative evaluate its clinical effect standardization care. Methods One hundred sixteen treated at medical...
CD44, a transmembrane glycoprotein expressed in variety of cells and tissues, has been implicated tumour metastasis. But the molecular mechanisms CD44-mediated cell metastasis remain to be elucidated. The downregulation CD44 was determined by immunofluorescence. Moreover, motility breast cancer detected wound-healing transwell experiments. Then spontaneous CD44-silenced MDA-MB-231 tested histology with BALB/c nude mice. A positive correlation between Na+/H+ exchanger isoform 1 (NHE1) found...
Objective: To explore the correlation between quadriceps thickness (thickness of rectus femoris and vastus intermedius), cross-sectional area (cross-sectional femoris) strength score Medical Research Council (MRC) in critically ill patients, to changes length hospital stay intensive care unit (ICU), determine diagnostic value muscle ICU-acquired weakness (ICU-AW). Methods: Patients admitted Department Critical Care Medicine from March October 2019 who were expected for more than five days...
Abstract Background: The dual blockade of HER2 signaling with trastuzumab (T) + pertuzumab (P) has been shown to be highly active low toxicity in patients (pts) positive breast cancer both the neoadjuvant and metastatic setting even absence chemotherapy. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate combining antitumor properties cytotoxic agent DM1 via a stable linker. T-DM1 was more efficacious less toxic than combination docetaxel T pts (MBC). Based on these data we decided...
Profiling is a process that finds similarities between different RNA secondary structures by extracting signals from the Boltzmann sampling. The reproducibility of profiling can be identified standard deviation number features among samples. We found strong relationship frequency each helix class and its upon repeated developed perturbation technique to predict stability these featured classes without need for sampling, with accuracy 84% 94%, depending on type RNA. Our only requires 0.2%...
Background: Branched-chain amino acid metabolism is involved in the pathogenesis of various liver diseases. In this study, we investigate potential role branched-chain metabolism-related genes hepatic ischemia reperfusion (HIRI). Methods: The gene Expression profiles HIRI were obtained from Gene Omnibu database. To determine differential expression between and normal tissues. Then, GO KEGG analyses performed, protein-protein interaction network was constructed. Next, random forest LASSO...
Abstract Background: It is supposed that triple negative breast cancer (TNBC) may be more sensitive to DNA damage agents such as platinum. This study was designed compare platinum-based regimen (docetaxel plus cisplatin) with non-platinum-based capecitabine) in the first-line treatment of advanced patients. Patients and Methods: a single-institution, randomized phase II clinical trial. Eligible TNBC women first relapse or metastasis who had measurable disease were (1:1) receive either TP...
Objective: The 6th edition American Joint Committee on Cancer (AJCC) staging system for breast cancer classifies ipsilateral supraclavicular lymph node metastasis (ISLM) downing stage from M1 to N3, suggesting more patients might receive radical treatment. aim of this study was analyze the effect ISLM prognosis N3 and verify rationality modified staging. Methods: A total 321 with according AJCC were retrospectively analyzed. Propensity Score Matching (PSM) used pair different subgroups N3....
HLA-B*27:149 differs from HLA-B*27:04:01 (488C->T, exon 3, A139V).
Abstract Background: Giving the high degree of efficacy and safety profile, Docetaxel/Paclitaxel in combination with Capecitabine are indicated as 1st line standard chemotherapy for anthracycline pretreated or resistant metastatic breast cancer (MBC) patients. Maintenance is administered to patients without progression after an initial chemotherapy, generally treatment. Unfortunately, no clinical studies has prospectively evaluated capecitabine single agent maintenance MBC. Methods:...
HLA-C*06:166 differs from HLA-C*06:02:01:01 (146T → C, exon 2, V25A).
Abstract Background: Metastatic breast cancer remains an incurable disease, and clinical benefit progression-free survival are the main end points in advanced setting. Targeted therapies have shown promising potentials HER2-positive cancer, but with uncertain effects HER2-negative especially when disease is progressing rapidly. The regimen of antiangiogenic therapy combination chemotherapy had been studied for years gained improved efficacy. Apatinib oral, highly potent tyrosine kinase...