A5101926017- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Phosphorus and nutrient management
- Cancer-related molecular mechanisms research
- Wastewater Treatment and Nitrogen Removal
- Glaucoma and retinal disorders
- Diabetes Treatment and Management
- Coronary Artery Anomalies
- Climate Change and Health Impacts
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Air Quality and Health Impacts
- Circular RNAs in diseases
- Pituitary Gland Disorders and Treatments
- Retinal Diseases and Treatments
- Platelet Disorders and Treatments
- Diverse Approaches in Healthcare and Education Studies
- Retinopathy of Prematurity Studies
- Pluripotent Stem Cells Research
- Gastric Cancer Management and Outcomes
- CRISPR and Genetic Engineering
- Congenital Heart Disease Studies
- Nausea and vomiting management
- Cancer Mechanisms and Therapy
Shanghai Jiao Tong University
2023-2025
Renji Hospital
2025
Sichuan University
2004-2025
State Key Laboratory of Oral Diseases
2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Xiangya Hospital Central South University
2018-2024
Central South University
2011-2024
Stem cells exist in vitro a spectrum of interconvertible pluripotent states. Analyzing hundreds hiPSCs derived from different individuals, we show the proportions these states vary considerably across lines. We discover 13 gene network modules (GNMs) and regulatory (RNMs), which are highly correlated with each other suggesting that coordinated co-accessibility elements RNMs likely underlie expression genes GNMs. Epigenetic analyses reveal networks underlying self-renewal pluripotency more...
Abstract The causal variants and genes underlying thousands of cardiac GWAS signals have yet to be identified. Here, we leverage spatiotemporal information on 966 RNA-seq samples perform an expression quantitative trait locus (eQTL) analysis detecting eQTLs considering both eGenes eIsoforms. We identify 2,578 associated with a specific developmental stage-, tissue- and/or cell type. Colocalization between eQTL five traits identified high posterior probabilities for being in 210 loci. Pulse...
Background: This study explores the feasibility and effectiveness of ultrasound-guided acupoint injection at Neiguan to prevent postoperative nausea vomiting (PONV) after laparoscopic cholecystectomy. Methods: A total 60 patients undergoing cholecystectomy in General Surgery Department Zhejiang Hospital from February 2021 August were enrolled this study. The randomly divided into group (n = 30) control 30). received injections tropisetron bilateral acupoints, while those intravenous...
Ultrasound scanning anomalies in fetuses are a cause for concern and often necessitate further diagnostic procedures. This retrospective study evaluated the utility of trio whole exome sequencing (trio-WES) diagnosis with ultrasound anomalies. We included diagnosed fetal referred to First Affiliated Hospital Chongqing Medical University between November 2018 July 2023. Fetal were classified into structural anomalies, dynamic soft markers. Karyotype analysis, chromosomal microarray analysis...
Background: Computed tomography (CT) is used worldwide; however, recent studies suggest that CT radiation exposure during childhood may be a risk factor for cancer, although the data are inconsistent. Methods: A comprehensive search of electronic databases including PubMed, SpringerLink, Embase, Cochrane Library, Elsevier/ScienceDirect, Medline, Orbis, and Web Science from January 1990 to November 2018 observational epidemiologic reporting associations between in subsequent cancer was...
Purpose To evaluate the effectiveness of Spot photoscreener and SW800 vision screener in detecting amblyopia risk factors Chinese children between 4 6 years age. Methods One hundred thirteen (226 eyes) underwent complete ophthalmologic examination, cycloplegic retinoscopy refraction, prism cover tests photoscreen using both (v2.1.4) (v1.0.1.0) photoscreeners. The agreement results obtained from was evaluated by paired t-test as well Pearson correlation test. sensitivity specificity were...
Abstract Despite conventional glucocorticoid and antifungal therapy, acute exacerbation hospitalization occur frequently in patients with allergic bronchopulmonary aspergillosis (ABPA). Whether omalizumab is an effective safe treatment for adult ABPA complicating asthma. Patients asthma who were treated from October 2019 to May 2023 collected five tertiary hospitals evaluated. The frequencies of hospitalization; the number eosinophils; total IgE levels; average monthly medical dosages after...
As an epigenetic player, long noncoding RNAs (LncRNAs) have been reported to participate in multiple biological processes; however, their functions silica-induced pulmonary fibrosis (SIPF) occurrence and development remain incompletely understood.Five case/control pairs were used perform integrated transcriptomes analysis of lncRNA mRNA. Prediction mRNA was aided by the Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases. Additionally, we constructed a coexpression network...
Clinical relevance Large‐scale data on the association between body stature with biometry parameters and refraction in young adults facilitates an understanding of myopia development. Taller persons have eyes more negative refractions, longer axial lengths, deeper anterior chambers, flatter corneas, higher length‐corneal radius ratio.Background To determine relationship ocular adults.Methods This was a cross‐sectional university‐based study 16‐ to 26‐year‐old students China. Cycloplegic...
To investigate the distribution of ocular biometric parameters and its association to refraction in university students central China.Ocular including axial length (AL), corneal thickness (CCT), keratometry power (K), anterior chamber depth (AQD) lens (LT) were measured by an optical biometry a cohort students. Corneal radius curvature (CR), position (LP), (PBennett ), vitreous (VCD) AL ratio (AL/CR) calculated. Cycloplegic was using autorefractor.A total 7650 undergraduate participated this...
Background Dual antiplatelet therapy based on aspirin and P2Y12 receptor antagonists such as clopidogrel is currently the primary treatment for coronary artery disease (CAD). However, a percentage of patients exhibit resistance, in which genetic factors play vital roles. This study aimed to investigate roles GAS5 (growth arrest-specific 5) its rs55829688 polymorphism response with CAD. Methods Results A total 444 CAD receiving dual from 2017 2018 were enrolled evaluate effect single...
Dual antiplatelet treatment with aspirin and clopidogrel is the standard therapy for patients undergoing percutaneous coronary intervention (PCI). However, a portion of suffer from resistance (CR) consequently recurrence cardiovascular events. Genetic factors such as loss-of-function variants CYP2C19 contribute lot to CR. Recently, N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) rs2254638 polymorphism reported be associated response. To validate association between N6AMT1 response, 435...
// Yifan Cao 1,* , Hao Liu 2,* Heng Zhang Chao Lin 2 Ruochen Li 1 Songyang Wu He Hongyong Weijuan 3 and Jiejie Xu Department of Biochemistry Molecular Biology, School Basic Medical Sciences, Fudan University, Shanghai, China General Surgery, Zhongshan Hospital, Immunology, * These authors contributed equally to this work Correspondence to: He, email: Zhang, Xu, Keywords : CXCR1, gastric cancer, nomogram, overall survival, adjuvant chemotherapy Received July 26, 2016 Accepted October 14,...
Background . Few studies have evaluated depression in female caregivers of patients with silicosis. Thus, the aim this study was to estimate prevalence such and clarify factors associated symptoms depression. Methods Depressive were assessed using Center for Epidemiologic Studies Depression Scale (CES-D). Results A total 561 participants met inclusion criteria enrolled study. The mean CES-D score 16.68, a standard deviation (SD) 8.57; sex-classified analysis indicated that 17.79 (SD: 10.17),...