A5103195305- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Heavy Metal Exposure and Toxicity
- Inflammatory Myopathies and Dermatomyositis
- Heavy metals in environment
- Rheumatoid Arthritis Research and Therapies
- Trace Elements in Health
- Adrenal Hormones and Disorders
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Polysaccharides and Plant Cell Walls
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Immunotoxicology and immune responses
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Celiac Disease Research and Management
- Histone Deacetylase Inhibitors Research
- Gastrointestinal motility and disorders
- Nutritional Studies and Diet
- Nuts composition and effects
Peking University
2020-2024
Peking University People's Hospital
2020-2024
Second Affiliated Hospital of Nanchang University
2018
Nanchang University
2018
Huashan Hospital
2012-2014
Fudan University
2004-2014
The imbalance between pathogenic and beneficial species of the intestinal microbiome metabolism in rheumatoid arthritis (RA) remains unclarified. Here, using shotgun-based metagenome sequencing for a treatment-naïve patient cohort “quasi-paired cohort” method, we observed deficiency butyrate-producing an overwhelming number butyrate consumers RA patients. These outcomes mainly occurred patients with positive ACPA, mean AUC 0.94. This panel was also validated established 0.986 those joint...
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, no efficient therapy. There need to study potential therapeutic approaches.To investigate the efficacy, safety, and response of low-dose interleukin 2 (LD-IL-2) in treatment pSS.A double-blind, placebo-controlled randomized clinical trial was conducted 2-group superiority design from June 2015 August 2017. Sixty patients, aged 18 70 years, were recruited Peking University People's...
Abstract Objective To investigate the regulation of T follicular regulatory (Tfr) and (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) a randomized, double-blind, placebo-controlled clinical trial. Methods A post hoc analysis was performed randomized cohort SLE patients (n=60) receiving therapy (n=30) or placebo (n=30), along with standard care treatment. The primary endpoint attainment responder index-4 (SRI-4) at week 12 Twenty-three healthy controls were enrolled...
The microbiota has been observed altered in autoimmune diseases, including idiopathic inflammatory myopathies (IIMs), and associated with different treatments. Low-dose IL-2 treatment emerges as a new option for active IIMs. This study aims to explore the role of low-dose regulating intestinal dysbiosis involved In this study, 13 patients IIMs were enrolled received 1 ×10 6 IU subcutaneously every other day 12 weeks plus standard care. clinical response immune assessed. Stool samples...
It has been reported that anti-metallothionein (a metallothionein antibody) is present in the circulation of healthy subjects and patients suffering from atopic dermatitis. The aim this study was to investigate whether cadmium-induced renal dysfunction related presence plasma antibody (MT-Ab) workers exposed cadmium (Cd) occupationally. Plasma determined by enzyme linked immunosorbent assay (ELISA) techniques, both exposure assessment risk were conducted cadmium-exposed China. We demonstrate...
Treatment of idiopathic inflammatory myopathies (IIMs) is challenging due to a lack safe and efficacious medication. Low-dose interleukin-2 (IL-2) treatment emerges as new option in active IIMs. This study aims explore the clinical immunological effects low-dose IL-2 patients with Eighteen IIMs were enrolled received 1 × 106 IU subcutaneously every other day for 12 weeks on top standard care. The primary endpoint trial was change percentage regulatory T (Treg) cells total CD4+ at week 12....
Scope This study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjögren's syndrome (pSS). Methods results Non‐obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg −1 d ), high (10 low interleukin (IL)‐2 (25 000 IU/d), control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces salivary gland inflammation compared with group (histological score p vs Control...
Objective To investigate the clinical characteristics, diagnostic approaches, short-term efficacy of treatment and prognosis lymphoma patients presenting with a fever unknown origin (FUO). Methods We reviewed records 132 finally diagnosed in Huashan Hospital, half whom initially presented FUO. The other 66 without history FUO were within month when several group also diagnosed. Results predominantly young men (71.21%, p=0.35) characterized by temperature ≥39°C (55/66, 83.33%). Compared...
Abstract Objectives Low-dose interleukin 2 (Ld-IL2) is increasingly being explored as an immune-modulating treatment for autoimmune diseases which mainly affect T cell subsets. This study investigates the metabolic effects of Ld-IL2 therapy in patients with primary Sjögren’s syndrome (pSS). Method A total 60 were recruited to conduct a double-blind, randomized clinical trial. Of these patients, 50% (30/60) received along standard 12 weeks, followed by weeks follow-up. The effectiveness was...
Objectives Lupus fundus abnormalities are a sight-threatening complication of systemic lupus erythematosus (SLE) and its pathogenesis remains to be studied. The aim this study was assess the clinical characteristics associated with presence anti-recoverin antibodies in patients SLE, especially those abnormalities. Methods Seventy-six participants were enrolled, including 21 (fundus group), 30 without (non-fundus group) 25 healthy individuals. Serum antibody levels measured using...
Myeloid sarcoma (MS) is a rare disease that presents as an extramedullary tumorous mass of immature myeloid precursors. The majority MS are identified in acute leukemia (AML) patients and rarely present primary isolated without AML. In addition, inversion chromosome 16 [inv(16)] the CBFβ/MYH11 fusion gene associated with MS. current study reports female patient duodenal MS, who developed AML-M4 48,XX,inv(16),+13,+22. A review previously reported cases was also performed. Isolated often...
Sjögren’s syndrome (SS) is a systemic autoimmune disease with no efficient treatment, and it associated dysregulated immune cells impaired interleukin (IL)-2 signaling. IL-2 critical for the development maintenance of Treg cells. The use low dose (LDIL-2) in treatment diseases promising, but efficacy mechanism SS therapy are still to be confirmed. This study aims investigate therapeutic effect LDIL-2 on NOD (non-obese diabetic) mice. mice (female, 8 weeks old) were randomly assigned into...
Introduction Low-dose interleukin-2 (IL-2) regulates the homeostasis of CD4+ T cells by modulating proportions effector and regulatory cells, thus reducing disease activity in patients with systemic lupus erythematosus (SLE). However, to date, no research has been carried out on efficacy low-dose IL-2 for treating autoimmune thyroid (AITD). The aim this study was observe effects AITD concurrent SLE, explore potential mechanism action.
Hypomyopathic dermatomyositis (DM) presents with cutaneous lesions consistent but in the absence of clinically appreciable muscle weakness. The manifestations are often refractory and more resistant to conventional therapy than concomitant involvement. We present a 61-year-old hypomyopathic patient DM who failed respond standard was successfully treated by low-dose interleukin-2 (IL-2) no significant side effects. conclude that IL-2 is safe effective treatment for DM.
Low-dose IL-2 (Ld-IL2) has shown favorable therapeutic effects in systemic lupus erythematosus (SLE) therapy. However, previous clinical trials reported an SLE Responder Index-4 (SRI-4) response rate of 65.52%-68%, with approximately half failing to achieve the primary endpoint by week 24. Our study aims determine real-world use Ld-IL2 and identify determinants its effectiveness SLE.
<title>Abstract</title> Behçet’s syndrome (BS), a chronic relapsing systemic vasculitis, leads to recurrent oral aphthous ulcers, severely impacting quality of life. We conducted randomized double-blind placebo-controlled clinical trial evaluate the efficacy and safety Low-dose interleukin-2 (LD-IL-2) in BS patients. randomly assigned patients (aged 18 70 years) with active ulcers receive LD-IL-2 or placebo for 12 weeks (1:1 ratio). The primary endpoint was ulcer count at week 12. Secondary...
Given increased acceptance of the CoronaVac, there is an unmet need to assess safety and immunogenic changes CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral cellular responses patient RD after a three-dose immunization regimen CoronaVac. stable condition and/or low disease activity (n = 40) or healthy controls were assigned 1:1 ratio receive (Sinovac). The prevalence anti-receptor binding domain (RBD) antibodies neutralizing was similar between...
Abstract Background Recently, the designation "Metabolic Associated Fatty Liver Disease" (MAFLD) has emerged to more holistically depict disease's multifaceted nature. Within this framework, patients are stratified as either metabolically healthy (MH) or unhealthy (MU). The unique nutrient composition of nuts and seeds (NUTSDS) suggests potential health advantages, potentially mitigating premature mortality risks.This research delves into impact NUTSDS consumption on all-cause within diverse...