A5032106625- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- interferon and immune responses
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Immune cells in cancer
Nanjing Medical University
2024-2025
Jiangsu Province Hospital
2024
Southern Medical University
2019-2022
Nanfang Hospital
2019-2022
Zhujiang Hospital
2019
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), and reducing sorafenib resistance an important issue to be resolved the clinical treatment of HCC. In current study, we identified that ABCC5 critical regulator promising therapeutic target acquired in human cells. The expression was dramatically induced sorafenib-resistant HCC cells remarkably associated with poor prognoses. down-regulation could significantly reduce Importantly, activation...
Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic...
Abstract Background Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms CTC colonisation pre-metastatic niches. Methods Detection classification CTCs patients were performed using CanPatrol™ system. A lentiviral vector expressing Prrx1-targeting shRNA was constructed generate a stable HCC cell line with...
Illustration of FCM nanoparticles synthesis and its anticancer mechanism, highlighting high microwave sensitivity thermal conversion efficiency for synergistic therapy (MTT) dynamic (MDT).