A5046037333- Advanced Database Systems and Queries
- Advanced Radiotherapy Techniques
- Algorithms and Data Compression
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- IL-33, ST2, and ILC Pathways
- Cardiac Fibrosis and Remodeling
- Perovskite Materials and Applications
- Asthma and respiratory diseases
- Data Management and Algorithms
- Immune cells in cancer
- Eosinophilic Disorders and Syndromes
- Medical Imaging Techniques and Applications
- Semantic Web and Ontologies
- Radiation Dose and Imaging
- Brain Metastases and Treatment
- Advanced X-ray and CT Imaging
- Head and Neck Cancer Studies
- Cloud Computing and Resource Management
- Quantum Dots Synthesis And Properties
- Social Media and Politics
- Ion Transport and Channel Regulation
- Parallel Computing and Optimization Techniques
- Advanced Data Storage Technologies
- Web Data Mining and Analysis
Guangdong Academy of Medical Sciences
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Xidian University
2024
Brigham and Women's Hospital
2019-2024
Harvard University
2019-2024
Southern Medical University
2024
Shijiazhuang University
2023
Huazhong University of Science and Technology
2018-2022
Nanjing Normal University
2022
Harvard University Press
2022
Understanding the function of moisture on perovskite is challenging since random environmental strongly disturbs structure. Here, we develop various N2-protected characterization techniques to comprehensively study effect efficient cesium, methylammonium, and formamidinium triple-cation (Cs0.05FA0.75MA0.20)Pb(I0.96Br0.04)3. In contrast secondary measurements, established air-exposure-free allow us directly monitor influence during crystallization. We find a controllable treatment for...
Clinical studies reveal changes in blood eosinophil counts and cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of or humans mice after myocardial infarction (MI), mostly the infarct region. Genetic inducible depletion eosinophils exacerbates cardiac dysfunction, cell death, fibrosis post-MI, with concurrent acute chronic splenic neutrophils monocytes. Mechanistic roles IL4 protein mEar1 blocking H2O2- hypoxia-induced mouse...
Blood eosinophil count and ECP (eosinophil cationic protein) associate with human cardiovascular diseases. Yet, whether eosinophils play a role in disease remains untested. The current study detected accumulation murine abdominal aortic aneurysm (AAA) lesions, suggesting participation this disease.
Background Acute type A aortic dissection (AAD) and acute intramural hematoma (AIMH) are life‐threatening conditions with high mortality rates, prognostic indicators critical for guiding urgent treatment decisions. We assessed the significance of admission D‐dimer levels in patients AAD AIMH. Methods Results The prospective, multicenter, observational study China recruited participants from 2013 to 2019. Patients AIMH were respectively categorized into quartiles based on levels. Cox...
Background/Aims: Recently, studies have shown that interleukin-37 (IL-37) is involved in atherosclerosis-related diseases. However, the regulatory mechanisms of IL-37 atherosclerosis remain unknown. This study aims to determine role and investigate underlying involved. Methods: expression human atherosclerotic plaques was detected by immunohistochemical staining real-time reverse transcription polymerase chain reaction (RT-PCR). Oil Red O used measure size plaques. Cell apoptosis vitro vivo...
Abstract Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rora fl/fl Il7r Cre/+ mice or induced depletion Icos fl‐DTR‐fl/+ Cd4 expedites AAA growth, increases inflammation, but leads to systemic IL5 eosinophil (EOS) deficiency. Mechanistic studies show that protect from formation via EOS. wild‐type (WT) mice, not Il5 −/− induces EOS differentiation bone‐marrow cells mice. IL5, IL13, WT Il13...
Abstract Aims Blood eosinophil count and cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether how eosinophils ECP contribute to vascular calcification atherogenesis. Methods results Immunostaining revealed accumulation in human mouse atherosclerotic lesions. Eosinophil deficiency ΔdblGATA mice slowed atherogenesis with increased lesion smooth muscle cell (SMC) content reduced calcification. protection was muted when received donor from...
Gob-side entry retaining (GER) employed in a thin coal seam (TCS) can increase economic benefits and recovery, as well mitigate gas concentration the gob. In accordance with caving style of limestone roof, air pressure gob were analyzed, roof-cutting mechanical model GER roadside backfill body (RBB) was proposed, to determine key parameters GER-TCS, including resistance width RBB. The results show that if immediate roof height is greater than height, RBB should meet requirement being totally...
The pH in atherosclerotic lesions varies between individuals. IgE activates macrophage Na
Predicting the drug response of cancer cell lines is crucial for advancing personalized treatment, yet remains challenging due to tumor heterogeneity and individual diversity. In this study, we present a deep learning-based framework named Deep neural network Integrating Prior Knowledge (DIPK) (DIPK), which adopts self-supervised techniques integrate multiple valuable information, including gene interaction relationships, expression profiles molecular topologies, enhance prediction accuracy...
Abstract Aims Blood eosinophil (EOS) counts and EOS cationic protein (ECP) levels associate positively with major cardiovascular disease (CVD) risk factors prevalence. This study investigates the role of in cardiac hypertrophy. Methods results A retrospective cross-section 644 consecutive inpatients hypertension examined association between blood Pressure overload- β-adrenoreceptor agonist isoproterenol-induced hypertrophy was produced EOS-deficient ΔdblGATA mice. revealed positive...
The purpose of this study was to determine the feasibility nondaily image-guided radiotherapy (RT) strategies with intensity-modulated (IMRT) for head and neck cancer.Alignment data analyzed from 103 consecutive patients treated by IMRT cancer who had undergone daily imaging onboard mega-voltage CT (MVCT), resulting in 3275 images. Geometric setup errors that would have occurred using less-than-daily were hypothetically estimated 4 temporal RT protocols.For on first fraction, weekly RT, 5 +...
Intensity-modulated radiotherapy (IMRT) treatment plans generated by segmental multileaf collimator (SMLC) and helical tomotherapy (HT) techniques for patients with nasopharyngeal carcinoma were compared using standardized criteria proposed Radiation Therapy Oncology Group (RTOG) protocol 0225. The goal was to deliver a prescribed dose of 70 Gy at least 95% the planning target volume (PTV) encompassing gross tumor, 59.4 50.4 Gy, respectively, areas high low risk microscopic disease, over 33...
Abstract Aims Group 2 innate lymphoid cells (ILC2s) regulate adaptive and immunities. In mouse heart, production of myocardial infarction (MI) increased ILC2 accumulation, suggesting a role for in cardiac dysfunction post-MI. Methods results We produced MI ILC2-deficeint Rorafl/flIl7rCre/+ mice Icosfl-DTR-fl/+Cd4Cre/+ that allowed diphtheria toxin-induced depletion. Genetic or induced deficiency exacerbated post-MI injury along with accumulation neutrophils, CD11b+Ly6Chi monocytes, CD4+ T...
Abstract Background. To report a single‐institutional experience with the use of helical tomotherapy (HT)‐based intensity‐modulated radiotherapy (IMRT) for head and neck cancer. Methods. Seventy‐seven consecutive patients were treated HT squamous cell carcinoma to median dose 66 Gy (range, 60 72 Gy). Megavoltage CT scans obtained as part an image‐guided registration protocol patient alignment before each treatment. Concurrent chemotherapy was administered 48 (62%). Results. The 2‐year...
Varian has issued two Product Notification Letters warning of known inaccuracies in dwell positions for their GammaMed HDR ring applicator. This inaccuracy was measured sets applicators. Autoexposed radiographs were taken the source at different and analyzed per recommendations using tools within BrachyVision treatment planning program. Comparison between programmed actual showed shifted distally by an average 0.34 cm (0.17 cm-0.59 cm) across all rings. A correction method developed tested....
Tricarboxylic acid cycle (TCA cycle) produces metabolites in the mitochondria under various pathophysiological conditions. Lipopolysaccharide (LPS), Toll-like receptor ligands, or interferons activate macrophages and disrupt TCA cycle. Macrophages then shift to a glycolytic phenotype function declines. These stimuli increase expression of immune-responsive gene-1 (IRG1) that itaconate from cis-aconitate [[1]Degrandi D. Hoffmann R. Beuter-Gunia C. Pfeffer K The proinflammatory...