A5091669272- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Ophthalmology and Visual Impairment Studies
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Ophthalmology and Eye Disorders
- Chemokine receptors and signaling
- Cerebral Venous Sinus Thrombosis
- Esophageal Cancer Research and Treatment
- Ultrasound in Clinical Applications
- Retinal Imaging and Analysis
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Airway Management and Intubation Techniques
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Gastroesophageal reflux and treatments
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
Zhujiang Hospital
2018-2025
Southern Medical University
2018-2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2023-2025
Nanjing University of Chinese Medicine
2023-2024
People's Hospital of Shiyan
2023
Zigong First People's Hospital
2022-2023
Sun Yat-sen University
2013-2022
Hainan Eye Hospital
2020-2022
Beijing Institute of Big Data Research
2022
Wenzhou Hospital of Traditional Chinese Medicine
2021
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), and reducing sorafenib resistance an important issue to be resolved the clinical treatment of HCC. In current study, we identified that ABCC5 critical regulator promising therapeutic target acquired in human cells. The expression was dramatically induced sorafenib-resistant HCC cells remarkably associated with poor prognoses. down-regulation could significantly reduce Importantly, activation...
As a newly approved oral hypoglycaemic agent, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin, which is derived from natural product phlorizin can effectively reduce blood glucose. Recent clinical studies have found that dapagliflozin alleviates non-alcoholic fatty liver disease (NAFLD), but specific mechanism remains to be explored. This study aimed investigate underlying of in alleviating hepatocyte steatosis vitro and vivo . We fed spontaneous type diabetes mellitus...
Summary: Taurine (Tau) has been found to inhibit triple-negative breast cancer (TNBC) invasion and metastasis. However, its effect on tumor-promoting macrophages tumor suppressor in progression remains unknown. In this study, we investigated the effects of Tau macrophage polarization role TNBC cell growth, invasion, We induced human THP-1 monocytes differentiate into M2 through exogenous addition interleukin-4. used lines MDA-MB-231 BT-549 cultured a conditioned medium from investigate...
We compared the choroidal thickness of eyes patients with acute primary angle-closure (APAC) fellow in same patients.The analysis included 21 participants unilateral APAC affected and a diagnosis suspect (PACS). Enhanced depth imaging-optical coherence tomography (EDI-OCT) was used to measure macular peripapillary retinal both eyes. The average at each location or segment that eyes.At all locations, greatest subfovea for groups. Comparison between groups showed significantly greater than...
Introduction There are about 2,300,000 new cases of breast cancer worldwide each year. Breast has become the first most common in world and leading cause death among women. At same time, chemotherapy resistance patients with advanced is still a serious challenge. Alpinia Katsumadai Hayata (AKH), as traditional Chinese herbal medicine, wide range pharmacological activities. Related studies have found that many compounds AKH anti-breast activity. However, it worth exploring which component...
Abstract Background Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms CTC colonisation pre-metastatic niches. Methods Detection classification CTCs patients were performed using CanPatrol™ system. A lentiviral vector expressing Prrx1-targeting shRNA was constructed generate a stable HCC cell line with...
Purpose.: To evaluate changes of levels erythropoietin (EPO) and VEGF in aqueous humor before after an intravitreal injection bevacizumab (IVB) determine the underlying correlation between them.
Background Neovascular glaucoma (NVG) is a refractory disease which difficult to manage. This study aimed at evaluating the efficacy and safety of adjunctive intravitreal bevacizumab (IVB) injection in conjunction with Ahmed valve implantation (AGVI) management NVG. Methods was retrospective patients NVG whom AGVI performed between October 2008 May 2012. The sample divided into two groups according pretreatment: IVB (the group, n =25 eyes) without control =28 eyes). surgical success rate,...
Triple negative breast cancer is known for its visceral metastasis. We have found that CXCR4 overexpressed in triple and associated with further investigated whether a prognostic factor affecting survival following metastasis patients. Our results indicate increased expression among patients was positively correlated poor overall (P<0.001). Silencing of decrease the tumorigenic properties MDA-MB-231 cells, caused reversion EMT suppression MMP-9, apoptosis, reduced incidence tumor lung mice....
Patients treated in the intensive care unit (ICU) are closely monitored and receive treatment. Such aggressive monitoring treatment will generate high-granularity data from both electronic healthcare records nursing charts. These not only provide infrastructure for daily clinical practice but also can help to inform studies. It is technically challenging integrate cleanse medical a variety of sources. Although there several open-access critical databases western countries, lack this kind...
<h3>Purpose</h3> To determine if the anterior choroid is involved in ocular change during Valsalva manoeuvre (VM). <h3>Materials and methods</h3> Fifty-three healthy volunteers aged 18–65 years with normal visual field test results no history of intraocular pressure (IOP) exceeding 21 mm Hg were recruited. Anterior posterior choroidal changes before VM recorded by ultrasound microscope swept-source optical coherence tomography, respectively. Parameters segment included ciliary body thickness...
Hepatocellular carcinoma (HCC) is an aggressive form of cancer characterized by a high recurrence rate following resection. Studies have implicated stromal and immune cells, which part the tumor microenvironment, as significant contributors to poor prognoses HCC patients. In present study, we first downloaded gene expression datasets for patients from The Cancer Genome Atlas database categorized into low or score groups. By comparing those groups, identified differentially expressed genes...
Purpose: Obtaining a better understanding of the pathogenesis primary angle-closure disease (PACD) still requires studies that provide measurements anterior and posterior biometric characteristics together assess relationship between them. Methods: In total, 201 eyes were enrolled in this cross-sectional study: 50 normal controls, 49 suspect (PACS), 38 angle closure (PAC), 64 glaucoma (PACG) eyes. The structural features measured by segment optical coherence tomography swept-source...
Disulfidptosis is a novel form of cell death triggered by disulfide stress that may have important implications for breast cancer (BC) pathogenesis. Nevertheless, studies identifying disulfidptosis-associated long non-coding RNAs (lncRNAs) in BC not been reported. This study aimed to investigate the prognostic potential disulfidptosis-related lncRNAs BC.
The process of islet transplantation for treating type 1 diabetes has been limited by the high level graft failure. This may be overcome locally delivering trophic factors to enhance engraftment. Regenerating islet-derived protein 3α (Reg3α) is a pancreatic secretory which functions as an antimicrobial peptide in control inflammation and cell proliferation. In this study, investigate whether Reg3α could improve engraftment, marginal mass syngeneic islets pretransduced with adenoviruses...
To evaluate changes in the concentrations of placental growth factor (PlGF) and vascular endothelial factor-A (VEGF-A) aqueous humor patients with neovascular glaucoma (NVG) before after an intravitreal injection ranibizumab (IVR) to determine underlying correlation between levels.The prospective interventional comparative study involved 20 eyes surgery-required advanced NVG control subjects from January 2013 November 2013. The received IVR treatment surgery. Aqueous was collected at time...
Liquid biopsy is attracting attention as a method of real-time monitoring patients with tumors. It can be used to understand the temporal and spatial heterogeneity tumors has good clinical application prospects. We explored new type circulating tumor cell (CTC) enrichment technology combined next-generation sequencing (NGS) analyze correlation between genomic alterations in cells hepatocellular carcinoma counts mesenchymal CTCs CTC-associated white blood (CTC-WBC) clusters.We collected...
Background Ahmed Glaucoma Valve implantation (AGVI) is used to treat refractory glaucoma. Breakdown of the blood-aqueous barrier (BAB) has been noted after some surgical techniques. The current study was designed assess BAB disruption AGVI. Methods Anterior chamber protein content measured by laser flare cell photometry in 22 eyes patients with glaucoma before AGVI and at each postoperative visit up 1 month. Results Before mean aqueous values all were (15.17±9.84) photon counts/ms[0]. After...
Purpose: The aim of the present study was to evaluate effect surgical peripheral iridectomy (SPI) on choroidal thickness in primary angle-closure suspect (PACS) eyes. Materials and Methods: This a prospective observational case series 30 subjects with PACS. Ocular biometry performed before SPI (baseline) then 1 week later. Choroid imaged by enhanced depth imaging optical coherence tomography (EDI-OCT). subfoveal area at 3 mm diameter around fovea determined. Central anterior chamber (ACD),...