A5103103768- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Curcumin's Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Cardiac Fibrosis and Remodeling
- Advanced MRI Techniques and Applications
- Appendicitis Diagnosis and Management
- Hormonal Regulation and Hypertension
- Axon Guidance and Neuronal Signaling
Peking University
2025
Peking University Sixth Hospital
2025
Central Hospital of Zibo
2014-2025
Third Affiliated Hospital of Southern Medical University
2025
Nanfang Hospital
2011-2024
Southern Medical University
2011-2024
Heilongjiang Provincial Hospital
2016-2023
Xinxiang Medical University
2014-2022
First Affiliated Hospital of Xinxiang Medical University
2012-2022
New York Psychoanalytic Society and Institute
2016
Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was assess whether BDNF promoter methylation peripheral blood able predict the risk AD. A total 44 AD patients and 62 age- gender-matched controls were recruited current case-control study. Using bisulphite pyrosequencing technology, we evaluated four CpG sites BDNF. Our results showed that significantly higher cases...
Skin wound healing is a critical and complex biological process after trauma. This activated by signaling pathways of both epithelial nonepithelial cells, which release myriad different cytokines growth factors. Hepatocyte factor (HGF) cytokine known to play multiple roles during the various stages healing. study evaluated benefits HGF on reepithelialization investigated its mechanisms action. Gross histological results showed that significantly accelerated in diabetic (DB) rats. increased...
Curcumin, an agent traditionally utilized for its preventative action against tumorigenesis, oxidation, inflammation, apoptosis and hyperlipemia, has also been used in the treatment of Alzheimer's disease (AD). Recent advances study AD have revealed astrocytes (AS) as being key factors early pathophysiological changes AD. Glial fibrillary acidic protein (GFAP), a marker specific to AS, is markedly more manifest during morphological modifications neural degeneration signature onset Several...
Caffeic acid is a type of phenolic and organic acid. It found in food (such as tomatoes, carrots, strawberries, blueberries wheat), beverages wine, tea, coffee apple juice) well Chinese herbal medicines. In the present study, we examined effects caffeic on learning deficits rat model Alzheimer's disease (AD). The rats were randomly divided into three groups: i) control group, ii) AD group iii) group. significantly rescued increased cognitive function with demonstrated by Morris water maze...
We tested the relationship between genotype, gene expression and suicidal behavior major depressive disorder (MDD) in live subjects postmortem samples for three genes, associated with hypothalamic-pituitary-adrenal axis, behavior, MDD; FK506-binding protein 5 (FKBP5), Spindle kinetochore-associated 2 (SKA2), Glucocorticoid Receptor (NR3C1).Single-nucleotide polymorphisms (SNPs) haplotypes were association MDD a (N = 277) sample 209). RNA-seq was used to examine isoform-level brain (Brodmann...
There is growing evidence of the position microRNAs (miRs) in Alzheimer's disease (AD), thus our objective was to discuss impact miR-129-5p regulating nerve injury and inflammatory response AD rats by modulating SOX6 expression. The rat model established injecting Aβ25-35 into brain. pathological changes, ultrastructure, number neurons, cell degeneration apoptosis hippocampal tissue were observed vivo. MiR-129-5p, SOX6, IL-1β, TNF-α, Bcl-2 Bax expression serum tissues detected ELISA, RT-qPCR...
Curcumin is a natural polyphenol with powerful antioxidant and anti-inflammatory properties. The present study evaluated the protective effect of curcumin on myocardial injury in rats as well mechanisms underlying these effects, examined expression nuclear factor-κB (NF-κB), peroxisome proliferator-activated receptor-γ (PPAR-γ) B-cell leukemia/lymphoma-2 (Bcl-2) following infarction. A rat model infarction was successfully established. Hematoxylin eosin staining showed cellular atrophy...
The inflammatory response has adverse effects on left ventricular (LV) function and remodeling post-myocardial infarction (MI). Interleukin (IL)-33 is considered to have anti-inflammatory properties. present study examined whether the suppression of inflammation with IL-33 was able attenuate LV dysfunction post-MI. MI model induced mice were treated either saline or recombinant IL-33. Inflammatory mediators, functional changes structural evaluated. significantly suppressed macrophage...
Alzheimer's disease (AD) is a common neurodegenerative disorder that can destroy the memory of sufferers and lead to distress for individual society. Brain-derived neurotrophic factor (BDNF) butyrylcholinesterase (BCHE) are two genes associated with β-amyloid plaques neurofibrillary tangles key factors in pathophysiology AD. The aim current meta-analysis was evaluate association between BDNF Val66Met (rs6265), C270T (rs2030324) BCHE-K (rs1803274) polymorphisms A comprehensive performed using...
Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear.Inhibitory factors axonal regeneration have shown to cause a series pathophysiological changes in early period AD.In this study, co-receptor (Nogo receptor; NgR) three growth-inhibitory proteins was examined, effects curcumin on spatial learning memory abilities hippocampal growth were investigated amyloid β-protein (Aβ)1-40-induced AD rats.Results showed that...
Schizophrenia (SCZ) is a severe complex psychiatric disorder that generates problems for the associated family and society causes disability with regards to work patients. The aim of present study was assess contribution 10 genetic polymorphisms SCZ susceptibility. Meta‑analyses were conducted using data without limitation time or language. A total 27 studies 7 genes selected meta‑analyses. Two found be significantly SCZ. SNAP25 rs3746544 shown increase risk by 18% [P=0.01; odds ratio (OR),...
Cardiomyocyte hypertrophy is a threat to human health due the probability of sudden heart failure‑induced mortality. Previous studies have demonstrated that nuclear factor activated T cells cytoplasmic 3 (NFATC3) important in process cardiomyocyte hypertrophy. However, molecular mechanism underlying alteration expression levels NFATC3 during has remained be fully elucidated. In order shed light on mechanism, present study employed several approaches, including measurement cell surface area,...