A5067829440- Inflammatory Myopathies and Dermatomyositis
- Heterotopic Ossification and Related Conditions
- IgG4-Related and Inflammatory Diseases
- T-cell and B-cell Immunology
- Gut microbiota and health
- Inflammatory Bowel Disease
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Pancreatitis Pathology and Treatment
- Microscopic Colitis
- Spondyloarthritis Studies and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Orthopedic Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Salivary Gland Disorders and Functions
- Rheumatoid Arthritis Research and Therapies
Peking University
2021-2024
Peking University People's Hospital
2021-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
The imbalance between pathogenic and beneficial species of the intestinal microbiome metabolism in rheumatoid arthritis (RA) remains unclarified. Here, using shotgun-based metagenome sequencing for a treatment-naïve patient cohort “quasi-paired cohort” method, we observed deficiency butyrate-producing an overwhelming number butyrate consumers RA patients. These outcomes mainly occurred patients with positive ACPA, mean AUC 0.94. This panel was also validated established 0.986 those joint...
Abstract Objective To investigate the regulation of T follicular regulatory (Tfr) and (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) a randomized, double-blind, placebo-controlled clinical trial. Methods A post hoc analysis was performed randomized cohort SLE patients (n=60) receiving therapy (n=30) or placebo (n=30), along with standard care treatment. The primary endpoint attainment responder index-4 (SRI-4) at week 12 Twenty-three healthy controls were enrolled...
The microbiota has been observed altered in autoimmune diseases, including idiopathic inflammatory myopathies (IIMs), and associated with different treatments. Low-dose IL-2 treatment emerges as a new option for active IIMs. This study aims to explore the role of low-dose regulating intestinal dysbiosis involved In this study, 13 patients IIMs were enrolled received 1 ×10 6 IU subcutaneously every other day 12 weeks plus standard care. clinical response immune assessed. Stool samples...
Objective The purpose of this research was to ascertain the effectiveness newly established criteria for classifying IgG4-related disease (IgG4-RD), as applied a large Chinese cohort in real-world clinical settings. Methods Patient data were procured from digital health records 4 prominent academic hospitals. criterion standard identifying IgG4-RD patients seasoned rheumatologist. control group consisted individuals with other ailments such cancer, forms pancreatitis, infectious diseases,...
<title>Abstract</title> It is unknown if dysbiosis of microbiota plays a role in the initiation and severity rheumatoid arthritis (RA). In comprehensive study 2297 individuals, including 1,064 RA patients 1,233 healthy controls, we uncovered an age-related trajectory fluctuation intestinal which clearly coincided with peak age onset. Patients at onset exhibited significant reduction anti-inflammatory species like<italic>Akkermansia muciniphila</italic>,<italic>Butyrivibrio...
Abstract Objective The clinical relevance and pathogenic role of gut microbiome in both myositis its associated interstitial lung disease (ILD) are still unclear. purpose this study was to investigate the through comprehensive metagenomic-wide association studies (MWAS). Methods We conducted MWAS a Chinese cohort by using whole-genome shotgun sequencing high depth, including 30 patients 31 healthy controls (HC). Among patients, 11 developed rapidly progressive (RP-ILD) 10 had chronic ILD...
<title>Abstract</title> <bold>Background:</bold> The clinical relevance and pathogenic role of gut microbiome in both myositis its associated interstitial lung disease (ILD) are still unclear.The purpose this study was to investigate the through comprehensive metagenomic-wide association studies (MWAS).<bold>Results</bold> We conducted MWAS a Chinese cohort by using whole-genome shotgun sequencing high depth, including 30 patients 31 healthy controls (HC). Among patients, 11 developed...
Abstract Objective: To investigate the regulation of T follicular regulatory (Tfr) and (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) a randomized, double-blind, placebo-controlled clinical trial. Methods: A post-hoc analysis was performed randomized cohort SLE patients (n=60) receiving therapy (n=30) or placebo (n=30), along with standard care treatment. The primary end point attainment responder index-4 (SRI-4) at week 12 Twenty three healthy controls were...