A5059601857- Health Literacy and Information Accessibility
- Erythrocyte Function and Pathophysiology
- Phagocytosis and Immune Regulation
- Social Media in Health Education
- Testicular diseases and treatments
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Sperm and Testicular Function
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Sexual Differentiation and Disorders
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Cardiovascular Health and Risk Factors
- Orthopedic Surgery and Rehabilitation
- Nutrition, Health and Food Behavior
- Health disparities and outcomes
- Medical Malpractice and Liability Issues
- Patient-Provider Communication in Healthcare
- Ubiquitin and proteasome pathways
- Cardiovascular Disease and Adiposity
- Cancer-related Molecular Pathways
Kaiser Permanente
2021-2024
Stanford University
2016-2020
Waseda University
2019
Tohoku University
2019
Kagawa University
2019
Ehime University
2018-2019
PURPOSE To evaluate the safety, pharmacokinetics, and pharmacodynamics of Hu5F9-G4 (5F9), a humanized IgG4 antibody that targets CD47 to enable phagocytosis. PATIENTS AND METHODS Adult patients with solid tumors were treated in four cohorts: part A, determine priming dose; B, weekly maintenance C, study loading dose week 2; tumor biopsy cohort. RESULTS Sixty-two treated: 11 14 22 15 Part A used doses ranged from 0.1 3 mg/kg. On basis tolerability receptor occupancy studies showed 100%...
3019 Background: Hu5F9-G4 is a humanized monoclonal antibody that binds to CD47 and blocks its anti-phagocytic "don't-eat-me" signal, leading tumor phagocytosis cross-presentation T cells. highly expressed on red blood cells (RBCs) many human cancers, less normal tissues. Inhibition of CD47-SIRPα signaling by has broad antitumor activity in xenografts. In primate toxicology, caused transient anemia was mitigated single low Priming Dose enabling subsequent higher Maintenance Doses. Methods:...
Background Low socioeconomic status (SES) has been associated with a higher risk of aggressive breast cancer (BC) subtypes, but few studies have examined the independent effects both neighborhood‐level (nSES) and individual‐level SES measures. Methods This study included 5547 women from Pathways Life After Cancer Epidemiology cohorts who were diagnosed invasive BC. Generalized estimating equation models used to examine associations nSES (a composite score based on income, poverty, education,...
Abstract Background: Associations of nativity and breast cancer (BC) mortality are mixed in studies using registry data. We examined associations diverse women with detailed individual-level data on BC treatment subtype. Methods: The study population included 5,718 Asian (n=722, 71% foreign-born), Hispanic (n=631, 42% non-Hispanic White (n=4,365, 9% foreign-born) from the ENCLAVE Study diagnosed invasive 1996-2013 pooled, harmonized two (of three) cohorts Data nativity, reproductive...
421 Background: Social support is important to the management of breast cancer treatment. Our team has developed data from electronic health record (EHR) into structured ‘concept groups’ that will form basis for development EHRsupport, a computable, EHR-based measure social support. We report evaluation these concept groups against chart review as part our validation. Methods: built natural language processing (NLP) algorithm on clinical notes in 7,989 women diagnosed January 2006 September...
Abstract Breast cancer subtypes have been classified based on the gene expression profiles, and specifically effective treatments for each subtype developed applied in clinical situations. However, there is no treatment metaplastic breast carcinomas, which are pathological tissue types with poor prognosis. Metaplastic carcinomas almost resistant to existing chemotherapy because it has not identified specific therapeutic target molecules. Recently, Lehmann et al. reported that cancers...
Abstract Overexpression of HER2 in breast cancer is correlated with poor prognosis. HER2-targeted drugs, such as trastuzumab and lapatinib, have been successful to treat HER2-positive cancers, however, the acquisition drug resistance cells recognized. Here we suggest novel molecular targets cure cancers. The oncogenic roles Rac1, a Rho family small GTPase, variety cancers demonstrated. For example, elevated expression or hyperactivation Rac1 frequently observed human correlating their...
Abstract Background: Hispanic men in the U.S. experience second-highest incidence rate of testicular cancer, behind non-Hispanic (NH) White men. Incidence cancer is increasing U.S., despite reports a plateau during 1990’s, and increases are especially steep population. To date, literature does not address whether or observed differ according to neighborhood factors. Purpose: We examined rates changes over time for histologic subtypes (i.e., seminoma nonseminoma) socioeconomic status (nSES)...
Abstract Background: Black women are less likely to be married and report greater support from extended relatives than White in the general population. However, little information exists about women's personal networks how differences may influence treatment management after a diagnosis of breast cancer. Methods: We included two studies—study 1: 191 INSIGHT-BC study who were diagnosed with stages I-IV invasive cancer 2017-2021; 2: 24 I-III 2017-2020 received adjuvant chemotherapy recruited...