A5101735369- Cancer therapeutics and mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Synthesis and biological activity
- Lung Cancer Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- RNA modifications and cancer
- COVID-19 diagnosis using AI
- Quinazolinone synthesis and applications
- Traditional Chinese Medicine Analysis
- Click Chemistry and Applications
- AI in cancer detection
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Acute Myeloid Leukemia Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Galectins and Cancer Biology
- Effects and risks of endocrine disrupting chemicals
- Natural product bioactivities and synthesis
- Infections and bacterial resistance
- Synthesis of Organic Compounds
- Ginseng Biological Effects and Applications
- Organic and Inorganic Chemical Reactions
Shandong University of Traditional Chinese Medicine
2019-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2019-2024
Jishan County People's Hospital
2024
First Hospital of Jiaxing
2024
Tianjin University
2021-2022
Shandong University
2009-2018
University of Washington
1999
The epithelial-mesenchymal transition (EMT) serves vital roles in the angiogenesis, cell invasion and metastasis of various malignant tumors, including bladder cancer. Traditional Chinese medicinal herbs have been demonstrated to exhibit anticancer properties. present study aimed screen sensitivity cancer natural compounds by using six classic anti-inflammatory detoxifying herbs, ethanol extract Paris polyphylla (PPE), Scutellaria barbata, Pulsatillae decoction, Dahuang Huanglian Xiexin...
Zinc oxide nanoparticles (ZnO NPs) have exhibited excellent anti-tumor properties; the present study aimed to elucidate underlying mechanism of ZnO NPs induced apoptosis in acute myeloid leukemia (AML) cells by regulating mitochondrial division. THP-1 cells, an AML cell line, were first incubated with different concentrations for 24 hr. Next, expression Drp-1, Bcl-2, Bax mRNA, and protein was detected, effects on levels reactive oxygen species (ROS), membrane potential (Δψm), apoptosis, ATP...
Polyphyllin I has been reported to possess anticancer properties in various cancer types, including prostate cancer. However, little is known about the potential of induction cell cycle arrest and its underlying mechanisms.The anti-proliferation activity was tested using counting kit-8 assay. The effects were confirmed by flow cytometry. Western blot used test effect on cycle-related protein expression. Reverse transcription-polymerase chain reaction expression genes regulating P21...
Taking the previously discovered 1-methyl-1,4-dihydroindeno[1,2c]pyrazol derivative LL01 as a lead, systematic structural modifications were made at phenolic 6- and 7-positions aniline 3-position of indenopyrazole core to investigate SARs improve water solubility. Among designed indenopyrazoles ID01–ID33, series potent MTAs identified. As hydrochloride salt(s), ID09 ID33 showed excellent aqueous solubility favorable Log P value displayed noteworthily low nanomolar potency against variety...
Background: Coumarins possess a broad spectrum of biological activities and are important pharmacophores in drug developments. Since aberrant upregulation PI3K/Akt signaling is related to uncontrolled tumor cell proliferation, enhanced migration, adhesion-independent growth, it interests find novel coumarin derivatives as anticancer agents targeting the pathway. Keywords: Anticancer agents, apoptosis, coumarins, Friedel-Crafts alkylation, inhibitors, Pechman reaction, PI3K, signal
Hepatocellular carcinoma (HCC) is one of the most malignant tumors with persistently high morbidity and mortality. However, expression, prognostic clinical significance FAM189 family genes in HCC remain largely unknown. In this study, expression levels were analyzed through TCGA-LIHC ICGC-LIRI-JP cohorts, further validated multiple independent GEO datasets. It was found that FAM189B significantly upregulated tumor tissues, while FAM189A1 FAM189A2 not changed between adjacent tissues. Further...
Lung cancer is one of the deadliest diseases in which adenocarcinoma account for nearly 40%. To make an effective treatment and diagnosis, it vital to accurately discriminate invasive (IA) from non-IA by analyzing ground glass nodules (GGNs) patient's CT images. Compared with solid normal lung parenchyma, contours GGN are blurred gray scale little changed. So far, problem IA remains unsolved due insufficient labeled In this paper, considering generalization convolutional neural network (CNN)...
Repair of DNA double-strand breaks (DSBs) is critical for the maintenance genome integrity, cell survival, and prevention tumorigenesis. Three pathways are responsible repair DSBs: homologous recombination (HR), single strand annealing (SSA) non-homologous end joining (NHEJ). DNA-dependent Protein Kinase (DNA-PK), key component NHEJ pathway, becomes an important target cancer therapy. A large number small molecules exhibit inhibitory activities against DNA-PK in ATP-competitive manner. This...
Background: Paris polyphylla is a traditional Chinese medicinal herb with multiple antitumor activities, but the role of P. in bladder cancer (BC) under investigation. This study aims to examine activities ethanol extract (PPE) on BC cells and elucidate underlying mechanisms. Methods: Viable were counted using trypan blue exclusion assay. The cell cycle was analyzed flow cytometry, scratch wound-healing transwell assays used evaluate migration invasion abilities, respectively. protein...
The apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G) converts cytosine to uracil in DNA/RNA. Its role resisting viral invasion has been well documented. However, its expression pattern and potential function AML remain unclear. In this study, we carried out a bioinformatics analysis revealed that the of APOBEC3G was significantly upregulated AML, high associated with short overall survival (OS). especially increased non-M3AML, correlated unfavorable cytogenetic risks....
Exploring effective combination antibacterial therapies has become a research focus. This study selected seven common antibiotics to perform series of tests on different Gram-negative bacteria isolated from clinical samples chronic obstructive pulmonary disease patients. More than 70% the strains exhibited multi-drug resistance but remained sensitive polymyxin B. The checkerboard assay revealed significant synergistic effect between B and tetracycline against resistant strains, with...
Statistical Learning Theory (SLT) plays an important role in prediction estimation and machine learning when only limited samples are available. At present, determining how many necessary under given circumstances for accuracy is still unknown. In this paper, the medical diagnosis on lung cancer taken as example to solve problem. Invasive adenocarcinoma (IA) a main type of cancer, often presented ground glass nodules (GGNs) patient’s CT images. Accurately discriminating IA from non-IA based...