Wenwen Chen

ORCID: 0000-0002-2586-9234
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Ear Surgery and Otitis Media
  • Liver Disease Diagnosis and Treatment
  • Tracheal and airway disorders
  • Nasal Surgery and Airway Studies
  • Chronic Disease Management Strategies
  • Tryptophan and brain disorders
  • Dialysis and Renal Disease Management
  • Cardiac, Anesthesia and Surgical Outcomes
  • Facial Nerve Paralysis Treatment and Research
  • Sinusitis and nasal conditions
  • Hepatitis C virus research
  • Cardiac Health and Mental Health
  • Obesity, Physical Activity, Diet
  • Adipose Tissue and Metabolism
  • Nutritional Studies and Diet
  • Long-Term Effects of COVID-19
  • Diet and metabolism studies
  • PARP inhibition in cancer therapy
  • Retinal Diseases and Treatments
  • Anesthesia and Neurotoxicity Research
  • COVID-19 and Mental Health
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Sleep and related disorders
  • Traditional Chinese Medicine Studies

Sichuan University
2017-2025

Fujian Medical University
2025

State Key Laboratory of Biotherapy
2020-2024

Nanjing University of Chinese Medicine
2022-2024

First Affiliated Hospital of Wenzhou Medical University
2022-2024

West China Medical Center of Sichuan University
2021-2024

Guangzhou Development Zone Hospital
2023-2024

Wenzhou Medical University
2022-2024

Min Sheng General Hospital
2022-2024

University of Electronic Science and Technology of China
2024

Oxidative stress is correlated with sleep quality. A common tool for evaluating dietary and lifestyle exposures to oxidative the Balance Score (OBS), higher OBS suggesting more substantial antioxidant exposures. The relationship between quality unclear. Investigating association was purpose of this study. To figure out quality, we utilized weighted linear models logistic regression. Adjusted were also examined. 6300 participants who took part in National Health Nutrition Examination Survey...

10.1016/j.jad.2023.07.040 article EN cc-by-nc Journal of Affective Disorders 2023-07-11

The association between patterns of physical/mental activity and dementia how it is affected by disease susceptibility remains unknown. We aimed to examine the physical mental whether can be modified dementia.In a prospective cohort study based on UK Biobank, 501,376 dementia-free participants were recruited in 2006-2010 followed from 1 year after recruitment date until end 2019 for ascertainment dementia. Data (i.e., at leisure time, housework-related activity, transportation) intelligence,...

10.1212/wnl.0000000000200701 article EN cc-by-nc-nd Neurology 2022-07-28

The association between hyperuricemia/gout with cardiovascular diseases (CVD) have been investigated. However, whether the magnitude of associations differs hyperuricemia and gout, causality these associations, remains inconclusive.Based on UK Biobank, we conducted a cohort analysis including 431,967 participants, who were categorized as hyperuricemia, normal groups at recruitment, followed up for CVD until December 2019. phenotypic was estimated by Cox regression, adjusting multiple...

10.3389/fmed.2021.817150 article EN cc-by Frontiers in Medicine 2022-03-23

Abstract Anxiety/stress-related disorders have been associated with multiple diseases, whereas a comprehensive assessment of the structure and interplay subsequent diseases their genetic underpinnings is lacking. Here, we first identify 136, out 454 tested, medical conditions incident anxiety/stress-related attended in specialized care using population-based cohort from nationwide Swedish Patient Register, comprising 70,026 patients 1:10 birth year- sex-matched unaffected individuals. By...

10.1038/s41467-024-45445-2 article EN cc-by Nature Communications 2024-02-08

Background Oxidative Balance Score (OBS) is a tool for assessing the oxidative stress-related exposures of diet and lifestyle. The study aimed to investigate association between OBS low muscle mass. Methods Overall, 6,307 individuals over age 18 were assessed using data from 2011 2018 National Health Nutrition Examination Survey (NHANES). Weighted logistic regression models used, together with adjusted models. Results There was negative relationship mass [odds ratio (OR): 0.96, 95%...

10.3389/fnut.2024.1358231 article EN cc-by Frontiers in Nutrition 2024-04-05

Adverse life experiences have been associated with increased susceptibilities to psychopathology in later life. However, their impact on psychological responses following physical trauma remains largely unexplored. Based the China Severe Trauma Cohort, we conducted a cohort study of 2937 patients who were admitted Medical Center West Hospital between June 2020 and August 2023. experiences, including childhood maltreatment (5 subtypes, measured by Childhood Questionnaire-Short Form) adverse...

10.1186/s12916-025-03861-1 article EN cc-by-nc-nd BMC Medicine 2025-01-21

The "Life's Essential 8" (LE8) score is an assessment of cardiovascular health recently introduced by the American Heart Association. This study aimed to explore correlation total LE8 and its individual metrics with all-cause disease (CVD) mortality in patients hypertension. Data from 10,556 hypertension adults were retrieved National Health Nutrition Examination Survey (NHANES) 2005 2018. After a median follow-up 6.75 years, high scores (≥ 75 points) showed significantly lower rates all...

10.1038/s41598-025-89773-9 article EN cc-by-nc-nd Scientific Reports 2025-02-17

Background. Preptin is a novel hormone that co-secreted with insulin and amylin from the pancreatic β-cells. increases glucose-mediated secretion, while binding of endogenous preptin by antipreptin antibodies decreases secretion. Thus, it appears to act as physiological amplifier

10.1080/07853890802244142 article EN Annals of Medicine 2008-07-11

As an attractive alternative to traditional diagnostic techniques, wireless capsule endoscopy (WCE) can be considered a disruptive technology.This paper presents wirelessly powered micro-robot based on the Archimedes spiral with high integration of active locomotion module.A WCE prototype was fabricated and tested. Including video camera end cap, outer dimensions were diameter (Φ) 16 mm, length 45 mm. Experiments demonstrated that anchoring force overcome 2.6 N wrap each leg. The improved...

10.1002/rcs.1520 article EN International Journal of Medical Robotics and Computer Assisted Surgery 2013-07-11

An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies.In this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 a clinical diagnosis diseases inpatient hospital before outbreak (defined as January 31st, 2020), while remaining constituted reference group. We then followed both groups...

10.1186/s12883-021-02536-7 article EN cc-by BMC Neurology 2022-01-07

Habitual coffee consumption has been associated with multiple health benefits. A comprehensive analysis of disease trajectory and comorbidity networks in relation to is, however, currently lacking. We aimed comprehensively examine the outcomes habitual consumption, through clarifying its networks. Based on UK Biobank cohort, we included 395,539 individuals available information intake collected at recruitment between 2006 2010. These were categorized as having low (<1 cup per day), moderate...

10.1093/ajcn/nqac148 article EN cc-by-nc American Journal of Clinical Nutrition 2022-07-18

Abstract Aims Genetic and lifestyle factors are both major contributors to valvular heart disease (VHD). However, it is still uncertain whether genetic susceptibility alters the association between VHD. We aimed investigate VHD in different risk backgrounds. Methods results A prospective cohort study was carried out on 499 341 participants without at baseline. The assessment of included smoking, alcohol consumption, diet, activity, sleep. separately measured by polygenic scores (PRSs) family...

10.1093/eurjpc/zwad177 article EN European Journal of Preventive Cardiology 2023-06-01

Objectives/Hypothesis One of the primary goals endoscopic sinus surgery (ESS) is to create widely patent paranasal ostia, but lateralization middle turbinate (MT) after ESS can obstruct otherwise ethmoid and maxillary sinuses. The aim this study was evaluate effectiveness turbinate‐septal suturing in preventing MT. Study Design A prospective, randomized, blinded controlled study. Methods performed 120 patients who had undergone ESS. were randomized receive nasal (group A) or suture plus...

10.1002/lary.24820 article EN The Laryngoscope 2014-07-07

Whether a genetic predisposition to psychiatric disorders is associated with coronavirus disease 2019 (COVID-19) unknown.Our analytic sample consisted of 287,123 white British participants in UK Biobank who were alive on 31 January 2020. We performed genome-wide association study (GWAS) analysis for each disorder (substance misuse, depression, anxiety, psychotic disorder, and stress-related disorders) randomly selected half the population ("base dataset"). For other ("target dataset"),...

10.1186/s12916-022-02520-z article EN cc-by BMC Medicine 2022-08-23

Perioperative neurocognitive disorder, particularly postoperative cognitive impairment, is common and associated with multiple medical social adversities, although data from China are lacking.To examine the incidence, trajectory, risk factors for subjective short-term memory impairment after surgery in Chinese population.This cohort study used Surgery Anesthesia Cohort to assess surgical patients aged 40 65 years 2 centers between July 15, 2020, March 31, 2023, active follow-up within 1 year...

10.1001/jamanetworkopen.2023.36985 article EN cc-by-nc-nd JAMA Network Open 2023-10-10
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