A5101944347- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Diet, Metabolism, and Disease
- Aortic aneurysm repair treatments
- Mast cells and histamine
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Advanced machining processes and optimization
- Takotsubo Cardiomyopathy and Associated Phenomena
- Liver physiology and pathology
- Abdominal vascular conditions and treatments
- Renin-Angiotensin System Studies
- Cancer Treatment and Pharmacology
- Asthma and respiratory diseases
- Signaling Pathways in Disease
- Liver Diseases and Immunity
- Vascular Tumors and Angiosarcomas
- Salivary Gland Disorders and Functions
- Shape Memory Alloy Transformations
- Renal Diseases and Glomerulopathies
Guangzhou Medical University
2019-2024
Guangzhou First People's Hospital
2019-2024
South China University of Technology
2016-2024
Harvard University
2020-2022
Brigham and Women's Hospital
2019-2022
Kunming Medical University
2017
Second Affiliated Hospital of Kunming Medical College
2017
Southeast Clinical Oncology Research Consortium
2016
Wake Forest University
2016
Clinical studies reveal changes in blood eosinophil counts and cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of or humans mice after myocardial infarction (MI), mostly the infarct region. Genetic inducible depletion eosinophils exacerbates cardiac dysfunction, cell death, fibrosis post-MI, with concurrent acute chronic splenic neutrophils monocytes. Mechanistic roles IL4 protein mEar1 blocking H2O2- hypoxia-induced mouse...
Doxorubicin (DOX) is an antineoplastic drug widely used for the treatment of various types cancer; however, it can induce severe side effects, such as myelosuppression and cardiotoxicity. Sanyang Xuedai (SYKT) a natural medicine originating from ancient prescription Dai nationality in Southwest China. With eight Chinese herbal medicines, including sanguis draconis, radix et rhizoma notoginseng, glycyrrhizae angelicae sinensis primary ingredients, SYKT has been reported to possess numerous...
Abstract White adipose tissue (WAT) plays a role in storing energy, while brown (BAT) is instrumental the re-distribution of stored energy when dietary sources are unavailable. Interleukin-18 (IL18) cytokine playing T-cell polarization, but also for regulating homeostasis via dimeric IL18 receptor (IL18r) and Na-Cl co-transporter (NCC) on adipocytes. Here we show that signaling metabolism regulated at level utilization, with preferential NCC dominantly IL18r WAT. In Il18r −/− Ncc mice,...
Regulatory T cells (Tregs) play essential roles in obesity and diabetes. Here, we report a role of Tregs enhancing β3-adrenergic receptor agonist CL316243 (CL)-stimulated thermogenic program subcutaneous adipose tissue (SAT), but not visceral fat. CL treatment for 7 days increased SAT adipocyte beiging gene expression male or female mice. Adoptive transfer enhanced this activity. Such Treg activity lost epididymal white (eWAT) gonadal gWAT. Adipocyte culture yielded the same conclusion....
Abstract Aims Blood eosinophil (EOS) counts and EOS cationic protein (ECP) levels associate positively with major cardiovascular disease (CVD) risk factors prevalence. This study investigates the role of in cardiac hypertrophy. Methods results A retrospective cross-section 644 consecutive inpatients hypertension examined association between blood Pressure overload- β-adrenoreceptor agonist isoproterenol-induced hypertrophy was produced EOS-deficient ΔdblGATA mice. revealed positive...
Hepatic apolipoprotein A-IV (apoA-IV) expression is correlated with hepatic triglyceride (TG) content in mouse models of chronic hepatosteatosis, and steatosis-induced apoA-IV gene regulated by nuclear transcription factor cAMP-responsive element-binding protein H (CREBH) processing. To define what aspects TG homeostasis regulate CREBH processing expression, several attenuated VLDL particle assembly were subjected to acute hepatosteatosis induced an overnight fast or short term ketogenic...
Allergic asthma with high plasma IgE levels is a significant risk factor of human abdominal aortic aneurysm (AAA). This study tests direct role in angiotensin-II (Ang-II) perfusion- and peri-aortic CaCl2 injury-induced AAA mice. In both models, IgE-deficiency Apoe-/- Ige-/- mice blunts growth reduces lesion accumulation macrophages, CD4+ CD8+ T cells, MHC class-II expression, CD31+ microvessel growth, media smooth muscle cell loss, compared those from control Real time-PCR reveals reductions...
IgE-mediated activation of Nhe1 (Na+-H+ exchanger-1) induces aortic cell extracellular acidification and promotes apoptosis. A pH-sensitive probe pHrodo identified acidic regions at positions macrophage accumulation, IgE expression, apoptosis in human mouse abdominal aneurysm (AAA) lesions. Ang II (angiotensin II)-induced AAA Nhe1-insufficient Apoe-/-Nhe1+/- mice Apoe-/-Nhe1+/+ littermates tested activity experimental AAA, because Nhe1-/- develop ataxia epileptic-like seizures die early....
We aim to investigate cardiovascular mortality risk among diffuse large B-cell lymphoma (DLBCL) patients and explore trends in the past decades United States. extracted data from Surveillance, Epidemiology, End Results database for adult diagnosed with DLBCL between 1975 2019. Standardized ratio, joinpoint regression analysis, competing model were analyzed. Overall, 49,918 enrolled, of whom 4167 (8.3%) deaths observed, which was 1.22 times number expected (95%CI, 1.19–1.26). During...
Background: Our previous studies have demonstrated that hepatic expression of apolipoprotein A-IV (apoA-IV) is increased in mouse models chronic steatosis and closely correlated with triglyceride (TG) content. We also shown steatosis-induced apoA-IV gene regulated by processing the nuclear transcription factor cAMP responsive element-binding protein H (CREBH). Herein, we explored mechanisms mediate CREBH processing. Methods: measured processing, expression, lipid content several attenuated...
Objective To determine the expression of plasmacytoid dendritic cells and interferon-gama (IFN-γ) in labial gland tissue patients with primary Sjogren′s syndrome (pSS) to investigate role pDC pathogenesis pSS their significance. Methods Gland samples were collected from 39 19 dry mouth who did not meet diagnostic criteria for pSS. IFN-γ determined by fluorescent antibody technique assess association between lymphocyte focal index as well clinical indexes patients. The difference two...
Background: Clinic studies and experimental models demonstrate that cardiac hypertrophy involves cell apoptosis, fibrosis, immune interactions. Eosinophil (EOS) is a prominent type in host response by releasing cationic proteins anti-inflammatory cytokines. Methods: To test the direct role of EOS hypertrophy, transverse aortic constriction (TAC) surgery was performed both eosinophil-deficient ΔdblGATA mice wild-type (WT) control mice. Adoptive transfer from WT or interleukin-4...