A5101384651- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Genetic and rare skin diseases.
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- IgG4-Related and Inflammatory Diseases
- Signaling Pathways in Disease
- Spondyloarthritis Studies and Treatments
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Dermatologic Treatments and Research
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Hair Growth and Disorders
- Mosquito-borne diseases and control
- Gastrointestinal disorders and treatments
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Guangdong Pharmaceutical University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2023-2024
Abstract Alopecia is a commonly encountered condition primarily induced by multiple factors involving psychological and environmental changes. It often accompanied persistent oxidative stress apoptosis of dermal papilla cells (DPCs), which induce disabilities in hair growth induction. Existing clinical approaches aim at symptom treatment or recurrence reduction, their efficacy unsatisfactory. Cold atmospheric plasma (CAP) possesses potent antioxidant properties ability to promote cell...
Abstract Disulfidptosis is a recently identified mode of regulated cell death. Regulating disulfidptosis in carcinoma promising therapeutic approach. Long non-coding RNAs (lncRNAs) have been reported to be related the occurrence and development many cancers. Disulfidptosis-related lncRNAs (DRLs) HPV-negative oral squamous (OSCC) not studied. Based on The Cancer Genome Atlas (TCGA) database, least absolute shrinkage selection operator (LASSO) analysis Cox regression were used identify overall...
Background: To investigate factors associated with COVID-19 infection, hospital admission and disease relapse in patients IgG4-related (IgG4-RD).Methods: Physician-reported IgG4-RD were included this retrospective study. Using multivariable logistic regression analysis to determine for primary outcome (COVID-19-related relapse) secondary (COVID-19 infection admission). Covariates age, sex, body mass index, smoking status, comorbidities, clinical features treatment strategies.Results: Among...
Background Hailey–Hailey disease (HHD) is a rare, autosomal dominant, hereditary skin disorder characterised by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 ( ATP2C1 ) encodes the protein secretory pathway Ca 2+ ATPase1 (SPCA1), playing critical role in HHD pathogenesis. Aims We aimed to investigate effect of knockdown on keratinocytes that mimicked acantholysis HHD. Methods Immunohistochemistry (IHC) was employed evaluate levels cytoskeletal...
Abstract Background The existing body of literature is deficient in the most recent data regarding global perspective dengue fever and its associated health inequities.Our aim to assess burden inequities from 1990 2021. Methods We utilized Global Burden Disease (GBD) database for epidemiological trends, demographic analysis, decomposition. Cross-national inequality predictive modeling up 2051 were also performed. Results Globally, incidence, prevalence, DALYs, mortality showed increasing...
Abstract Foot ulcers are amongst the most prevalent complications of diabetes, known for their delayed healing process. Recent research indicates that transcription factor forkhead box M1 (FOXM1) plays a role in promoting diabetic ulcer repair. However, precise mechanisms underlying FOXM1 functions this context remain unclear. This study aimed to clarify tripartite motif‐containing protein 72 (TRIM72)‐mediated endoplasmic reticulum stress promotive effects. Immunohistochemistry revealed...
Abstract Hailey–Hailey disease (HHD) is a rare, autosomal, dominant, and hereditary skin disorder characterized by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 (ATP2C1) encodes the protein secretory pathway Ca2 + ATPase1 (SPCA1), playing critical role in HHD pathogenesis. Therefore, we aimed to investigate effect of ATP2C1 knockdown on keratinocyte cultures that mimicked HHD. levels cytoskeletal tight junction proteins such as SPCA1, P-cofilin,...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the most prevalent form of head cancer, with an escalating incidence rate dismal survival outcomes. Endoplasmic reticulum stress (ERS) occurs when misfolded or unfolded proteins accumulate in endoplasmic (ER), it often observed tumors, including HNSCC. Relevant studies have demonstrated prognostic significance ERS-related long non-coding RNAs (lncRNAs) various cancers. However, relationship between ERS lncRNAs HNSCC has received...