A5008586520- Acute Myeloid Leukemia Research
- Probiotics and Fermented Foods
- Gut microbiota and health
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infant Nutrition and Health
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Microbial Metabolites in Food Biotechnology
- Retinoids in leukemia and cellular processes
- Cholinesterase and Neurodegenerative Diseases
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Nerve injury and regeneration
- Hematological disorders and diagnostics
- Microbial Metabolism and Applications
- Escherichia coli research studies
- Advanced Biosensing Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Protein purification and stability
- Pancreatic and Hepatic Oncology Research
- Protein Degradation and Inhibitors
- Vascular Tumors and Angiosarcomas
Taizhou Central Hospital
2019-2023
Taizhou University
2021-2023
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2023
Inserm
2023
Université Côte d'Azur
2023
Centre National de la Recherche Scientifique
2023
Zhejiang University
2017-2022
First Affiliated Hospital Zhejiang University
2018-2022
De Lin Institute of Technology
2016-2022
Sun Yat-sen University
2019
This study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics in vitro . The deconjugation potential bile acid was determined using high-performance liquid chromatography. HepG2 cells were cultured with strains high BSH activity. triglyceride (TG) apolipoprotein B (apo B) secretion by evaluated. Our results show that bile-acid abilities Pediococcus acidilactici NBHK002, Bifidobacterium adolescentis NBHK006,...
Alzheimer's disease (AD) is a common neurodegenerative disorder that can destroy the memory of sufferers and lead to distress for individual society. Brain-derived neurotrophic factor (BDNF) butyrylcholinesterase (BCHE) are two genes associated with β-amyloid plaques neurofibrillary tangles key factors in pathophysiology AD. The aim current meta-analysis was evaluate association between BDNF Val66Met (rs6265), C270T (rs2030324) BCHE-K (rs1803274) polymorphisms A comprehensive performed using...
Although cytarabine has been widely considered as one of the chemotherapy drugs for high-risk myelodysplastic syndromes (MDS), overall response rate is only approximately 20-30%. Nuclear factor erythroid 2-related 2 (NRF2, also called NFE2L2) shown to play a pivotal role in preventing cancer cells from being affected by chemotherapy. However, it not yet known whether NRF2 can be used prognostic biomarker MDS, or elevated levels are associated with resistance. Here, we found that expression...
SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hematopoietic diseases when mutated. By generating novel exon 6 conditional knockout mouse model, we describe an essential role of Setd2 in maintaining the adult stem cells. Loss results leukopenia, anemia, and increased platelets accompanied by hypocellularity, erythroid dysplasia, mild fibrosis bone marrow. mice show significantly decreased progenitor cells except for progenitors. fail to...
Decitabine (DAC) is used as the first-line therapy in patients with higher-risk myelodysplastic syndromes (HR-MDS) and elderly acute myeloid leukaemia (AML) unsuitable for intensive chemotherapy. However, clinical outcomes of treated DAC a monotherapy are far from satisfactory. Adding all-trans retinoic acid (ATRA) to reportedly benefitted MDS AML patients. underlying mechanisms remain unclear need further explorations laboratory experiments.We cell lines primary cells evaluate combined...
Through a high-fat diet, obesity leads to cardiomyocyte dysfunction and apoptosis. In addition, there is no evidence that probiotics have potential health effects associated with cardiac apoptosis in obese rats. The present study aimed explore the of on rats fed diet (HF). Eight‑week‑old male Wistar were separated randomly into five equally sized experimental groups: Normal (NC) (HFC) groups, supplemented low (HFL), medium (HFM) or high (HFH) doses multi‑strain groups. subsequently studied...
The Wnt and Hedgehog signalling pathways serve key roles in diverse developmental processes. However, the molecular associations between these two remains unclear. Previous transcriptome studies on human foreskin fibroblasts have indicated that activation induces expression of genes, including smoothened, frizzled class receptor (Smo) GLI family zinc finger 1 (Gli1). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) results revealed Wnt3a treatment induced Smo, patched...
Parkinson's disease (PD) is a neurodegenerative movement d'isorder that affects ~2% of the population aged ≥65 years. NAD(P)H‑quinone oxidoreductase 1 (NQO1) and tumor necrosis factor‑α (TNF‑α) are two important factors in generation oxidative stress PD. The aim present study was to assess association NQO1 factor (TNF) polymorphisms with A meta‑analysis performed included data from 15 studies comprising 2,858 patients 2,907 healthy controls. results showed TNF‑1031 (rs1799964) significantly...
Abstract Telomeric repeat binding factor 2 (TRF2) binds to telomeres and protects chromosome ends against the DNA damage response senescence. Although expression of TRF2 is downregulated upon cellular senescence in various aging tissues, including skeletal muscle very little known about contribution this decline aging. We previously showed that loss myofibers does not trigger telomere deprotection but mitochondrial dysfunction leading an increased level reactive oxygen species. show here...
Background: Tumor-associated calcium signal transducer 2 (TROP2) is over expressed in various kinds of human cancers and plays important roles the proliferation, invasion metastasis tumor cells.However, expression molecular mechanism TROP2 thyroid papillary carcinoma (PTC) are unclear.Methods: The expressions PTC control tissue were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) immunohistochemistry.The proliferation cell lines examined cloning transwell...
Abstract Purpose To explore the relevance of cytogenetic or molecular genetic abnormalities to clinical variables, including and laboratory characteristics prognosis in Chinese patients with myelodysplastic syndromes (MDS). Methods A total 634 consecutive diagnosed MDS at The First Affiliated Hospital, Zhejiang University School Medicine from June 2008 May 2018 were retrospectively included this study. All had evaluable analysis, 425 MDS‐related mutations sequencing. Results 38.6% displayed...
Abstract Chronic myelomonocytic leukemia (CMML) is a rare disease of elderly people characterized by the presence sustained peripheral blood monocytosis, overlapping features myeloproliferation, and myelodysplasia. We present large retrospective study 156 CMML patients in China. Mean age at diagnosis was 68 years old (range 23‐91). According to CMML‐specific prognostic scoring system (CPSS), 10 (8.3%) were low risk, 27 (22.5%) intermediate‐1 72 (60%) intermediate‐2 11 (9.2%) high risk. A...