A5101622316- Salivary Gland Disorders and Functions
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Diet, Metabolism, and Disease
- Respiratory and Cough-Related Research
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microbial Metabolites in Food Biotechnology
- Oral Health Pathology and Treatment
- Polysaccharides and Plant Cell Walls
- Diabetes and associated disorders
- Lipid metabolism and disorders
- T-cell and B-cell Immunology
Peking University
2021-2024
Peking University People's Hospital
2021-2024
Ningbo University
2014
Scope This study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjögren's syndrome (pSS). Methods results Non‐obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg −1 d ), high (10 low interleukin (IL)‐2 (25 000 IU/d), control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces salivary gland inflammation compared with group (histological score p vs Control...
Parkinson's disease (PD) is a neurodegenerative movement d'isorder that affects ~2% of the population aged ≥65 years. NAD(P)H‑quinone oxidoreductase 1 (NQO1) and tumor necrosis factor‑α (TNF‑α) are two important factors in generation oxidative stress PD. The aim present study was to assess association NQO1 factor (TNF) polymorphisms with A meta‑analysis performed included data from 15 studies comprising 2,858 patients 2,907 healthy controls. results showed TNF‑1031 (rs1799964) significantly...
Abstract Objectives Influenza vaccination is effective in preventing infections most people. This study aimed to assess the changes of immune responses primary Sjögren’s Syndrome (pSS) patients after influenza and determine safety vaccination. Methods A total 17 with pSS 16 healthy controls (HCs) were included. Peripheral mononuclear cells analysed by flow cytometry. Vaccine-specific antibodies determined ELISA. Clinical features serological monitored. Results The percentages T follicular...
Abstract Objective To identify predictors for lupus low disease activity state (LLDAS), early-achieved LLDAS and long-term activity, to refine a prognostic stratification tool use in active SLE patients. Method A total of 245 patients were enrolled, followed up quarterly from 2014 2016. LLDAS-50 was defined as the maintenance ≥50% observed time. at 3 months after cohort entry (LLDAS-3mo) considered an LLDAS. Multivariate analysis performed LLDAS, activity. Based on factors associated with...
Given increased acceptance of the CoronaVac, there is an unmet need to assess safety and immunogenic changes CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral cellular responses patient RD after a three-dose immunization regimen CoronaVac. stable condition and/or low disease activity (n = 40) or healthy controls were assigned 1:1 ratio receive (Sinovac). The prevalence anti-receptor binding domain (RBD) antibodies neutralizing was similar between...