A5005427336- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Sulfur Compounds in Biology
- Phytoestrogen effects and research
- Nanoparticle-Based Drug Delivery
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Photodynamic Therapy Research Studies
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traditional Chinese Medicine Analysis
- Gout, Hyperuricemia, Uric Acid
- Natural Products and Biological Research
- Data Stream Mining Techniques
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plants and Neuroprotection
The First People’s Hospital of Lianyungang
2015-2024
Xuzhou Medical College
2018-2024
Lishui Central Hospital
2013-2023
Nanjing Medical University
2023
Lianyungang Oriental Hospital
2023
Children's Hospital of Zhejiang University
2020-2022
China Pharmaceutical University
2019-2022
Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes, and many which are likely to have functional roles vascular remodeling. However, their functions pulmonary arterial hypertension (PAH) remain largely unknown. Pulmonary remodeling is an important pathological feature PAH, leading increased resistance reduced compliance. artery smooth muscle cells (PASMCs) dysfunction involved Long noncoding potential regulators PASMCs...
Long noncoding RNAs (lncRNAs) have been discovered to be playing important role in various biological processes. However, the contribution of lncRNAs pulmonary artery hypertension (PAH) remains largely unknown. Pulmonary vascular remodeling is an pathological feature PAH, leading increased resistance and reduced compliance. Here, we investigated PAH. Differences mRNAs between hypoxia PAH rats normoxia were screened using microarray analysis. The results showed that 36 519 upregulated...
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that characterized by demyelination, axonal injury and neurological deterioration. Few medications are available for progressive MS, which associated with neuroinflammation confined to CNS compartment. Transient receptor potential melastatin 2 (TRPM2) calcium-permeable, non-selective cation channel plays pathological roles in wide range neuroinflammatory diseases; however, underlying molecular mechanisms TRPM2 remain...
Long non-coding RNA (lncRNA) plays important roles in many diseases, including pulmonary hypertension. The anti-diabetic drug metformin has been discovered to have protective effect on experimental artery hypertension (PAH). However, the exact mechanism of expression lncRNA PAH remains unclear. Here, we applied microarray analysis examine and mRNA proflies arteries (PAs) tissues rats with or without treatment. A total 24 lncRNAs (14 upregulated 10 down-regulated) 82 mRNAs (17 65 were...
Previous studies have shown that metformin (MET) prevents experimental pulmonary arterial hypertension (PAH) and activation of autophagy is involved in the development vascular remodeling. However, mechanism how MET inhibits reverses remodeling still unclear. The objective present study was to investigate role MET-induced hypoxia PAH protection underlying mechanisms. To examine effects on hypoxia, we treated rats with (100 mg/kg/day) after 3 weeks hypoxia. Hemodynamic changes, weight right...
Atherosclerosis (AS) is a systemic disease associated with lipid metabolic disorders and abnormal proliferation of smooth muscle cells. Baicalin flavonoid compound isolated from the dry roots Scutellaria baicalensis Georgi exerts anti‑proliferative effects in various types However, effect baicalin on AS remains unclear. In present study, serum samples were collected patients an vitro model was established using oxidized low‑density lipoprotein (ox‑LDL)‑treated human aorta vascular cells...
Isoflavonoids are putatively active components of Pueraria lobata and has been demonstrated prominent neuro-protection effect against cerebrovascular disorders, hypertension or Parkinson's disease (PD). However, the molecular basis for beneficial on nervous systems not well revealed. The present study aims to assess striatum exposure main isoflavonoids changes striatal extracellular neurotransmitters levels in rat brain after intravenous administration extracts (PLF), further elucidate its'...
Pulmonary artery hypertension (PAH) is a complex and progressive disease characterized by pulmonary vascular remodeling. Our previous study confirmed that NONRATT015587.2 could promote the proliferation of PASMCs However, exact mechanism which promotes PASMC unclear. Bioinformatics analysis revealed p21 located at downstream target NONRATT015587.2. expression localization were analyzed PCR fluorescence <em>in situ</em> hybridization. Proliferation was detected Cell Counting Kit‑8, flow...
Methylophiopogonanone A (MOA) is a naturally occurring homoisoflavonoid from the Chinese herb Ophiopogon japonicus, which has been demonstrated to attenuate myocardial apoptosis. However, metabolism of MOA remains unknown. The goal present work was investigate in vitro using liver microsomes and hepatocytes.The metabolites were generated by incubating with rat, monkey human or hepatocytes. resulting samples analyzed quadrupole-orbitrap high-resolution mass spectrometer. identified through...
Triptolide is a major active constituent isolated from Tripterygiumwilfordii Hook F, Chinese herbal medicine. This study investigated the intermolecular interaction between triptolide and bovine serum albumin (BSA).The fluorescence, circular dichroism (CD) molecular docking methods were used to investigate BSA. The binding constant, number of sites, subdomain thermodynamic parameters measured.The results this experiment revealed that intrinsic fluorescence BSA was effectively quenched by via...
Zinc oxide (ZnO) nanoparticles, due to their well-defined physico-chemical and antimicrobial attributes have been presented lately as favourable theranostic nanoplatforms for drug delivery. We hypothesized that surface modification of ZnO nanoparticle with activated polyethylene glycol folic acid might be great importance in targeted delivery nasopharyngeal carcinoma since cells possess folate receptors absent normal cells. Therefore this study, we prepared characterized PEG conjugated dual...
Objective: To summarize the situation of antineoplastic agents-induced interstitial lung diseases (ILD), provide reference for strengthening clinical management druginduced (DILD). Methods: We retrospectively investigated medical records 12 patients with ILD in a hospital between January and December 2020. Data collected included patients’ characteristic (gender, age, ECOG PS score, smoking history, primary tumor, concurrent or complications.) treatment conditions (DILD-causing drugs,...
To evaluate the efficacy, safety, and economics of mecapegfilgrastim recombinant human granulocyte colony-stimulating factor (rhG-CSF) in primary prevention chemotherapy-related neutropenia non-small cell lung cancer (NSCLC).