A5101470660- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- X-ray Diffraction in Crystallography
- Ginseng Biological Effects and Applications
- Crystallization and Solubility Studies
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Sleep and related disorders
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Sleep and Wakefulness Research
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Immune Cell Function and Interaction
- Medicinal Plant Pharmacodynamics Research
- Immune cells in cancer
- Toxin Mechanisms and Immunotoxins
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Animal testing and alternatives
China Three Gorges University
2017-2024
National Center of Ocean Standards and Metrology
2024
Changchun University of Chinese Medicine
2021
Dalian University of Technology
2019-2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Weatherford College
2021
Foshan Second People's Hospital
2020
Jinan University
2016-2019
Shenzhen Zhongshan Urological Hospital
2019
MEI Research (United States)
2019
<h3>Objectives</h3> Although myeloid-derived suppressor cells (MDSCs) have been linked to T cell tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we investigate the potential association of MDSCs with disease pathogenesis using a preclinical model RA and specimen collected from patients RA. <h3>Methods</h3> The frequency blood, lymphoid tissues, inflamed paws or synovial fluid severity, tissue inflammation levels pathogenic helper (Th) 17 were examined...
Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates activation of through coordinated phosphorylation ULK1. In this study, we investigated mechanisms underlying neuroprotective effect puerarin its role in modulating via AMPK-mTOR-ULK1 rat middle artery occlusion model injury. Rats were intraperitoneally injected with puerarin, 50 or 100 mg/kg, daily for 7 days. Then, 30 minutes...
Cerebral ischemia/reperfusion (CIR) injury occurs when blood flow is restored in the brain, causing secondary damage to ischemic tissues. Previous studies have shown that electroacupuncture (EA) treatment contributes brain protection against CIR through modulating autophagy. Studies indicated SIRT1-FOXO1 plays a crucial role regulating Here we investigated mechanisms underlying neuroprotective effect of EA and its autophagy via signaling pathway rats with injury. pretreatment at "Baihui",...
Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of ischemic stroke. Flavonoids are broad family plant polyphenols which abundant in traditional Chinese medicine (TCM) and have beneficial effects on several diseases including Accumulating studies indicated that flavonoids derived from herbal TCM effective alleviating CIRI after stroke vitro or vivo , exhibit favourable therapeutical potential. Herein, we systematically review the classification, metabolic...
The objective of the present study is to investigate inhibitory effects sinomenine (SIN) on angiogenesis in a collagen-induced arthritis (CIA) mouse model. Arthritis assessments for all mice were recorded. histopathological performed following haematoxylin and eosin (HE) staining. Immunohistochemistry enzyme-linked immunosorbent assay (ELISA) analyses used detect expression hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) angiopoietin 1 (ANG-1) serum membrane....
To explore the potential targets underlying effect of sinomenine (SIN) on rheumatoid arthritis (RA) by utilizing a network pharmacology approach.SIN and its drug were identified using analysis followed experimental validation. First, Pharmmapper, UniProt GeneCards databases mined for information relevant to prediction SIN RA-related targets. Second, SIN-target gene SIN-RA target networks created in Cytoscape software collection candidate each component R software. Eventually, key enriched...
To determine the role of natural killer (NK)-22 cells in pathogenesis rheumatoid arthritis (RA).Using flow cytometry, proportions NK-22 and intracellular contents perforin, granzyme B, interferon-γ (IFN-γ) were determined peripheral blood (PB) synovial fluid (SF) patients with RA healthy individuals. The levels interleukin 22 (IL-22) tumor necrosis factor-α (TNF-α) supernatant gene expressions measured using ELISA QuantiGene Plex assay, respectively. effect on proliferation fibroblast-like...
Rheumatoid arthritis (RA) is a common autoimmune disease, for which no economical and safe target drug treatment available. Chikusetsusaponin Ⅳa (CS-IVa), an active compound in Panax japonicus C.A. Mey, has good anti-inflammatory effect, but whether this can serve as targeted RA the corresponding therapeutic mechanism remain unclear.To investigate bone-protecting effects of CS-IVa on possible mechanisms action.Biomarkers underlying pathological were examined by performing bioinformatics...
Background: Cerebral ischemia-reperfusion injury (CIRI) is a crucial factor leading to poor prognosis for ischemic stroke patients. As novel Chinese medicine formula, Naotaifang (NTF) was proven exhibit neuroprotective effect against stroke, clinically, and alleviate CIRI in animals. However, the mechanisms underlying beneficial have not been fully elucidated. Methods: In this study, we combined network pharmacology approach an vivo experiment explore specific effects of NTF treatment...
Traditional Chinese herbal medicine Panax japonicus C.A. Meyer has a long history in clinical treatment of rheumatoid arthritis (RA). Total saponins (TSPJs) were extracted from the root Meyer, and its anti-rheumatism mechanism is still unclear.
Abstract Objectives While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, potential impact of the MDSC-Th17 immune axis on abnormal bone destruction RA remains largely unknown. Methods We investigated correlation between frequency MDSCs or its subsets and joint patients. The reciprocal actions patient-derived Th17 studied using osteoclast (OC) differentiation resorption assays vitro, which further...
Geum japonicum Tunb. var. chinense (GJ) is a traditional Chinese medicine usually used for the alleviation of dizziness and headache. Previous studies have reported that GJ extracts could alleviate cerebral I/R injury by reducing apoptosis in vivo. To further elucidate positive role underlying mechanism injury, current study investigated effects on oxygen-glucose deprivation re-oxygenation (OGD/R)-induced astrocytes light BDNF/PI3K/Akt/CREB signaling pathway with seropharmacological method....
The objective of the present study is to evaluate inhibitory effects taxol (PTX) on angiogenesis in a collagen-induced arthritis (CIA) mouse model. Collagen II (C II) and complete Freund's adjuvant (CFA) were used C57BL/6 (H-2b) mice generate CIA Random grouping was performed normal control group, model PTX 1.5 mg/kg 1.0 0.5 group. Arthritis index scores, tissue pathology synovium microvessel density (MVD) analysis performed. Immunohistochemistry enzyme-linked immunosorbent assay detect...
Although CD3-CD56+NKp44+ natural killer (NKp44+NK) cells have been linked to autoimmune diseases including inflammatory bowel disease, ankylosing spondylitis, and primary Sjogren syndrome, the expansion role of those in patients with rheumatoid arthritis (RA) remain less defined. Here, we investigate proportion pathogenesis NKp44+NK RA. The results show significantly expanded RA peripheral blood synovial fluid, which were correlated positively disease activity. They also highly expressed...