A5114198394- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Potassium and Related Disorders
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Parkinson's Disease and Spinal Disorders
- Advanced Breast Cancer Therapies
- Radiation Therapy and Dosimetry
- Histone Deacetylase Inhibitors Research
- Sirtuins and Resveratrol in Medicine
- CNS Lymphoma Diagnosis and Treatment
- Chemokine receptors and signaling
- Sinusitis and nasal conditions
Guangdong Pharmaceutical University
2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2025
Institute of Hematology & Blood Diseases Hospital
2013-2024
Zoucheng People's Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2023
Peking Union Medical College Hospital
2023
Shanxi Medical University
2023
Hangzhou Cancer Hospital
2023
Zhejiang University
2023
National Clinical Research
2022
Background Acute type A aortic dissection (AAD) and acute intramural hematoma (AIMH) are life‐threatening conditions with high mortality rates, prognostic indicators critical for guiding urgent treatment decisions. We assessed the significance of admission D‐dimer levels in patients AAD AIMH. Methods Results The prospective, multicenter, observational study China recruited participants from 2013 to 2019. Patients AIMH were respectively categorized into quartiles based on levels. Cox...
Introduction There are about 2,300,000 new cases of breast cancer worldwide each year. Breast has become the first most common in world and leading cause death among women. At same time, chemotherapy resistance patients with advanced is still a serious challenge. Alpinia Katsumadai Hayata (AKH), as traditional Chinese herbal medicine, wide range pharmacological activities. Related studies have found that many compounds AKH anti-breast activity. However, it worth exploring which component...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent hepatic disorder with high morbidity and mortality. Licochalcone A (LiA) exhibits significant therapeutic efficacy in obesity through diverse pharmacological mechanisms. This study aimed to explore underlying mechanism of LiA attenuating MASLD, which requires further investigation. Male C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks establish MASLD mouse model. The lipid level function evaluated...
Introduction and Aims: Hyperkalaemia is a risk factor for mortality in patients with cardiovascular disease chronic kidney (CKD) (Goyal, 2012; Torlen, 2012) limits use of renin-angiotensin-aldosterone system inhibitors (RAASi) these patients. Sodium (or calcium) polystyrene sulfonate (SPS/CPS) has uncertain efficacy been associated substantial adverse events, as well poor gastrointestinal tolerability, hence suboptimal acute unsuitable (Harel, 2013; Sterns, 2010). Therefore, there need...
To explore the relationship between dietary fiber (DF) intake and hyperkalemia in maintenance hemodialysis (MHD) patients. A total of 110 MHD patients were included, including 67 males 43 females. Patients divided into normal serum potassium group (N) a (H) according to level before dialysis. The daily diet was recorded by 3-day recording method. nutrient analyzed. Logistic regression used analyze DF intake. receiver operating characteristic curve cutoff value prevent hyperkalemia. Of...
Objective: This study aimed to summarize the clinical characteristics and prognosis of patients with bone marrow invasive follicular lymphoma (FL) discuss treatment modalities. Methods: included 183 consecutive FL accompanied by invasion receiving regular at Hospital Hematology, Chinese Academy Medical Sciences, from January 2013 December 2022. Clinical data were retrospectively collected analyzed, single multifactorial analyses survival conducted Kaplan-Meier method Cox regression model....
Objective: To investigate the clinical features of Pre-Crisis State and analyze correlated risk factors myasthenia crisis. Methods: We included 93 patients with gravis (MG) who experienced 127 times between October 2007 July 2016. Those were hospitalized in MG specialize center, Department Neurological Science, first Affiliated Hospital Sun Yat-sen University. The information general situation, manifestations blood gas analysis those collected using our innovated research form. Statistic...
Introduction: Zanubrutinib (zanu) is a potent and highly selective next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy minimize off-target effects. In the ALPINE study (NCT03734016), zanu demonstrated superiority ibrutinib (ibr) in both progression-free survival (PFS) overall response rate more favorable safety profile R/R CLL/SLL. The purpose of this analysis was assess health-related quality life (HRQOL) patients (pts) treated with ibr. Results from...
Introduction: The efficacy and safety of chidamide, a novel subtype-selective histone deacetylase (HDAC) inhibitor, have been demonstrated in pivotal phase 2 clinical trial (CHIPEL study) were recently approved by China Food Drug Administration (CFDA) for the treatment patients with relapsed or refractory peripheral T cell lymphoma (PTCL). purpose this post-marketing surveillance study was to further elucidate real-world utilization chidamide PTCL. Methods: Patients confirmed PTCL who...
Background: In the phase 3 ALPINE trial (BGB-3111-305; NCT03734016), efficacy and safety of zanubrutinib, a highly selective, next-generation Bruton tyrosine kinase inhibitor (BTKi), were compared with first-generation BTKi, ibrutinib, in adult patients RR chronic lymphocytic leukemia/small lymphoma (CLL/SLL). Aims: This abstract, based on interim analysis trial, describes effects zanubrutinib monotherapy ibrutinib health-related quality life (HRQoL). Methods: Health-related was examined by...
To investigate the prognostic significance of detection minimal residual disease after first induction treatment (MRD(1)) in adult acute lymphoblastic leukemia (ALL) patients treated with autologous stem cell transplantation (auto-HSCT).
Objective: To investigate the effect of long non-coding RNA-AC013472.3 on lipopolysaccharide (LPS)-stimulated secretion tumor necrosis factor (TNF)-α in NR8383 rat alveolar macrophages. Methods: Silencing and overexpression models lncRNA-AC013472.3 were established with macrophages as experimental subjects. The silencing divided into three groups: random nonsense negative small interfering RNA sequence (si-con) group (si-con group, si-con transfected cells), LPS+si-con (10 μg/L LPS was used...
Objective: To explore the role of cell division cycle protein 37 (Cdc37) mediating bortezomib (BTZ) resistance in multiple myeloma (MM) via regulation autophagy activity to provide a novel strategy for MM therapy. Methods: The expressions Cdc37 and LC3b were investigated BTZ-resistant line ANBL-6.BR using quantitative real-time PCR (qRT-PCR) western blot (WB) analysis. was upregulated cells owing lentivirus transfection. expression detected with WB, BTZ-induced apoptosis explored flow...
Objective: To study the clinicopathologic features of plasma cell myeloma(PCM) with bone marrow fibrosis (MF). Methods: The data 175 cases newly diagnosed PCM patients were retrospectively analyzed. Based on reticular fiber staining, these divided into PCM-MF and non-PCM-MF groups. Results: Sixty-three PCM-MF(36%), 112 (64%). No statistical difference in gender, age, hemoglobin level, platelet counts, classification immunoglobulin, ISS staging, immunohistochemical phenotypes genetic was...
Objective: To summarize and investigate the characteristics, prognosis treatments of chronic lymphocytic leukemia (CLL) patients with trisomy 12 by using FISH (CEP12). Methods: Clinical data 330 CLL were analyzed retrospectively (CEP12) to detect from May 2003 April 2015. The clinical laboratory characteristics CEP12 positive (70 cases) compared those negative (260 cases). Results: Compared patients, proportion hepatomegaly (13.6% vs 4.0%, P=0.011) LDH>247 U/L (43.3% 18.5%, χ(2)=15.892,...