A5042782950- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Muscle and Compartmental Disorders
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Chemokine receptors and signaling
- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myasthenia Gravis and Thymoma
- Autoimmune Bullous Skin Diseases
- interferon and immune responses
- Gout, Hyperuricemia, Uric Acid
- Cytomegalovirus and herpesvirus research
Peking University Shougang Hospital
2023-2025
Peking University
2015-2024
Peking University People's Hospital
2013-2024
Peking University International Hospital
2016-2023
Second People’s Hospital of Yibin
2023
Sichuan University
2015-2017
West China Second University Hospital of Sichuan University
2017
West China Hospital of Sichuan University
2015
TU Dortmund University
2014
University of Bonn
2014
The imbalance between pathogenic and beneficial species of the intestinal microbiome metabolism in rheumatoid arthritis (RA) remains unclarified. Here, using shotgun-based metagenome sequencing for a treatment-naïve patient cohort “quasi-paired cohort” method, we observed deficiency butyrate-producing an overwhelming number butyrate consumers RA patients. These outcomes mainly occurred patients with positive ACPA, mean AUC 0.94. This panel was also validated established 0.986 those joint...
<h3>Objectives</h3> Although myeloid-derived suppressor cells (MDSCs) have been linked to T cell tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we investigate the potential association of MDSCs with disease pathogenesis using a preclinical model RA and specimen collected from patients RA. <h3>Methods</h3> The frequency blood, lymphoid tissues, inflamed paws or synovial fluid severity, tissue inflammation levels pathogenic helper (Th) 17 were examined...
<h3>Objectives</h3> Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact on TLR-induced inflammation The aim this study was to reveal effects its regulator, hypoxia-inducible factor-1α (HIF-1α), inflammatory response RA fibroblasts (RASF) TLR ligands. <h3>Methods</h3> Hypoxia induced RASF by...
B10 and B10pro cells suppress immune responses via secreting interleukin (IL)-10. However, their regulators underlying mechanisms, especially in human autoimmune diseases, are elusive. This study aimed to address these questions rheumatoid arthritis (RA), one of the most common highly disabling diseases.
Synovial fibroblast hyperplasia, T-cell hyperactivity, B-cell overactivation, and the self-perpetuating interactions among these cell types are major characteristics of rheumatoid arthritis (RA). The inflamed joints RA patients hypoxic, with upregulated expression hypoxia-inducible factor-1α (HIF-1α) in synovial fibroblasts (RASFs). It remains unknown whether HIF-1α regulates between RASFs T cells B cells. We report here that promotes inflammatory cytokines IL-6, IL-8, TNF-α, IL-1β,...
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone cartilage erosion. Synovial fibroblast- T cell-mediated inflammation plays crucial roles in the pathogenesis of RA. However how this initiated, propagated, maintained remains controversial. Here, we systemically examined contribution toll-like receptors (TLRs) to mediator production as well Th1 Th17 cell hyperactivity Our results show that rheumatoid fibroblasts (RASF)...
Background: The roles that CD16+ monocyte subset plays in T-cell activation and B-cell response have not been well studied systemic lupus erythematosus (SLE). Objective: present study aimed to investigate the distribution of subsets SLE explore their possible differentiation. Methods: frequencies peripheral blood healthy controls (HCs) patients with were determined by flow cytometry. Monocyte sorted co-cultured CD4+ T cells CD19+ B cells. Then, collected for different detection, while...
Alterations in intestinal microbiota have been identified as a key risk factor rheumatoid arthritis (RA). This study presents multidimensional gut profile from large cohort of RA patients, stratified by disease stage and treatment regimens, compared to healthy controls. Our dataset comprises profiles 2,238 individuals, including 1,034 patients (Ascia Pacific cohort, APRAC) 1,204 is enriched with detailed clinical metadata, patient profiles, histories, environmental factors, providing...
Abstract Objective This study aimed to evaluate the utility of ANCA specificity as a primary criterion for classifying AAV subtypes simplify diagnostic process without compromising accuracy. Methods A retrospective cohort was conducted involving 310 patients diagnosed with between January 2015 and December 2023 across three tertiary care centers affiliated Peking University. Patients were reclassified using methods: European Medicines Agency (EMA) algorithm, 2022 American College...
Hyperplasia of synovial fibroblasts, infiltration with inflammatory cytokines, and tissue hypoxia are the major characteristics rheumatoid arthritis (RA). Interleukin 33 (IL-33) is a newly identified cytokine exacerbating disease severity RA. Hypoxia-inducible factor-1α (HIF-1α) showed increased expression in RA synovium could regulate number productions. Nevertheless, its correlation IL-33 remains largely unknown. Here, we that elevated levels were demonstrated patient fluids, upregulated...
Natural antibodies, particularly natural IgM, are proved to play indispensable roles in the immune defenses against common infections. More recently, protective of these IgM were also recognized autoimmune diseases. They mainly produced by B-1 and innate-like B cells (ILBs). Human CD19+CD27+IgD+ cells, termed as un-switched memory proposed be a kind ILBs. However, functional features characteristics rheumatoid arthritis (RA) remained poorly understood. In this study, we found that human...
IgG glycosylation differs in rheumatoid arthritis (RA) and osteoarthritis (OA), which should contribute to their pathogenesis research diagnosis.
Objective . To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages soluble (sMer) levels in plasma systemic lupus erythematosus (SLE). Method 108 SLE patients 42 healthy controls were recruited this study. The mMer surfaces was evaluated by flow cytometry (FCM). sMer measured ELISA. Real-time quantitative PCR applied to evaluate mRNA ADAM17. Results Both significantly increased compared subjects. frequency...
Axl is one of the TAM family members that downregulates activated immune responses to maintain homeostasis. We analyzed expression and clinical relevance on surface CD14+ monocytes/macrophages (mAxl, membrane Axl) in plasma (sAxl, soluble from patients with systemic lupus erythematosus (SLE). Compared healthy subjects, concentrations sAxl were significantly elevated SLE patients, while mAxl was downregulated. A series severe disease manifestations laboratory features such as presence...
Summary The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of kinases, the role which in autoimmune diseases such as systemic lupus erythematosus has been well explored, while their functions rheumatoid arthritis (RA) remain largely unknown. In this study, we investigated soluble (sAxl/sMer/sTyro3) patients with RA. A total 306 RA patients, 100 osteoarthritis (OA) and 120 healthy controls (HCs) were enrolled into study. serum concentrations sAxl/sMer/sTyro3 measured by enzyme-linked...
Abstract Aim The aim of this study was to identify the risk factors and prognosis patients with cancer‐associated myositis (CAM). Method Four hundred eighty‐seven dermatomyositis (DM), clinical amyopathic (CADM) polymyositis (PM) from 3 centers were enrolled retrospectively in study. Clinical laboratory data CAM non‐CAM compared. Logistic regression analysis used CAM. Results Out 487 DM/CADM/PM, 7.0% (34/487) classified as Older age (53.91 ± 13.32 vs. 48.76 14.34 years), heliotrope rash...
Background: Rapidly progressive interstitial lung disease (RP-ILD) is a fatal complication of dermatomyositis (DM) and clinically amyopathic DM (CADM). The objective this study was to evaluate risk markers associated with RP-ILD incidence in patients DM/CADM develop prediction (RRP) model. Methods: clinical records 229 from Peking University People's Hospital, 97 four other independent centers were retrospectively reviewed. Univariate multivariate logistic regression analyses performed...
Background: Clinical remission is the treatment target in rheumatoid arthritis (RA). This study aimed to investigate clinical and related factors a large cohort of patients with RA. Methods: composed 342 Data were collected by face-to-face interview 1049 RA who visited Department Rheumatology three teaching hospitals from September 2015 May 2016. The clinically assessed rheumatologists four-page questionnaire was completed on site. Subsequently, fulfilled criteria further analyzed....
Viruses have been considered as important participants in the development of rheumatoid arthritis (RA). However, profile enteric virome and its role RA remains elusive. This study aimed to investigate atlas involvement pathogenesis.