A5003289715- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Pleural and Pulmonary Diseases
- Cancer-related gene regulation
- Alcohol Consumption and Health Effects
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Gastric Cancer Management and Outcomes
- Coronary Interventions and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Sirtuins and Resveratrol in Medicine
- Quinazolinone synthesis and applications
- Hemispheric Asymmetry in Neuroscience
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Wnt/β-catenin signaling in development and cancer
- Smart Cities and Technologies
Sichuan University
2011-2025
West China Hospital of Sichuan University
2016-2025
Beijing Normal University
2025
Tongji University
2018-2024
Shanghai Pulmonary Hospital
2018-2024
Qilu Hospital of Shandong University
2024
Xi'an University of Science and Technology
2024
Tsinghua University
2024
Guangdong Province Women and Children Hospital
2021-2023
Peking Union Medical College Hospital
2023
Urban–rural fragmentation represents a significant challenge encountered by nations globally, particularly in both developing and developed contexts, during the modernisation process. This study examines effects of rural land system reform on facilitating integrated development between urban areas. The analysis impact 2010 liberalisation transfer policy employs dual machine learning model, utilising provincial-level data from China spanning 2005 to 2022, address limitations traditional...
Background Dual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be life-threatening complication of therapy. It is considered to result from severe systemic inflammatory response mediated by increased expression cytokines, chemokines, adhesion molecules on differentiating blast cells. The kidney, as vital organ rich in the capillary endothelium, could targeted...
The digital economy plays an increasingly crucial role in bridging the gap between urban and rural areas. This study investigates how development of can foster integrated areas by optimizing factor allocation, with emphasis on its potential to narrow urban-rural divide. aims examine impact integration, focusing particularly mediating optimized allocation. Using panel data from 30 Chinese provinces 2011 2022, we construct indicators for integration. analysis employs a two-way fixed-effects...
Src family tyrosine kinase (SFK) activation is associated with ovarian cancer progression. Therefore, SFKs are targets for the development of potential treatments cancer. Dasatinib a inhibitor that SFK activity, and used treatment B cell Abelson lymphomas. At present time, effect dasatinib on not clear. The aim study was to investigate antitumor activity dasatinib, alone in combination paclitaxel, vitro vivo. In study, expression phospho‑Src-Y416 (p‑Src) measured six lines using western...
Abstract N6-methyladenosine (m 6 A) is the most prevalent modification of eukaryotic RNA, which recognized by m A-binding proteins (“readers”) and thereby mediates multiple biological processes. Dysregulation A readers has been linked to various pathologies, but therapeutic potential small molecule inhibitors targeting m6A unknown. Here we report identification characterization a highly potent selective first-in-class inhibitor (YL-5092) YT521-B homology (YTH) domain-containing protein 1...
Sea buckthorn (SB) has been indicated to have hypoglycemic potential, but its effects on glucose in people with impaired regulation (IGR) are still unclear. This work presents a randomized, double-blinded, two-way crossover study. A total of 38 subjects IGR completed the intervention consuming sea fruit puree (SBFP, 90 mL/day, five weeks), washing out (four and then placebo (90 weeks) or reverse order. In our methodology, unified questionnaire was used gather information physical activity...
The clinical efficacy of robot-assisted thoracic surgeries has been explored by numerous recent studies. Nonetheless, since current standard robotic systems (da Vinci Xi system) were intended for multiportal surgical processes and staplers still unavailable in the developing world, obstacles remain concerning feasibility uniportal surgeries.A hybrid robotic-assisted thoracoscopic surgery (RATS) modality utilizing video-assisted (VATS) was investigated Shanghai Pulmonary Hospital....
Abstract Introduction Immune factors contribute to the onset of myelodysplastic syndrome (MDS). Arginine metabolism affects tumor‐associated macrophage (TAM) polarization. This study investigated infiltration TAMs and effect arginine key enzymes on MDS prognosis. Methods We used GEO (Gene Express Omnibus database) dataset “GSE19429” analyze compare metabolism‐associated pathways between patients with excess blasts those without. The markers enzymes, including CD68, iNOS, ARG1 ASS1 were...
Background: Subxiphoid uniportal video-assisted thoracoscopic surgery (SVATS) has been known as feasible and safe approach for lobectomy with acceptable results. Its learning curve is slightly harder than the intercostal approach. The aim of this article to view evolution surgical technique change in results progress a trial guide surgeons aiming apply technique. Methods: Four hundred thirty-eight patients underwent SVATS from September 2014 November 2017. were divided into four groups...
Daratumumab is a humanized anti-CD38 IgG1 monoclonal antibody which could be used for multiple myeloma (MM). MM with plasma-cell leukemia (PCL) transformation highly aggressive and resistant to conventional therapy. Novel therapeutics are needed PCL, daratumumab may play role. We report case of relapsed/refractory (RRMM)-transformed PCL successfully treated daratumumab. The was 42-year-old man who diagnosed 2 years ago relapsed after six cycles bortezomib-based chemotherapy. patient rapidly...
Zanubrutinib is a Bruton tyrosine kinase (BTK) inhibitor used in B cell malignancy treatment and generally well tolerated most patients. Zanubrutinib-induced aseptic meningitis currently not reported. Herein, we present the first case of zanubrutinib-induced meningitis. A 33-year-old woman was diagnosed with relapsed/refractory follicular lymphoma subsequently developed after receiving zanubrutinib treatment. We reviewed literature uncovered lack current reports on or other BTK...
Abstract Benign lesions named pancreatic intraepithelial neoplasia (PanIN) are frequent in the healthy population but precursors to deadly ductal adenocarcinoma (PDAC). Conversion of PanINs PDAC is poorly understood. Here we harness high resolution spatial transcriptomics identify a core transcriptional program associated with invasive growth across human and required for PanIN-to-PDAC progression mice. The malignancy lineage restricted, predominantly comprised transcripts activated drive...
Pneumonectomy is one of the important surgical methods for non-small cell lung cancer (NSCLC). This study evaluated effects laterality on short- and long-term survival NSCLC patients undergoing pneumonectomy.
Background: All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have revolutionized the treatment of acute promyelocytic leukemia (APL). However, management high-risk APL has not been conclusively established. The optimal dosage anthracycline in induction long debated when ATO is added. Objectives: To explore regarding predicators prognosis. Design: This was a retrospective study real-world setting. Methods: High-risk patients defined as white blood cell (WBC) greater than 10 × 9 /L...
One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson's disease (PD) patients less known. This study was aimed to investigate prevalence and risk factors in PD at 1 month 12 months after symptom onset. attending clinic from December 2022 January 2023 were enrolled consecutively study. All participants assessed demographics, details COVID-19 infection, clinical characteristics as well status with Fatigue Severity Scale (FSS) (cutoff ≥...