A5101554550- Gut microbiota and health
- NF-κB Signaling Pathways
- Probiotics and Fermented Foods
- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Microbial Metabolites in Food Biotechnology
- Diet, Metabolism, and Disease
- Signaling Pathways in Disease
- Autoimmune Bullous Skin Diseases
- Plant Reproductive Biology
- Wound Healing and Treatments
- Psoriasis: Treatment and Pathogenesis
- Medical Research and Treatments
- Immune Response and Inflammation
- Immune cells in cancer
- FOXO transcription factor regulation
- Biofuel production and bioconversion
- Immunodeficiency and Autoimmune Disorders
- Peroxisome Proliferator-Activated Receptors
- Educational Reforms and Innovations
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salmonella and Campylobacter epidemiology
- Photosynthetic Processes and Mechanisms
- Carcinogens and Genotoxicity Assessment
- Sexual Differentiation and Disorders
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Nanchang University
2021-2024
Hefei Institutes of Physical Science
2024
Chinese Academy of Sciences
2024
Zhejiang Normal University
2024
State Key Laboratory of Food Science and Technology
2021-2024
The First People’s Hospital of Lianyungang
2019-2024
Xian Yang Central Hospital
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xi'an Medical University
2020
Exopolysaccharides (EPSs) have been shown to possess wide-ranging of physiological functions, including antioxidant, anticancer, and immunomodulatory. However, there is a scarcity research focused on the probiotic function EPSs isolated from Bifidobacteria, further investigation needed reveal mechanisms underlying their functions. In this study, were purified Bifidobacterium animalis subsp. Lactis SF (SF-EPS), potential SF-EPS analyzed by in vitro antioxidant capacity assays human fecal...
Non-alcoholic fatty liver disease (NAFLD) is a common chronic hepatic condition whose impact on human health increasingly significant. The imbalance of the gut microbiome, linked to insulin resistance, heightened intestinal permeability, and pro-inflammatory reactions, may be linchpin in development NAFLD. In our research, Lactiplantibacillus plantarum ZDY2013 administration for 12 weeks microbiota dysbiosis induced by high-fat, high-fructose, high-cholesterol (FHHC) diet male C57BL/6n mice...
Abstract Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that acts through its receptor fibroblast growth factor-inducible 14 (Fn14). Recent studies demonstrated the TWEAK/Fn14 signals participate in development psoriasis. The purpose this study was to further explore effect Fn14 inhibition on experimental Psoriasis-like skin disease induced wild-type and Fn14-knockout BALB/c mice. We found deficiency ameliorates psoriasis-like lesion model,...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic with many influencing factors. With the increasing role of gut-liver axis in various diseases, research on prevention and treatment NAFLD probiotics increasing. In present study, Bifidobacterium animalis subsp. strain, B. lactis SF, was isolated from feces healthy infants characterized by sequencing 16S rDNA. A systematic probiotic evaluation carried out, diet-induced mouse model constructed to study effect mechanism SF NAFLD....
Abstract Background Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays pivotal role in the pathogenesis LN. Currently, there are various therapies for patients with LN; however, most them associated considerable side effects. We confirmed previously that ALW (ALWPPNLHAWVP), 12-amino acid peptide, inhibited binding polyclonal anti-dsDNA antibodies to mesangial cells isolated glomeruli vitro. In...
Acute liver injury (ALI) has a high mortality rate of approximately 20-40%, and it is imperative to find complementary alternative drugs for treating ALI. A carbon tetrachloride (CCl4)-induced ALI mouse model was established explore whether dietary intervention can alleviate in mice. Intestinal flora, intestinal integrity, biomarkers hepatic function, systemic inflammation, autophagy, apoptosis signals were detected through real-time PCR, hematoxylin-eosin staining, 16S rRNA gene sequencing,...
The interaction of tumor necrosis factor-like weak inducer apoptosis (TWEAK) and its receptor fibroblast growth factor inducible 14 (Fn14) participates in inflammatory responses, fibrosis, tissue remodeling, which are central the repair processes wounds. Fn14 is expressed main skin cells including dermal fibroblasts. This study was designed to explore therapeutic effect TWEAK on experimental burn wounds relevant mechanism underlying such function. Third-degree burns were introduced two...
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) acts through its receptor fibroblast growth inducible 14 (Fn14), and participates in skin inflammation. Both TWEAK Fn14 are highly expressed lesions patients with atopic dermatitis. The purpose this study was to further explore the effect inhibition on experimental Experimental dermatitis induced wild-type knock-out BALB/c mice. TWEAK/Fn14 interaction keratinocytes studied an in-vitro model deficiency ameliorates mice model,...
Diabetes mellitus (DM) is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β-cell dysfunction. In previous study, endoplasmic reticulum (ER) stress could increase C/EBP homologous protein (CHOP) expression through inhibiting C/EBβ transcriptional activity. However, role CHOP peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in dysfunction remains unknown. The aim study was to investigate effect PGC-1α potential...
A high-salt diet (HSD) is one of the key risk factors for hypertension and kidney injury. In this study, a HSD C57BL/6J mice model was established with 4% NaCl, then different concentrations Lactobacillus plantarum ZDY2013 were intragastrically administered 2 weeks to alleviate HSD-induced renal For 16S rRNA gene sequencing, non-targeted metabonomics, real-time fluorescent quantitative PCR, Masson's staining used investigate mechanism L. in alleviating damage. Results showed that caused...
Salmonella Typhimurium is widely distributed in food. It can colonise the gastrointestinal tract after ingestion, causing lamina propria edema, inflammatory cell infiltration, and mucosal epithelial decomposition. A high-fat diet (HFD) induce an response, but whether HFD increase infection level of S. unknown. We established a model enterica subsp. serovar strain ATCC 13311 healthy adult mice with maintenance (MD) or to explore effect Lactiplantibacillus plantarum 1201 intervention on...
Abstract Background Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in various cellular effects by engaging its receptor Fn14. Increased levels soluble TWEAK are associated with systemic autoimmunity patients lupus erythematosus, rheumatoid arthritis or dermatomyositis. However, the role bullous pemphigoid (BP) remains unknown. Objectives To explore potential TWEAK/Fn14 activation pathogenesis BP. Methods Twenty-three BP and twenty healthy donors were recruited. The...
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The GLR2 transcription factor regulates glufosinate resistance and enhances abiotic stress tolerance in rice through interaction with the GLR1 modulation of gene expression.
Introduction A few past experimental studies have indicated that exposure to volatile organic compounds (VOCs) might be a potential risk factor for diabetes retinopathy (DR). However, these findings lack substantial support from extensive epidemiological research. This large-scale cross-sectional study aimed examine whether low levels of VOCs in the general population is associated with mellitus (DM) and DR. Methods The analytical data was National Health Nutrition Examination Survey...
Grain size and shape are critical agronomic traits that directly impact rice grain yield. Identifying genes control these can provide new strategies for yield improvement. In this study, we characterized a mutant, reduced length (rgl), which exhibited decreased due to cell proliferation. Map-based cloning identified base deletion in OsRGL2, gene encoding keratin-associated protein (KAP), as the cause of mutant phenotype. CRISPR-Cas9-generated OsRGL2 knockout mutants also displayed length,...
To observe the electrocardiogram (ECG) changes of programmed death receptor 1 (PD-1)/programmed receptor-ligand (PD-L1) immune checkpoint inhibitors before and after immunotherapy patients during clinical antitumor process, to explore occurrence influencing factors cardiotoxicity inhibitors.